doxapram has been researched along with Respiratory Insufficiency in 72 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 9.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 5.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "Four cases are reported where patients reacted with severe restlessness, violence or hallucinations at low doses of doxapram infusion." | 3.65 | Side effects of doxapram infusion. ( Baxter, AD, 1976) |
| "GAL021 is a calcium-activated potassium (BKCa) channel blocker that causes reversal of opioid-induced respiratory depression in animals due to a stimulatory effect on ventilation at the carotid bodies." | 2.79 | Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers. ( Dahan, A; Hay, J; McLeod, JF; Okkerse, P; Roozekrans, M; van der Schrier, R, 2014) |
| "Doxapram reversed the respiratory depression but did not alter analgesia." | 2.65 | Antagonists of morphine-induced respiratory depression. A study in postoperative patients. ( Gairola, RL; Gupta, PK; Pandley, K, 1980) |
| "Acute-on-chronic respiratory failure is becoming an increasingly common medical emergency, mostly as a result of exacerbations of chronic obstructive pulmonary disease." | 2.44 | Managing acute on chronic respiratory failure: a guide to non-invasive ventilation. ( Goldring, JJ; Wedzicha, JA, 2008) |
| "Doxapram is a respiratory stimulant used to stimulate respiration in this setting." | 2.42 | Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease. ( Greenstone, M; Lasserson, TJ, 2003) |
| "Doxapram is a respiratory stimulant used to stimulate breathing in this setting." | 2.41 | Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease. ( Greenstone, M, 2000) |
| "Doxapram was an equipotent inhibitor of human TASK-1 and TASK-3 channels, compared with mouse channel variants, where it was more selective for TASK-1 and heterodimers of TASK-1 and TASK-3." | 1.56 | Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels. ( Cunningham, KP; MacIntyre, DE; Mathie, A; Veale, EL, 2020) |
| "Morphine (3." | 1.43 | Reversal of morphine-induced respiratory depression by doxapram in anesthetized rats. ( Haji, A; Kimura, S; Ohi, Y, 2016) |
| "To determine whether CX1942 reverses respiratory depression in etorphine-immobilized goats, and to compare its effects with those of doxapram hydrochloride." | 1.43 | Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats (Capra hircus). ( Fuller, A; Greer, JJ; Haw, AJ; Meyer, LC, 2016) |
| "Etorphine immobilization caused respiratory depression and hypoxia (mean+/-SD, PaCO(2)=51+/-2 mmHg, PaO(2)=40+/-3 mmHg)." | 1.36 | Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). ( Fick, LG; Fuller, A; Hetem, RS; Meyer, LC; Mitchell, D, 2010) |
| " The mechanism of action, indications, dosing methods, and potential side effects of this agent are discussed." | 1.29 | Doxapram reversal of respiratory failure in a patient refusing assisted ventilation. ( Euerle, BD; McNamara, RM, 1994) |
| "A 51-year-old woman with chronic respiratory failure (status after tuberculosis) was given an infusion of doxapram hydrochloride (1 to 2 mg/kg of body weight per hour) for four episodes of acute exacerbation of her condition." | 1.26 | Doxapram hydrochloride in the treatment of acute exacerbation of chronic respiratory failure. A patient with four episodes treated without use of a respirator. ( Heki, S; Kato, M; Nakashima, M; Ohi, M; Sagawa, Y, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (76.39) | 18.7374 |
