doxapram has been researched along with Pregnancy in 13 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxapram was compared to placebo (saline) in newborn puppies in a randomized, double-blinded clinical trial using two outcome measures: 7-day mortality rate and repeated APGAR score measurements." | 3.30 | The effect of doxapram on survival and APGAR score in newborn puppies delivered by elective caesarean: A randomized controlled trial. ( Aleri, JW; Bowden, RS; Coaicetto, F; Fretwell, S; Hyndman, TH; Irons, PC; Kordzakhia, N; Metcalfe, SS; Mosing, M; Musk, GC; Page, SW; Tuke, SJ, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Hyndman, TH | 1 |
| Fretwell, S | 1 |
| Bowden, RS | 1 |
| Coaicetto, F | 1 |
| Irons, PC | 1 |
| Aleri, JW | 1 |
| Kordzakhia, N | 1 |
| Page, SW | 1 |
| Musk, GC | 1 |
| Tuke, SJ | 1 |
| Mosing, M | 1 |
| Metcalfe, SS | 1 |
| Ramadoss, J | 1 |
| Lunde, ER | 1 |
| Ouyang, N | 1 |
| Chen, WJ | 1 |
| Cudd, TA | 1 |
| Jansen, AH | 1 |
| Ioffe, S | 1 |
| Chernick, V | 1 |
| Wilds, PL | 2 |
| Gay, R | 1 |
| Piercy, WN | 1 |
| Day, MA | 1 |
| Neims, AH | 1 |
| Williams, RL | 1 |
| Hogg, MI | 1 |
| Golding, RH | 1 |
| Rosen, M | 1 |
| Downing, JW | 1 |
| Jeal, DE | 1 |
| Allen, PJ | 1 |
| Buley, R | 1 |
| Bamford, OS | 1 |
| Dawes, GS | 1 |
| Hanson, MA | 1 |
| Ward, RA | 1 |
| Gupta, PK | 1 |
| Moore, J | 1 |
| Kuga, T | 1 |
| Naito, J | 1 |
| Holladay, JR | 1 |
1 review available for doxapram and Pregnancy
| Article | Year |
|---|---|
[The pharmacodynamics of respiratory stimulants (author's transl)].
Topics: Almitrine; Animals; Cardiovascular System; Central Nervous System; Central Nervous System Stimulants | 1979 |
1 trial available for doxapram and Pregnancy
| Article | Year |
|---|---|
The effect of doxapram on survival and APGAR score in newborn puppies delivered by elective caesarean: A randomized controlled trial.
Topics: Animals; Animals, Newborn; Apgar Score; Cesarean Section; Dogs; Doxapram; Female; Litter Size; Pregn | 2023 |
11 other studies available for doxapram and Pregnancy
| Article | Year |
|---|---|
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss.
Topics: Animals; Cell Death; Cerebellum; Disease Models, Animal; Doxapram; Ethanol; Female; Fetal Alcohol Sp | 2008 |
Drug-induced changes in fetal breathing activity and sleep state.
Topics: Animals; Caffeine; Doxapram; Female; Fetus; Indomethacin; Pilocarpine; Pregnancy; Respiration; Sheep | 1983 |
Intrauterine breathing movements.
Topics: Animals; Blood Glucose; Circadian Rhythm; Cold Temperature; Doxapram; Electrocardiography; Female; F | 1980 |
Observations of intrauterine fetal breathing movements--a review.
Topics: Adrenocorticotropic Hormone; Animals; Blood; Blood Glucose; Blood Pressure; Carbon Dioxide; Circadia | 1978 |
Alteration of ovine fetal respiratory-like activity by diazepam, caffeine, and doxapram.
Topics: Animals; Blood Gas Analysis; Caffeine; Depression, Chemical; Diazepam; Doxapram; Female; Fetal Blood | 1977 |
The effect of doxapram on fetal breathing in the sheep.
Topics: Animals; Dose-Response Relationship, Drug; Doxapram; Female; Fetus; Pregnancy; Respiration; Sheep | 1977 |
I.V. doxapram hydrochloride and pulmonary complications after lower abdominal surgery.
Topics: Abdomen; Adult; Carbon Dioxide; Doxapram; Female; Humans; Infusions, Parenteral; Oxygen; Postoperati | 1977 |
The effects of doxapram on breathing, heart rate and blood pressure in fetal lambs.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Doxapram; Female; | 1986 |
The use of doxapram in the newborn.
Topics: Anesthesia, Obstetrical; Bicarbonates; Birth Weight; Blood; Carbon Dioxide; Doxapram; Female; Gestat | 1973 |
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolinone hydrochloride (doxapram). 2. Peripheral action].
Topics: Animals; Autonomic Nervous System; Diaphragm; Doxapram; Female; Gastrointestinal Motility; Guinea Pi | 1974 |
Routine use of doxapram hydrochloride in neonatal pups delivered by cesarean section.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Cesarean Section; Dog Diseases; Dogs; Doxapram; Fema | 1971 |