doxapram has been researched along with Hypoxia in 47 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0." | 9.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 9.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "To elucidate the effects of halothane on chemical regulation of ventilation in man, the authors studied the ventilatory responses to isocapnic hypoxia and hyperoxic hypercapnia in 33 human subjects while fully conscious and during sedation or anesthesia with halothane, ." | 7.66 | Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man. ( Gelb, AW; Knill, RL, 1978) |
| "Doxapram was found to be a potent stimulus to the carotid chemoreceptors; the stimulation produced by 1." | 5.25 | Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. ( Herbert, DA; Mitchell, RA, 1975) |
| "Fifteen infants, median gestational age at birth 27 weeks (range 24-30), age at study 27 days (12-60), with >/=6 episodes of bradycardia or hypoxaemia/6 h despite serum caffeine levels in the therapeutic range, received doxapram either intravenously (0." | 5.09 | Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants. ( Bohnhorst, B; Darraj, S; Poets, CF, 1999) |
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 5.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We studied the effects of the ventilatory stimulant doxapram to test the hypothesis that chronic hypoxia increases the translation of carotid body afferent input into ventilatory motor efferent output by the central nervous system." | 3.76 | Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. ( Dinger, B; Fidone, S; He, L; Huey, K; Powell, FL; Wilkinson, KA, 2010) |
| "To determine if doxapram stimulates the carotid body through the same mechanism as hypoxia, we compared the effects of doxapram and hypoxia on isolated-perfused carotid bodies in rabbits." | 3.73 | Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction. ( Kikuchi, K; Nakano, H; Ohsaki, Y; Osanai, S; Takahashi, T, 2005) |
| " During peripheral chemoreceptor stimulation by hypoxia (10% O2 for 30 min) or doxapram (Dox) infusion (2 mg kg-1 (30 min)-1), ventilation was recorded and successively, under the same conditions, the extracellular Glut concentration ([Glut]o) in the caudal NTS was measured by in vivo microdialysis." | 3.69 | In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. ( Hida, W; Kikuchi, Y; Kurosawa, H; Mizusawa, A; Ogawa, H; Okabe, S; Shirato, K; Takishima, T, 1994) |
| "To elucidate the effects of halothane on chemical regulation of ventilation in man, the authors studied the ventilatory responses to isocapnic hypoxia and hyperoxic hypercapnia in 33 human subjects while fully conscious and during sedation or anesthesia with halothane, ." | 3.66 | Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man. ( Gelb, AW; Knill, RL, 1978) |
| "After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90-year-old woman receiving doxapram." | 2.68 | Adverse events with continuous doxapram infusion against late postoperative hypoxaemia. ( Kristensen, PA; Overgaard, H; Pedersen, MH; Rosenberg, J, 1996) |
| "To determine whether CX1942 reverses respiratory depression in etorphine-immobilized goats, and to compare its effects with those of doxapram hydrochloride." | 1.43 | Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats (Capra hircus). ( Fuller, A; Greer, JJ; Haw, AJ; Meyer, LC, 2016) |
| "Etorphine immobilization caused respiratory depression and hypoxia (mean+/-SD, PaCO(2)=51+/-2 mmHg, PaO(2)=40+/-3 mmHg)." | 1.36 | Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). ( Fick, LG; Fuller, A; Hetem, RS; Meyer, LC; Mitchell, D, 2010) |
| "Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear." | 1.33 | Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. ( Lee, LY; Xu, F; Zhou, T; Zhuang, J, 2005) |
| "Doxapram is a respiratory stimulant which acts on peripheral chemoreceptors and central respiratory neurons in a dose-dependent fashion in the adult cat." | 1.29 | Effects of doxapram on carotid chemoreceptor activity in newborn kittens. ( Bairam, A; Crance, JP; Lahiri, S; Marchal, F; Vert, P, 1993) |
