doxapram has been researched along with Seizures in 4 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We induced generalized seizures by cortical injection of penicillin in anesthetized, paralyzed cats." | 5.28 | Role of endogenous adenosine in recurrent generalized seizures. ( Dowell, RT; Eldridge, FL; Paydarfar, D; Scott, SC, 1989) |
| " Mice pretreated with procaine, lidocaine, and tetracaine had a lower incidence of seizures when convulsive doses of either nikethamide or doxapram hydrochloride were given intraperitoneally." | 3.65 | Interaction between local anesthetics and analeptic drugs. ( Aldrete, JA; Thompson, RG, 1975) |
| "We induced generalized seizures by cortical injection of penicillin in anesthetized, paralyzed cats." | 1.28 | Role of endogenous adenosine in recurrent generalized seizures. ( Dowell, RT; Eldridge, FL; Paydarfar, D; Scott, SC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albertson, TE | 1 |
| Stark, LG | 1 |
| Joy, RM | 1 |
| Thompson, RG | 1 |
| Aldrete, JA | 1 |
| Eldridge, FL | 1 |
| Paydarfar, D | 1 |
| Scott, SC | 1 |
| Dowell, RT | 1 |
| Kuga, T | 1 |
| Naito, J | 1 |
4 other studies available for doxapram and Seizures
| Article | Year |
|---|---|
The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats.
Topics: Amygdala; Animals; Diazepam; Doxapram; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital | 1983 |
Interaction between local anesthetics and analeptic drugs.
Topics: Anesthetics, Local; Animals; Central Nervous System Stimulants; Doxapram; Drug Interactions; Lidocai | 1975 |
Role of endogenous adenosine in recurrent generalized seizures.
Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Cats; Cerebral Cortex; Dipyridamole; Doxapram; Nalo | 1989 |
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrolinone hydrochloride (doxapram). 1. The action on the central nervous system].
Topics: Amides; Animals; Atropine; Blood Pressure; Central Nervous System; Central Nervous System Stimulants | 1973 |