| 1990's | 7 (9.72) | 18.2507 |
| 2000's | 3 (4.17) | 29.6817 |
| 2010's | 6 (8.33) | 24.3611 |
| 2020's | 1 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Cunningham, KP | 1 |
| MacIntyre, DE | 1 |
| Mathie, A | 1 |
| Veale, EL | 1 |
| Algera, MH | 1 |
| Kamp, J | 1 |
| van der Schrier, R | 3 |
| van Velzen, M | 1 |
| Niesters, M | 1 |
| Aarts, L | 1 |
| Dahan, A | 3 |
| Olofsen, E | 2 |
| Roozekrans, M | 2 |
| Okkerse, P | 1 |
| Hay, J | 1 |
| McLeod, JF | 1 |
| Haji, A | 1 |
| Kimura, S | 1 |
| Ohi, Y | 1 |
| Haw, AJ | 1 |
| Meyer, LC | 2 |
| Greer, JJ | 1 |
| Fuller, A | 2 |
| Boom, M | 1 |
| Mooren, R | 1 |
| Goldring, JJ | 1 |
| Wedzicha, JA | 2 |
| Hetem, RS | 1 |
| Fick, LG | 1 |
| Mitchell, D | 1 |
| Greenstone, M | 2 |
| Lasserson, TJ | 1 |
| FRAIMOW, W | 1 |
| DIAMOND, P | 1 |
| CATHCART, RT | 1 |
| Namba, H | 1 |
| Akimoto, M | 1 |
| Yamaura, A | 1 |
| Hagihara, Y | 1 |
| Makino, H | 1 |
| Sakurai, K | 1 |
| Lake, AP | 1 |
| Houston, T | 1 |
| Hunter, AR | 1 |
| Crawford, ME | 1 |
| Carl, P | 2 |
| Ravlo, O | 2 |
| Fukushima, Y | 1 |
| Klausen, NO | 2 |
| Agner, E | 1 |
| Tougaard, L | 1 |
| Sørensen, B | 1 |
| Gairola, RL | 1 |
| Gupta, PK | 2 |
| Pandley, K | 1 |
| Kishi, F | 1 |
| Murao, M | 1 |
| Kwik, RS | 1 |
| McNamara, RM | 1 |
| Euerle, BD | 1 |
| Bott, J | 1 |
| Carroll, MP | 1 |
| Conway, JH | 1 |
| Keilty, SE | 1 |
| Ward, EM | 1 |
| Brown, AM | 1 |
| Paul, EA | 1 |
| Elliott, MW | 1 |
| Godfrey, RC | 1 |
| Moxham, J | 1 |
| Angus, RM | 1 |
| Ahmed, AA | 1 |
| Fenwick, LJ | 1 |
| Peacock, AJ | 1 |
| Ohi, M | 3 |
| Nakashima, M | 2 |
| Heki, S | 2 |
| Kato, M | 2 |
| Sagawa, Y | 2 |
| de Castro, J | 1 |
| Andrieu, S | 1 |
| Clerckx, A | 1 |
| Marcq, M | 1 |
| Gepts, L | 1 |
| Erven, W | 1 |
| Minette, A | 1 |
| Gay, R | 1 |
| Flenley, DC | 2 |
| Orwin, JM | 1 |
| Houser, WC | 1 |
| Schlueter, DP | 2 |
| Hamamoto, Y | 1 |
| Tateishi, S | 1 |
| Orita, Y | 1 |
| Fujita, M | 1 |
| Asai, N | 1 |
| Tourreau, A | 1 |
| Jeanneret, A | 1 |
| Aiache, JM | 1 |
| Roche, G | 1 |
| Roche, E | 1 |
| Molina, C | 1 |
| Baxter, AD | 1 |
| Riordan, JF | 2 |
| Sillett, RW | 2 |
| McNicol, MW | 2 |
| Conti, F | 1 |
| Bertoli, L | 1 |
| Mantero, O | 1 |
| Beesley, JR | 1 |
| Bowden, G | 1 |
| Hardy, RH | 1 |
| Reynolds, TD | 1 |
| Jeffrey, AA | 1 |
| Warren, PM | 1 |
| Westermann, CJ | 1 |
| Duurkens, VA | 1 |
| Lie-A Huen, L | 1 |
| Locke, RG | 1 |
| Salvia, JV | 1 |
| Thangathurai, D | 1 |
| Nelson, D | 1 |
| Cheung, M | 1 |
| Fitzal, S | 1 |
| Andersen, JB | 1 |
| Jensen, NH | 1 |
| Qvist, J | 1 |
| Johansen, SH | 1 |
| Akiyama, Y | 1 |
| Kawakami, Y | 1 |
| Otsuka, H | 1 |
| Crawford, M | 1 |
| Bach, V | 1 |
| Romanic, BM | 1 |
| Lattin, NE | 1 |
| Sochocky, S | 1 |
| Winnie, AP | 1 |
| Collins, VJ | 1 |
| Pavan, WL | 1 |
| Vetrò, A | 1 |
| Petterino, E | 1 |
| Calogero, G | 1 |
| Respighi, E | 1 |
| Toso, A | 1 |
| Zocche, GP | 1 |
| Insinna, F | 1 |
| Warembourg, H | 1 |
| Peltier, JM | 1 |
| Vasseur, P | 1 |
| Ohresser, P | 2 |
| Leonardelli, M | 2 |
| Shepperd, JD | 1 |
| Sainty, JM | 1 |
| Alibert, R | 1 |
| Marukawa, S | 1 |
| Sugiyama, D | 1 |
| Segawa, S | 1 |
| Shibata, T | 1 |
| Hayashi, S | 1 |
| Okada, K | 1 |
| Nagai, H | 1 |
| Miyata, S | 1 |
| Maruo, T | 1 |
| Takeuchi, M | 1 |
| Moser, KM | 1 |
| Luchsinger, PC | 1 |
| Adamson, JS | 1 |
| McMahon, SM | 1 |
| Spivack, M | 1 |
| Weg, JG | 1 |
| Norman, JR | 1 |
| Proctor, CA | 1 |
