doxapram has been researched along with Postoperative Complications in 35 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind study patients given a single dose of doxapram 1-5-2-0 mg/kg combined with morphine postoperatively had a significantly lower incidence of reflex postoperative cough and expectoration of purulent sputum than patients given morphine alone." | 5.04 | Role of doxapram in reducing pulmonary complications after major surgery. ( Dundee, JW; Gawley, TH; Gupta, PK; Jones, CJ, 1976) |
| "After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram." | 2.68 | Adverse events with continuous doxapram infusion against late postoperative hypoxaemia. ( Kristensen, PA; Overgaard, H; Pedersen, MH; Rosenberg, J, 1996) |
| "Both doxapram and pethidine were effective in treating postoperative shivering 2-3 min after i." | 2.67 | Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. ( Crossley, AW; Dimitriou, V; Mahajan, RP; Singh, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (77.14) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, D | 1 |
| Chai, W | 1 |
| Sun, X | 1 |
| Yao, L | 1 |
| Drummond, GB | 1 |
| Park, GR | 1 |
| Hunter, AR | 1 |
| Crawford, ME | 1 |
| Carl, P | 1 |
| Ravlo, O | 1 |
| Sebel, PS | 1 |
| Kershaw, EJ | 1 |
| Rao, WS | 1 |
| Vickers, MD | 1 |
| Owen, H | 1 |
| Hutton, P | 1 |
| Hollway, TE | 1 |
| Stanford, BJ | 1 |
| Steele, RJ | 1 |
| Walker, WS | 1 |
| Irvine, MK | 1 |
| Lee, D | 1 |
| Taylor, TV | 1 |
| Owen-Falkenberg, AP | 1 |
| Pagani, I | 1 |
| Ramaioli, F | 1 |
| Marra, M | 1 |
| Benegiamo, M | 1 |
| Singh, P | 2 |
| Dimitriou, V | 1 |
| Mahajan, RP | 2 |
| Crossley, AW | 2 |
| Rosenberg, J | 1 |
| Kristensen, PA | 1 |
| Pedersen, MH | 1 |
| Overgaard, H | 1 |
| Wrench, IJ | 1 |
| Dennis, AR | 1 |
| Illengo, M | 1 |
| Fagiano, G | 1 |
| Calvo, F | 1 |
| Dundee, JW | 5 |
| Gawley, TH | 2 |
| Gupta, PK | 3 |
| Jones, CJ | 3 |
| Downing, JW | 1 |
| Jeal, DE | 1 |
| Allen, PJ | 1 |
| Buley, R | 1 |
| Andersen, R | 1 |
| Krohg, K | 1 |
| Less, NW | 1 |
| Howie, HB | 1 |
| Mellon, A | 1 |
| McKee, AH | 1 |
| McDiarmid, IA | 1 |
| Broome, IJ | 1 |
| Mills, GH | 1 |
| Jansen, JE | 1 |
| Sorensen, AI | 1 |
| Naesh, O | 1 |
| Erichsen, CJ | 1 |
| Pedersen, A | 1 |
| Sarma, V | 1 |
| Fry, EN | 2 |
| Clyburn, PA | 1 |
| Rosen, M | 1 |
| Olsen, KH | 1 |
| Melsen, NC | 1 |
| Thorshauge, H | 1 |
| Christensen, JH | 1 |
| Laxenaire, MC | 1 |
| Boileau, S | 1 |
| Dagrenat, P | 1 |
| Menu, N | 1 |
| Drouet, N | 1 |
| Gilbert, J | 1 |
| Rice, WH | 1 |
| Johnston, J | 1 |
| DelPizzo, A | 1 |
| Vetrò, A | 1 |
| Marukawa, S | 1 |
| Sugiyama, D | 1 |
| Segawa, S | 1 |
| Shibata, T | 1 |
| Hayashi, S | 1 |
| Walker, FS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant[NCT02819089] | 100 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
| Comparison of Two Different Anesthetic Techniques on Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position: A Prospective Randomized Clinical Trial[NCT03572517] | 65 participants (Actual) | Interventional | 2017-09-01 | Completed | |||
| The Effect of Low Flow Anesthesia on Postoperative Emergence Agitation in Rhinoplasty: A Randomized, Controlled Trial[NCT05601674] | 76 participants (Actual) | Interventional | 2022-11-04 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 trials available for doxapram and Postoperative Complications
| Article | Year |
|---|---|
Doxapram and postoperative chest complications.
Topics: Abdomen; Clinical Trials as Topic; Cough; Double-Blind Method; Doxapram; Female; Humans; Lung Diseas | 1983 |
Effects of doxapram on postoperative pulmonary complications following thoracotomy.
Topics: Carbon Dioxide; Doxapram; Female; Humans; Hydrogen-Ion Concentration; Lung; Male; Oxygen; Partial Pr | 1980 |
Doxapram and the fractured femur.
Topics: Aged; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Doxapram; Femoral Neck Fracture | 1982 |
The use of doxapram in the prevention of postoperative pulmonary complications.
Topics: Clinical Trials as Topic; Doxapram; Female; Humans; Lung Diseases; Male; Postoperative Complications | 1982 |
Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering.
Topics: Adolescent; Adult; Anesthesia, General; Double-Blind Method; Doxapram; Female; Humans; Male; Meperid | 1993 |
Adverse events with continuous doxapram infusion against late postoperative hypoxaemia.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Double-Blind Method; Doxapram; Female; Humans; | 1996 |
The minimum effective doses of pethidine and doxapram in the treatment of post-anaesthetic shivering.
