doxazosin has been researched along with Albuminuria in 16 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The CARDHIAC (CARduran en pacientes Diabéticos con HIpertensi'on Arterial no Controlada) trial examined the effects of doxazosin gastrointestinal therapeutic system (GITS) and atenolol on 3 separate measures of target-organ damage--left ventricular mass index (LVMI), carotid intima media thickness (IMT), and urinary albumin excretion (UAE)--in patients with type 2 diabetes mellitus and hypertension." | 9.13 | Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: a 9-month, prospective, randomized, open-label, blinded-evaluation trial. ( Barrios, V; Calderon, A; Echarri, R; Escobar, C; Tomás, JP, 2008) |
| "Aim of the study was to evaluate the effects of a 6 month treatment with doxazosin on blood pressure profile, left ventricular morphology and function and microalbuminuria in non diabetics patients with mild to moderate essential hypertension." | 9.08 | [Renal and cardiac effects of chronic doxazosin therapy in patients with essential arterial hypertension]. ( Bignotti, M; Lamponi, M, 1996) |
| "Doxazosin was taken orally once at bedtime for 1 to 3 months." | 6.71 | The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements. ( Ikarashi, T; Kamoi, K, 2005) |
| "Hydrochlorothiazide was then added for the subsequent 4 months." | 6.69 | Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study. ( Half-Onn, E; Levi, Z; Rachmani, R; Ravid, M; Slavachevsky, I, 1998) |
| "Doxazosin was generally well-tolerated; four patients (29%) reported mild-to-moderate treatment-related adverse events." | 6.69 | Hand vein responses to noradrenaline in normotensive patients with insulin-dependent diabetes mellitus and microalbuminuria: effects of alpha-adrenoceptor blockade with doxazosin. ( Bodmer, CW; Lake, D; Savage, MW; Williams, G, 1999) |
| "Both doxazosin treatment and good glycemic control normalized these abnormalities in diabetic rats." | 5.29 | Doxazosin prevents proteinuria and glomerular loss of heparan sulfate in diabetic rats. ( Alluru, I; Jyothirmayi, GN; Reddi, AS, 1996) |
| "The CARDHIAC (CARduran en pacientes Diabéticos con HIpertensi'on Arterial no Controlada) trial examined the effects of doxazosin gastrointestinal therapeutic system (GITS) and atenolol on 3 separate measures of target-organ damage--left ventricular mass index (LVMI), carotid intima media thickness (IMT), and urinary albumin excretion (UAE)--in patients with type 2 diabetes mellitus and hypertension." | 5.13 | Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: a 9-month, prospective, randomized, open-label, blinded-evaluation trial. ( Barrios, V; Calderon, A; Echarri, R; Escobar, C; Tomás, JP, 2008) |
| "Enalapril, but not doxazosin, reduces albuminuria in insulin dependent diabetes mellitus patients with nephropathy." | 5.08 | Contrasting effects of angiotensin converting inhibitor and alpha-1-antagonist on albuminuria in insulin-dependent diabetes mellitus patients with nephropathy. ( Berg, KJ; Blystad, L; Fauchald, P; Hartmann, A; Holdaas, H; Langberg, H, 1995) |
| "Aim of the study was to evaluate the effects of a 6 month treatment with doxazosin on blood pressure profile, left ventricular morphology and function and microalbuminuria in non diabetics patients with mild to moderate essential hypertension." | 5.08 | [Renal and cardiac effects of chronic doxazosin therapy in patients with essential arterial hypertension]. ( Bignotti, M; Lamponi, M, 1996) |
| "The effect of doxazosin versus captopril on blood pressure, albuminuria, and left ventricular mass was studied in 33 hypertensive type-1 diabetic patients randomized to 6 months treatment with captopril (17 patients, mean daily dose 100 mg) or doxazosin (16 patients, mean daily dose 9 mg)." | 5.08 | Factors influencing reduction in blood pressure and left ventricular mass in hypertensive type-1 diabetic patients using captopril or doxazosin for 6 months. ( Aanderud, S; Gerdts, E; Lund-Johansen, P; Myking, OL; Omvik, P; Svarstad, E, 1998) |