| Conerly, AW | 1 |
| Labrousse, J | 1 |
| Farhad, B | 1 |
| Lissac, J | 1 |
| Fritts, HW | 1 |
| Rochester, DF | 1 |
| Plaut, MR | 1 |
| Gifford, RR | 1 |
| Jacobsen, PM | 1 |
| Moore, J | 1 |
| Rowed, DW | 1 |
| De la Torre, JC | 1 |
| Prendergast, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists - a Study in Opioid naïve Individuals and Chronic Opioid Users Under Real-life Conditions[NCT05338632] | Phase 1 | 24 participants (Anticipated) | Interventional | 2022-06-24 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for doxapram and Respiratory Insufficiency
| Article | Year |
|---|---|
Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal.
Topics: Analgesics, Opioid; Carotid Body; Doxapram; Drug Design; Humans; Models, Biological; Naloxone; Narco | 2019 |
Managing acute on chronic respiratory failure: a guide to non-invasive ventilation.
Topics: Acute Disease; Aged; Anti-Bacterial Agents; Chronic Disease; Cystic Fibrosis; Doxapram; Humans; Midd | 2008 |
Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease.
Topics: Acute Disease; Doxapram; Humans; Lung Diseases, Obstructive; Randomized Controlled Trials as Topic; | 2003 |
Doxapram for ventilatory failure due to exacerbations of chronic obstructive pulmonary disease.
Topics: Acute Disease; Doxapram; Humans; Lung Diseases, Obstructive; Respiratory Insufficiency; Respiratory | 2000 |
[The pharmacodynamics of respiratory stimulants (author's transl)].
Topics: Almitrine; Animals; Cardiovascular System; Central Nervous System; Central Nervous System Stimulants | 1979 |
[Treatment of acute hypercapnic respiratory insufficiency in chronic obstructive bronchopneumopathy. New trends in controlled oxygen therapy].
Topics: Adult; Aged; Aminophylline; Chronic Disease; Doxapram; Female; Humans; Hypercapnia; Lung Diseases, O | 1975 |
Pharmacologic manipulation of the respiratory control center in the infant.
Topics: Almitrine; Doxapram; Drug Therapy; Humans; Infant; Infant, Newborn; Naloxone; Progesterone; Prostagl | 1990 |
[Analeptics and anesthesia].
Topics: Anesthetics; Central Nervous System Stimulants; Doxapram; Humans; Respiratory Insufficiency | 1989 |
[Are respiratory stimulants necessary? No].
Topics: Almitrine; Central Nervous System Stimulants; Chemoreceptor Cells; Doxapram; Humans; Lung Diseases, | 1987 |
[Are respiratory stimulants necessary? Yes].
Topics: Almitrine; Central Nervous System Stimulants; Doxapram; Humans; Naloxone; Piperazines; Progesterone; | 1987 |
Cor pulmonale.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Bronchodilator Agents; Central Nervous System Stimul | 1974 |
12 trials available for doxapram and Respiratory Insufficiency
| Article | Year |
|---|---|
Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers.
Topics: Adolescent; Adult; Alfentanil; Analgesia; Analgesics, Opioid; Cross-Over Studies; Double-Blind Metho | 2014 |
Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Blood Pressure; Cardiac Output; Central Nervous S | 2017 |
Antagonists of morphine-induced respiratory depression. A study in postoperative patients.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Doxapram; Humans; Levallorphan; Middle Aged; M | 1980 |
Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Blood; Bronchodilator Agents; Carbon Dioxide; Doxapr | 1993 |
Comparison of the acute effects on gas exchange of nasal ventilation and doxapram in exacerbations of chronic obstructive pulmonary disease.
