doxazosin has been researched along with Aging in 9 studies
Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
doxazosin : A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study the effects of a single daily dose of doxazosin (an alpha-adrenergic blocker) given at night were evaluated in 112 patients with mild hypertension." | 9.07 | Differential effects of doxazosin on clinic and ambulatory pressure according to age, gender, and presence of white coat hypertension. Results of the HALT Study. Hypertension and Lipid Trial Study Group. ( Levenstein, M; Pickering, TG; Walmsley, P, 1994) |
| "We conducted ambulatory BP monitoring three times (twice at baseline and after nighttime dosing of the alpha1-blocker doxazosin) in 98 elderly hypertensive patients in whom the presence of silent cerebral infarcts (SCI) was assessed by brain magnetic resonance imaging." | 5.11 | Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system. ( Eguchi, K; Hoshide, S; Hoshide, Y; Ishikawa, J; Kario, K; Morinari, M; Pickering, TG; Shimada, K, 2004) |
| "In this study the effects of a single daily dose of doxazosin (an alpha-adrenergic blocker) given at night were evaluated in 112 patients with mild hypertension." | 5.07 | Differential effects of doxazosin on clinic and ambulatory pressure according to age, gender, and presence of white coat hypertension. Results of the HALT Study. Hypertension and Lipid Trial Study Group. ( Levenstein, M; Pickering, TG; Walmsley, P, 1994) |
| " This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR." | 3.70 | Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats. ( Cachofeiro, V; Lahera, V; Maeso, R; Navarro-Cid, J; Rodrigo, E; Ruilope, LM, 1999) |
| "Doxazosin GITS was well tolerated in the subjects studied, including young and elderly males and females." | 2.69 | Clinical pharmacokinetics of doxazosin in a controlled-release gastrointestinal therapeutic system (GITS) formulation. ( Chung, M; Meredith, P; Puente, J; Sweeney, M; Vashi, V, 1999) |
| " In young subjects the mean bioavailability was 65% and the mean terminal elimination half-lives were 9." | 1.27 | Clinical pharmacological studies with doxazosin. ( Elliott, HL; Meredith, PA; Reid, JL; Vincent, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Proshchaev, KI | 1 |
| Slivkin, VV | 1 |
| Filippov, SV | 1 |
| Il'nitskiĭ, AN | 1 |
| Gileva, VV | 1 |
| Liutsko, VV | 1 |
| Hoshide, S | 2 |
| Matsui, Y | 1 |
| Shibasaki, S | 1 |
| Eguchi, K | 2 |
| Ishikawa, J | 2 |
| Ishikawa, S | 1 |
| Kabutoya, T | 1 |
| Schwartz, JE | 1 |
| Pickering, TG | 3 |
| Shimada, K | 2 |
| Kario, K | 2 |
| Morinari, M | 1 |
| Hoshide, Y | 1 |
| McLeod, SD | 1 |
| Cairncross, KD | 1 |
| Levenstein, M | 1 |
| Walmsley, P | 1 |
| Chung, M | 1 |
| Vashi, V | 1 |
| Puente, J | 1 |
| Sweeney, M | 1 |
| Meredith, P | 1 |
| Maeso, R | 1 |
| Navarro-Cid, J | 1 |
| Rodrigo, E | 1 |
| Ruilope, LM | 1 |
| Lahera, V | 1 |
| Cachofeiro, V | 1 |
| Charuel, C | 1 |
| Comby, P | 1 |
| Monro, AM | 1 |
| Elliott, HL | 1 |
| Meredith, PA | 1 |
| Vincent, J | 1 |
| Reid, JL | 1 |
4 trials available for doxazosin and Aging
| Article | Year |
|---|---|
Orthostatic hypertension detected by self-measured home blood pressure monitoring: a new cardiovascular risk factor for elderly hypertensives.
Topics: Aged; Aged, 80 and over; Aging; Albuminuria; Antihypertensive Agents; Autonomic Nervous System Disea | 2008 |
Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system.
Topics: Adrenergic alpha-Antagonists; Aged; Aging; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Br | 2004 |
Differential effects of doxazosin on clinic and ambulatory pressure according to age, gender, and presence of white coat hypertension. Results of the HALT Study. Hypertension and Lipid Trial Study Group.
Topics: Adult; Aged; Aging; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Data Interpretation, Stat | 1994 |
Clinical pharmacokinetics of doxazosin in a controlled-release gastrointestinal therapeutic system (GITS) formulation.
Topics: Adult; Aging; Antihypertensive Agents; Area Under Curve; Biological Availability; Cross-Over Studies | 1999 |
5 other studies available for doxazosin and Aging
| Article | Year |
|---|---|
[Clinical and neuroimmunoendocrine effects of doxasosine in treatment of benign hyperplasia of the prostate in elderly people].
Topics: Adrenergic alpha-Antagonists; Aged; Aging; Cell Adhesion Molecules; Doxazosin; Humans; Interleukin-6 | 2008 |
Preliminary evidence of a synergistic alpha 1- and beta 1-adrenoceptor regulation of rat pineal hydroxyindole-O-methyltransferase.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Body Weight; Circadian Rhythm; Doxazosin; Fencl | 1995 |
Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aging; Angiotensin II; Animals; Antihypertensive Agents | 1999 |
Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half-life: interplay of age and diurnal feeding pattern.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Do | 1992 |
Clinical pharmacological studies with doxazosin.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aging; Antihypertensive Agents; Blood Pressure; Doxazosin | 1986 |