| " We assessed the effects of doxazosin on 24-h BP and spectral analysis of heart rate variability in hypertensive Type 2 diabetic patients with macroalbuminuria and compared the results with those in hypertensive Type 2 diabetic patients with normoalbuminuria and non-diabetic patients with essential hypertension." | 3.73 | Effects of doxazosin on ambulatory blood pressure and sympathetic nervous activity in hypertensive Type 2 diabetic patients with overt nephropathy. ( Hasegawa, K; Kuji, T; Ogawa, N; Shimura, G; Tochikubo, O; Umemura, S; Yasuda, G, 2005) |
| "Doxazosin was taken orally once at bedtime for 1 to 3 months." | 2.71 | The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements. ( Ikarashi, T; Kamoi, K, 2005) |
| "Hydrochlorothiazide was then added for the subsequent 4 months." | 2.69 | Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study. ( Half-Onn, E; Levi, Z; Rachmani, R; Ravid, M; Slavachevsky, I, 1998) |
| "Doxazosin was generally well-tolerated; four patients (29%) reported mild-to-moderate treatment-related adverse events." | 2.69 | Hand vein responses to noradrenaline in normotensive patients with insulin-dependent diabetes mellitus and microalbuminuria: effects of alpha-adrenoceptor blockade with doxazosin. ( Bodmer, CW; Lake, D; Savage, MW; Williams, G, 1999) |
| "To assess the renal benefits of combined angiotensin-converting enzyme inhibition and alpha(1)-adrenergic antagonism, we studied the antihypertensive and renoprotective effects of temocapril (TMP) alone and in combination with doxazosin (DOX) in spontaneously hypertensive rats (SHR)/Izumo rats with renal ablation." | 1.32 | Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation. ( Abe, K; Ito, O; Kanazawa, M; Kohzuki, M; Kurosawa, H; Minami, N; Saito, T; Yasujima, M, 2004) |
| "Both doxazosin treatment and good glycemic control normalized these abnormalities in diabetic rats." | 1.29 | Doxazosin prevents proteinuria and glomerular loss of heparan sulfate in diabetic rats. ( Alluru, I; Jyothirmayi, GN; Reddi, AS, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoshide, S | 4 |
| Matsui, Y | 4 |
| Shibasaki, S | 4 |
| Eguchi, K | 4 |
| Ishikawa, J | 4 |
| Ishikawa, S | 3 |
| Kabutoya, T | 3 |
| Schwartz, JE | 2 |
| Pickering, TG | 3 |
| Shimada, K | 4 |
| Kario, K | 5 |
| Kanazawa, M | 1 |
| Kohzuki, M | 1 |
| Kurosawa, H | 1 |
| Minami, N | 1 |
| Ito, O | 1 |
| Saito, T | 1 |
| Yasujima, M | 1 |
| Abe, K | 1 |
| Kamoi, K | 1 |
| Ikarashi, T | 1 |
| Yasuda, G | 1 |
| Hasegawa, K | 1 |
| Kuji, T | 1 |
| Ogawa, N | 1 |
| Shimura, G | 1 |
| Umemura, S | 1 |
| Tochikubo, O | 1 |
| Barrios, V | 1 |
| Escobar, C | 1 |
| Tomás, JP | 1 |
| Calderon, A | 1 |
| Echarri, R | 1 |
| Holdaas, H | 1 |
| Hartmann, A | 1 |
| Berg, KJ | 1 |
| Langberg, H | 1 |
| Blystad, L | 1 |
| Fauchald, P | 1 |
| Jyothirmayi, GN | 1 |
| Alluru, I | 1 |
| Reddi, AS | 2 |
| Bignotti, M | 1 |
| Lamponi, M | 1 |
| Rachmani, R | 1 |
| Levi, Z | 1 |
| Slavachevsky, I | 1 |
| Half-Onn, E | 1 |
| Ravid, M | 1 |
| Gerdts, E | 1 |
| Svarstad, E | 1 |
| Aanderud, S | 1 |
| Myking, OL | 1 |
| Lund-Johansen, P | 1 |
| Omvik, P | 1 |
| Bodmer, CW | 1 |
| Lake, D | 1 |
| Savage, MW | 1 |
| Williams, G | 1 |
| Nimmagadda, VR | 1 |
| Lefkowitz, A | 1 |
| Kuo, HR | 1 |
| Bollineni, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Doxazosin on Ambulatory Blood Pressure and Sympathetic Nervous Activity in Hypertensive Patients With Diabetic Nephropathy[NCT00295555] | Phase 4 | 98 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for doxazosin and Albuminuria
| Article | Year |
|---|---|
Orthostatic hypertension detected by self-measured home blood pressure monitoring: a new cardiovascular risk factor for elderly hypertensives.