Topics: Doxapram; Female; Humans; Intermittent Positive-Pressure Ventilation; Lung Diseases, Obstructive; Ma | 1996 |
[Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results].
Topics: Aged; Almitrine; Carbon Dioxide; Central Nervous System Stimulants; Chronic Disease; Doxapram; Human | 1979 |
The effect of doxapram on buprenorphine induced respiratory depression.
Topics: Adult; Analgesics; Blood Pressure; Carbon Dioxide; Clinical Trials as Topic; Doxapram; Heart Rate; H | 1977 |
A controlled trail of doxapram in acute respiratory failure.
Topics: Acute Disease; Aged; Bronchitis; Carbon Dioxide; Catheterization; Chronic Disease; Clinical Trials a | 1975 |
[A pharmacologic respiratory stimulant, doxapram, used in acute deterioration in patients with chronic respiratory failure].
Topics: Aged; Clinical Trials as Topic; Doxapram; Humans; Middle Aged; Random Allocation; Respiratory Insuff | 1989 |
[Doxapram therapy in acute progressive chronic respiratory failure].
Topics: Clinical Trials as Topic; Doxapram; Drug Evaluation; Humans; Respiratory Insufficiency | 1989 |
A new stimulant for ventilatory failure?
Topics: Bronchitis; Carbon Dioxide; Clinical Trials as Topic; Doxapram; Humans; Oxygen; Oxygen Inhalation Th | 1973 |
Respiratory stimulation with intravenous doxapram in respiratory failure. A double-blind co-operative study.
Topics: Adult; Aged; Carbon Dioxide; Clinical Trials as Topic; Doxapram; Female; Follow-Up Studies; Humans; | 1973 |
49 other studies available for doxapram and Respiratory Insufficiency
| Article | Year |
|---|---|
Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels.
Topics: Cell Line; Doxapram; Humans; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium Channels, Tand | 2020 |
Reversal of morphine-induced respiratory depression by doxapram in anesthetized rats.
Topics: Anesthesia; Animals; Doxapram; Male; Morphine; Phrenic Nerve; Rats; Rats, Wistar; Respiratory Insuff | 2016 |
Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats (Capra hircus).
Topics: Analgesics, Opioid; Animals; Doxapram; Etorphine; Female; Goats; Hypoxia; Immobilization; Naltrexone | 2016 |
Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus).
Topics: Analgesics, Opioid; Animals; Animals, Wild; Antelopes; Carbon Dioxide; Doxapram; Etorphine; Hypoxia; | 2010 |
VENTILATORY RESPONSE OF PATIENTS WITH PULMONARY EMPHYSEMA TO DOXAPRAM HYDROCHLORIDE.
Topics: Aged; Blood Gas Analysis; Central Nervous System Stimulants; Doxapram; Drug Therapy; Humans; Pulmona | 1965 |
Effects of a respiratory stimulant on intracranial pressure and cerebral blood flow.
Topics: Animals; Cats; Cerebrovascular Circulation; Doxapram; Female; Intracranial Pressure; Male; Pseudotum | 1983 |
Effect of doxapram on heavy sedation produced by intravenous diazepam.
Topics: Diazepam; Doxapram; Humans; Respiratory Insufficiency | 1983 |
Doxapram and idiopathic hypoventilation.
Topics: Doxapram; Female; Humans; Middle Aged; Postoperative Complications; Respiratory Insufficiency | 1984 |
[A possible clinical application of doxapram (Dopram). A new respiratory stimulant].
Topics: Anesthesia, Inhalation; Animals; Doxapram; Hemodynamics; Humans; Postoperative Complications; Respir | 1984 |
[Respiratory failure: therapeutic trial on its acute exacerbation].
Topics: Acute Disease; Doxapram; Drug Therapy, Combination; Humans; Respiratory Insufficiency; Spironolacton | 1983 |
Pneumatosis cystoides coli in chronic respiratory failure.
