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doxapram and Muscle Contraction

doxapram has been researched along with Muscle Contraction in 4 studies

Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McGuire, M1
Carey, MF1
O'Connor, JJ1
Orlowski, M1
Pollard, BJ2
Randall, NP1
Pleuvry, BJ1
Kuga, T1
Naito, J1

Trials

1 trial available for doxapram and Muscle Contraction

ArticleYear
Effect of doxapram on neostigmine evoked antagonism of vecuronium neuromuscular block.
    British journal of anaesthesia, 1992, Volume: 68, Issue:4

    Topics: Adult; Anesthesia, General; Depression, Chemical; Double-Blind Method; Doxapram; Drug Interactions;

1992

Other Studies

3 other studies available for doxapram and Muscle Contraction

ArticleYear
Almitrine and doxapram decrease fatigue and increase subsequent recovery in isolated rat diaphragm.
    Journal of applied physiology (Bethesda, Md. : 1985), 1997, Volume: 83, Issue:1

    Topics: Almitrine; Animals; Diaphragm; Doxapram; Electric Stimulation; In Vitro Techniques; Isometric Contra

1997
Doxapram and the neuromuscular junction.
    British journal of anaesthesia, 1989, Volume: 62, Issue:6

    Topics: Acetylcholinesterase; Animals; Diaphragm; Dose-Response Relationship, Drug; Doxapram; Male; Muscle C

1989
[Pharmacological action of 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolinone hydrochloride (doxapram). 2. Peripheral action].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:2

    Topics: Animals; Autonomic Nervous System; Diaphragm; Doxapram; Female; Gastrointestinal Motility; Guinea Pi

1974