Topics: Aged; Aged, 80 and over; Aging; Albuminuria; Antihypertensive Agents; Autonomic Nervous System Disea | 2008 |
[Series, clinical study from Japan and its reflections; Japan Morning Surge-1 (JMS-1) study].
Topics: Adrenergic alpha-1 Receptor Antagonists; Albuminuria; Doxazosin; Humans; Hypertension; Natriuretic P | 2011 |
The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements.
Topics: Adrenergic alpha-Antagonists; Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Blood Pres | 2005 |
Comparison of the effects of doxazosin and atenolol on target organ damage in adults with type 2 diabetes mellitus and hypertension in the CARDHIAC study: a 9-month, prospective, randomized, open-label, blinded-evaluation trial.
Topics: Age Factors; Albuminuria; Antihypertensive Agents; Atenolol; Carotid Artery, Common; Carotid Artery, | 2008 |
An alpha-adrenergic blocker titrated by self-measured blood pressure recordings lowered blood pressure and microalbuminuria in patients with morning hypertension: the Japan Morning Surge-1 Study.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Albuminuria; Blood Pressure; Blood Pressure D | 2008 |
Contrasting effects of angiotensin converting inhibitor and alpha-1-antagonist on albuminuria in insulin-dependent diabetes mellitus patients with nephropathy.
Topics: Adult; Albuminuria; Creatinine; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Doxazosin; Enalap | 1995 |
[Renal and cardiac effects of chronic doxazosin therapy in patients with essential arterial hypertension].
Topics: Albuminuria; Antihypertensive Agents; Doxazosin; Echocardiography; Female; Heart; Humans; Hypertensi | 1996 |
Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; An | 1998 |
Factors influencing reduction in blood pressure and left ventricular mass in hypertensive type-1 diabetic patients using captopril or doxazosin for 6 months.
Topics: Adult; Albuminuria; Antihypertensive Agents; Blood Pressure; Captopril; Diabetes Mellitus, Type 1; D | 1998 |
Hand vein responses to noradrenaline in normotensive patients with insulin-dependent diabetes mellitus and microalbuminuria: effects of alpha-adrenoceptor blockade with doxazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Albuminuria; Analysis of Variance; Consumer Product Safety; Dia | 1999 |
6 other studies available for doxazosin and Albuminuria
| Article | Year |
|---|---|
Impact of arterial stiffness reduction on urinary albumin excretion during antihypertensive treatment: the Japan morning Surge-1 study.
Topics: Aged; Albuminuria; Ankle Brachial Index; Antihypertensive Agents; Atenolol; Blood Flow Velocity; Bra | 2010 |
Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Albuminuria; Angiotensin-Conv | 2004 |
Effects of doxazosin on ambulatory blood pressure and sympathetic nervous activity in hypertensive Type 2 diabetic patients with overt nephropathy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Albuminuria; Blood Pressure; Blood Pre | 2005 |
The Japan Morning Surge-1 (JMS-1) study: protocol description.
Topics: Albuminuria; Antihypertensive Agents; Blood Pressure Determination; Circadian Rhythm; Clinical Proto | 2006 |
Doxazosin prevents proteinuria and glomerular loss of heparan sulfate in diabetic rats.
Topics: Adrenergic alpha-Antagonists; Albuminuria; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus | 1996 |
Effect of antihypertensive therapy on renal injury in type 2 diabetic rats with hypertension.
Topics: Albuminuria; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diabetes Mellitus, Typ | 2000 |