Topics: Aged; Doxapram; Humans; Hyperbaric Oxygenation; Male; Pneumatosis Cystoides Intestinalis; Respiratio | 1982 |
[Respiratory stimulant (author's transl)].
Topics: Chronic Disease; Doxapram; Humans; Respiratory Insufficiency | 1981 |
Doxapram in respiratory failure. A case presentation.
Topics: Aged; Doxapram; Humans; Intensive Care Units; Male; Monitoring, Physiologic; Respiratory Insufficien | 1980 |
Doxapram reversal of respiratory failure in a patient refusing assisted ventilation.
Topics: Aged; Combined Modality Therapy; Doxapram; Epistaxis; Humans; Male; Respiration, Artificial; Respira | 1994 |
Doxapram hydrochloride in the treatment of acute exacerbation of chronic respiratory failure. A patient with four episodes treated without use of a respirator.
Topics: Carbon Dioxide; Doxapram; Drug Evaluation; Female; Humans; Hydrogen-Ion Concentration; Hypercapnia; | 1978 |
The use of almitrine following potentialized analgesic. Anesthesia based upon alfentanil and flunitrazepam or etomidate.
Topics: Adolescent; Adult; Aged; Almitrine; Analgesics, Opioid; Anesthesia, General; Anesthetics; Blood Gas | 1979 |
Methods and results of assessing the hypoxic ventilatory drive in patients and normal subjects.
Topics: Bronchitis; Carbon Dioxide; Chemoreceptor Cells; Chronic Disease; Diabetic Neuropathies; Doxapram; H | 1979 |
Prolonged doxapram infusion in obesity-hypoventilation syndrome.
Topics: Acute Disease; Adult; Doxapram; Female; Humans; Hypoventilation; Infusions, Parenteral; Obesity; Res | 1978 |
[Responses of patients with chronic respiratory failure to administration of 24 percent oxygen and doxapram infusion (author's transl)].
Topics: Aged; Chronic Disease; Doxapram; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Oxygen In | 1978 |
[Assessment of responses to 24 percent oxygen and respiratory stimulation produced by doxapram hydrochloride (author's transl)].
Topics: Adult; Aged; Animals; Chronic Disease; Dogs; Doxapram; Female; Humans; Male; Middle Aged; Oxygen; Re | 1978 |
[Doxapram. Pharmocokinetic and clinical study].
Topics: Administration, Oral; Blood Pressure; Carbon Dioxide; Doxapram; Drug Evaluation; Humans; Infusions, | 1978 |
Side effects of doxapram infusion.
Topics: Aged; Alcohol Drinking; Doxapram; Female; Hallucinations; Humans; Infusions, Parenteral; Male; Respi | 1976 |
Intravenous diazepam narcosis in the treatment of injuries, with doxapram for recovery.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Child; Diazepam; Doxapram; Female; Fractures, Bone | 1975 |
Acute hypercapnic respiratory failure in patients with chronic obstructive lung disease: risk factors and use of guidelines for management.
Topics: Doxapram; Female; Humans; Hydrogen-Ion Concentration; Hypercapnia; Lung Diseases, Obstructive; Male; | 1992 |
[Respiratory stimulants].
Topics: Aminobutyrates; Doxapram; Humans; Respiratory Insufficiency | 1991 |
Doxapram for respiratory depression after epidural morphine.
Topics: Analgesia, Epidural; Doxapram; Humans; Middle Aged; Morphine; Respiratory Insufficiency | 1990 |
[Doxapram (Dopram). An alternative to respirator treatment in acute episodes of aggravated chronic respiratory insufficiency?].
Topics: Aged; Chronic Disease; Doxapram; Humans; Intermittent Positive-Pressure Ventilation; Male; Respirato | 1986 |
Treatment of acute exacerbation of chronic respiratory failure with doxapram: a case report.
Topics: Aged; Carcinoma, Bronchogenic; Chronic Disease; Combined Modality Therapy; Doxapram; Female; Humans; | 1985 |
The search for a pharmacologic ventilator.
Topics: Anesthesia, General; Arousal; Bemegride; Benzamides; Biopsy; Central Nervous System Stimulants; Doxa | 1966 |
[Doxapram: clinical experience with a new respiratory stimulant].
Topics: Adolescent; Adult; Aged; Body Weight; Central Nervous System Stimulants; Child; Doxapram; Humans; Mi | 1968 |
[Clinical experience with a new analeptic, doxapram hydrochloride ("Doxapril"), in post-anesthetic respiratory depression].