Topics: Adolescent; Adult; Analgesics, Opioid; Central Nervous System Stimulants; Dose-Response Relationship | 1997 |
Role of doxapram in reducing pulmonary complications after major surgery.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cough; Doxapram; Female; Humans; Lung Diseases; Male; M | 1976 |
The influence of doxapram on postoperative pulmonary function in patients undergoing upper abdominal surgery.
Topics: Adult; Cholecystectomy; Doxapram; Female; Humans; Hypoxia; Male; Middle Aged; Postoperative Care; Po | 1976 |
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients.
Topics: Abdomen; Adult; Aged; Blood Gas Analysis; Cough; Double-Blind Method; Doxapram; Drug Administration | 1990 |
Doxapram after general anaesthesia. Its role in stopping shivering during recovery.
Topics: Adolescent; Adult; Anesthesia, Inhalation; Doxapram; Female; Humans; Male; Middle Aged; Postoperativ | 1991 |
Patient-controlled analgesia with a mixture of pethidine and doxapram hydrochloride. A comparison of the incidence of respiratory dysrhythmias with pethidine alone.
Topics: Adult; Aged; Apnea; Carbon Dioxide; Doxapram; Drug Therapy, Combination; Female; Humans; Male; Meper | 1988 |
[The effect of doxapram after thoracotomy].
Topics: Clinical Trials as Topic; Double-Blind Method; Doxapram; Humans; Pneumonectomy; Postoperative Compli | 1986 |
Haemodynamic and respiratory effects of post-operative doxapram and almitrine in patients following pneumonectomy.
Topics: Almitrine; Blood Pressure; Bronchial Neoplasms; Doxapram; Hemodynamics; Humans; Male; Myocardial Con | 1986 |
The effect of an infusion of doxapram on morphine analgesia.
Topics: Adolescent; Adult; Aged; Analgesia; Clinical Trials as Topic; Doxapram; Drug Interactions; Humans; I | 1974 |
Opiate analgesia without respiratory depression: a study in postoperative patients.
Topics: Anesthesia, General; Doxapram; Humans; Morphine; Naloxone; Placebos; Postoperative Complications; Re | 1973 |
19 other studies available for doxapram and Postoperative Complications
| Article | Year |
|---|---|
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Doxapram and idiopathic hypoventilation.
Topics: Doxapram; Female; Humans; Middle Aged; Postoperative Complications; Respiratory Insufficiency | 1984 |
[A possible clinical application of doxapram (Dopram). A new respiratory stimulant].
Topics: Anesthesia, Inhalation; Animals; Doxapram; Hemodynamics; Humans; Postoperative Complications; Respir | 1984 |
Postoperative pneumonias.
Topics: Anti-Bacterial Agents; Breathing Exercises; Doxapram; Drainage; Female; Humans; Male; Pneumonia; Pos | 1982 |
Effect of doxapram on postoperative oxygenation in obese patients.
Topics: Adult; Carbon Dioxide; Doxapram; Female; Humans; Hypoxia; Male; Obesity; Oxygen; Partial Pressure; P | 1982 |
[Doxapram hydrochloride. Treatment of postoperative hypoventilation caused by fentanyl].
Topics: Doxapram; Female; Fentanyl; Humans; Hypoventilation; Middle Aged; Postoperative Complications | 1980 |
[The use of doxapram chlorohydrate (t-doxapril) as an anti-shivering drug].
Topics: Body Temperature; Doxapram; Humans; Postoperative Complications; Shivering | 1980 |
[Evaluation of the effectiveness of doxapram in the prevention of postoperative hypoxia in abdominal surgery].
Topics: Abdomen; Adult; Aged; Cholecystectomy; Doxapram; Drug Evaluation; Female; Humans; Hypoxia; Male; Mid | 1979 |
Postoperative chest infections.
Topics: Doxapram; Humans; Postoperative Complications; Respiratory Tract Infections | 1978 |
I.V. doxapram hydrochloride and pulmonary complications after lower abdominal surgery.
Topics: Abdomen; Adult; Carbon Dioxide; Doxapram; Female; Humans; Infusions, Parenteral; Oxygen; Postoperati | 1977 |
Prevention of postoperative pulmonary complications. Intravenous analgesia combined with doxapram.
Topics: Doxapram; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Lung | 1976 |
Proceedings: The role of doxapram in the reduction of pulmonary complications following surgery.
Topics: Adolescent; Adult; Doxapram; Humans; Injections, Intravenous; Middle Aged; Morphine; Naloxone; Posto | 1975 |
Doxapram after general anaesthesia.
Topics: Anesthesia, General; Doxapram; Humans; Postoperative Complications; Shivering | 1992 |
Muscle spasticity.
Topics: Doxapram; Female; Humans; Male; Middle Aged; Muscle Spasticity; Postoperative Complications | 1990 |
Possible doxapram reversal of ventilator dependence in a brain-damaged patient.
Topics: Adult; Brain Damage, Chronic; Carbon Dioxide; Doxapram; Humans; Hydrogen-Ion Concentration; Male; Ox | 1985 |
A new look at respiratory stimulants.
Topics: Central Nervous System Stimulants; Doxapram; Hypoxia; Oxygen Inhalation Therapy; Postoperative Compl | 1973 |
A new analeptic agent: doxapram hydrochloride (Dopram).
Topics: Apnea; Central Nervous System Stimulants; Doxapram; Humans; Postoperative Complications | 1966 |
[Clinical experience with a new analeptic, doxapram hydrochloride ("Doxapril"), in post-anesthetic respiratory depression].
Topics: Adult; Aged; Anesthesia; Central Nervous System Stimulants; Doxapram; Humans; Middle Aged; Morpholin | 1970 |
[Application of doxapram in postoperative respiratory depression on the doxapram test].
Topics: Anesthesia; Doxapram; Humans; Postoperative Complications; Respiratory Insufficiency | 1974 |