Topics: Adult; Aged; Anesthesia; Central Nervous System Stimulants; Doxapram; Humans; Middle Aged; Morpholin | 1970 |
[Doxapram in respiratory depressions caused by neuroleptoanalgesia of type II].
Topics: Adult; Central Nervous System Stimulants; Doxapram; Electroencephalography; Humans; Morpholines; Neu | 1970 |
[Preliminary report on the activity of orally administered Farmicor on blood circulation and respiration].
Topics: Adult; Amino Alcohols; Blood Circulation; Blood Pressure; Cardiac Volume; Cardiovascular System; Cen | 1971 |
[Doxapram: a new analeptic in the isolated and associated therapy of cardiorespiratory insufficiency in medical practice].
Topics: Arrhythmias, Cardiac; Central Nervous System Stimulants; Digitalis Glycosides; Doxapram; Heart Defec | 1970 |
[Treatment of decompensated chronic respiratory insufficiency with doxapram].
Topics: Aged; Central Nervous System Stimulants; Chronic Disease; Doxapram; Humans; Male; Middle Aged; Morph | 1971 |
[Results using a respiratory analeptic: Dopram in resuscitation].
Topics: Adult; Aged; Central Nervous System Stimulants; Coma; Doxapram; Female; Humans; Injections, Intraven | 1969 |
Experience with the use of doxapram in the treatment of respiratory failure.
Topics: Central Nervous System Stimulants; Doxapram; Humans; Lung Diseases, Obstructive; Morpholines; Oxygen | 1972 |
[Acute decompensation in chronic respiratory failure. Our current therapeutic management].
Topics: Ampicillin; Betamethasone; Breathing Exercises; Central Nervous System Stimulants; Chloramphenicol; | 1972 |
[Application of doxapram in postoperative respiratory depression on the doxapram test].
Topics: Anesthesia; Doxapram; Humans; Postoperative Complications; Respiratory Insufficiency | 1974 |
[Application of doxapram infusion in modified neuroleptanesthesia].
Topics: Adult; Aged; Cataract Extraction; Doxapram; Humans; Middle Aged; Neuroleptanalgesia; Respiratory Ins | 1974 |
Respiratory failure in chronic airways obstruction.
Topics: Aerosols; Anti-Bacterial Agents; Blood Gas Analysis; Chronic Disease; Doxapram; Drainage; Exercise T | 1973 |
[Effects of doxapram in chronic respiratory insufficiency].
Topics: Adult; Aged; Blood Pressure; Bronchitis; Carbon Dioxide; Cardiac Output; Catheterization; Chronic Di | 1972 |
Respiratory stimulants and obstructed airways.
Topics: Airway Obstruction; Doxapram; Humans; Lung Diseases, Obstructive; Oxygen Inhalation Therapy; Respira | 1973 |
Recovery from central respiratory failure and administration of doxapram to a patient with a brainstem lesion.
Topics: Apnea; Brain Stem; Cerebrovascular Disorders; Coma; Doxapram; Female; Humans; Middle Aged; Quadriple | 1973 |
The use of doxapram in the newborn.
Topics: Anesthesia, Obstetrical; Bicarbonates; Birth Weight; Blood; Carbon Dioxide; Doxapram; Female; Gestat | 1973 |
Dimethyl sulfoxide in experimental hypoxic respiratory depression.
Topics: Animals; Benzamides; Dimethyl Sulfoxide; Doxapram; Hypoxia; Male; Nitrogen; Rats; Respiratory Insuff | 1973 |
Response to a respiratory stimulant (doxapram) in severe respiratory failure.
Topics: Aged; Blood; Bronchitis; Carbon Dioxide; Chronic Disease; Coma; Doxapram; Female; Humans; Hydrogen-I | 1974 |
The use of respiratory stimulants in respiratory failure.
Topics: Aminobutyrates; Benzoates; Carbonic Anhydrase Inhibitors; Doxapram; Humans; Nikethamide; Respiratory | 1974 |
Respiratory stimulants.
Topics: Acute Disease; Administration, Oral; Aminobutyrates; Benzamides; Carbon Dioxide; Carbonic Anhydrase | 1972 |