| "Doxapram was found to be a potent stimulus to the carotid chemoreceptors; the stimulation produced by 1." | 1.25 | Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. ( Herbert, DA; Mitchell, RA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (61.70) | 18.7374 |
| 1990's | 10 (21.28) | 18.2507 |
| 2000's | 5 (10.64) | 29.6817 |
| 2010's | 3 (6.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haw, AJ | 1 |
| Meyer, LC | 2 |
| Greer, JJ | 1 |
| Fuller, A | 2 |
| Wilkinson, KA | 1 |
| Huey, K | 1 |
| Dinger, B | 1 |
| He, L | 1 |
| Fidone, S | 1 |
| Powell, FL | 1 |
| Hetem, RS | 1 |
| Fick, LG | 1 |
| Mitchell, D | 1 |
| Takahashi, T | 3 |
| Osanai, S | 3 |
| Nakano, H | 3 |
| Ohsaki, Y | 2 |
| Kikuchi, K | 3 |
| Xu, F | 1 |
| Zhuang, J | 1 |
| Zhou, T | 1 |
| Lee, LY | 1 |
| Nishino, T | 2 |
| Yonezawa, T | 1 |
| Honda, Y | 2 |
| Burki, NK | 1 |
| Busch, MA | 1 |
| Bisgard, GE | 4 |
| Mesina, JE | 1 |
| Forster, HV | 3 |
| Gautier, H | 1 |
| Bonora, M | 1 |
| Owen, H | 1 |
| Hutton, P | 1 |
| Hollway, TE | 1 |
| Stanford, BJ | 1 |
| Wilds, PL | 1 |
| Hata, N | 1 |
| Sakakibara, Y | 1 |
| Satomura, Y | 1 |
| Mizusawa, A | 1 |
| Ogawa, H | 2 |
| Kikuchi, Y | 2 |
| Hida, W | 2 |
| Kurosawa, H | 1 |
| Okabe, S | 1 |
| Takishima, T | 1 |
| Shirato, K | 1 |
| Bairam, A | 2 |
| Marchal, F | 2 |
| Hannhart, B | 1 |
| Crance, JP | 2 |
| Lahiri, S | 2 |
| Vert, P | 1 |
| Moorthy, SS | 1 |
| Sullivan, TY | 1 |
| Fallon, JH | 1 |
| Dierdorf, SF | 1 |
| Radpour, S | 1 |
| DeAtley, RE | 1 |
| Rosenberg, J | 1 |
| Kristensen, PA | 1 |
| Pedersen, MH | 1 |
| Overgaard, H | 1 |
| Björk, L | 1 |
| Arborelius, M | 1 |
| Renck, H | 1 |
| Rosberg, B | 1 |
| Poets, CF | 1 |
| Darraj, S | 1 |
| Bohnhorst, B | 1 |
| Ebihara, S | 1 |
| Sasaki, H | 1 |
| Marcq, M | 1 |
| Gepts, L | 1 |
| Erven, W | 1 |
| Minette, A | 1 |
| Flenley, DC | 1 |
| Illengo, M | 1 |
| Fagiano, G | 1 |
| Calvo, F | 1 |
| Knill, RL | 1 |
| Gelb, AW | 1 |
| Rasmussen, B | 1 |
| Orr, JA | 1 |
| Buss, DD | 1 |
| Manohar, M | 1 |
| Less, NW | 1 |
| Howie, HB | 1 |
| Mellon, A | 1 |
| McKee, AH | 1 |
| McDiarmid, IA | 1 |
| Mitchell, RA | 1 |
| Herbert, DA | 1 |
| De Canniere, D | 1 |
| Stefanidis, C | 1 |
| Hallemans, R | 2 |
| Delcroix, M | 2 |
| Brimioulle, S | 2 |
| Naeije, R | 2 |
| Lejeune, P | 1 |
| Vachiéry, JL | 1 |
| Leeman, M | 1 |
| Mélot, C | 1 |
| Mifflin, SW | 1 |
| Beech, J | 1 |
| Nakanishi, S | 1 |
| Hiramoto, T | 1 |
| Ahmed, N | 1 |
| Nishimoto, Y | 1 |
| Yoshikawa, T | 1 |
| Yamamoto, H | 1 |
| Nishimura, M | 1 |
| Kawakami, Y | 1 |
| Von Colditz, JH | 1 |
| Coon, RL | 1 |
| Clifford, PS | 1 |
| Igler, FO | 1 |
| Litwin, SB | 1 |
| Kampine, JP | 1 |
| St John, WM | 1 |
| Bledsoe, TA | 1 |
| DelPizzo, A | 1 |
| De la Torre, JC | 2 |
| Rowed, DW | 2 |
| Dobkin, AB | 1 |
| Su, JP | 1 |
| Byles, PH | 1 |
| Merin, RG | 1 |
| Boba, A | 1 |
| Ruiz, AV | 2 |
| Grover, RF | 2 |
| Will, JA | 2 |
| Dempsey, JA | 1 |
| Vidruk, E | 1 |
| Do Pico, G | 1 |
| Petty, WC | 1 |
| Sulkowski, TS | 1 |
1 review available for doxapram and Hypoxia
| Article | Year |
|---|---|
Respiratory problems in foals.
Topics: Adrenergic beta-Agonists; Aminophylline; Animals; Animals, Newborn; Anti-Bacterial Agents; Asphyxia | 1985 |
6 trials available for doxapram and Hypoxia
| Article | Year |
|---|---|
Doxapram and the fractured femur.
Topics: Aged; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Doxapram; Femoral Neck Fracture | 1982 |
Adverse events with continuous doxapram infusion against late postoperative hypoxaemia.
Topics: Adult; Aged; Aged, 80 and over; Cerebral Infarction; Double-Blind Method; Doxapram; Female; Humans; | 1996 |
Effect of doxapram on episodes of apnoea, bradycardia and hypoxaemia in preterm infants.
Topics: Apnea; Birth Weight; Bradycardia; Caffeine; Doxapram; Drug Resistance; Gestational Age; Humans; Hypo | 1999 |
Doxapram and perception of dyspnea.
Topics: Adult; Doxapram; Dyspnea; Humans; Hypoxia; Male; Middle Aged; Oxygen; Respiratory System Agents; Ris | 2002 |
[Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results].
Topics: Aged; Almitrine; Carbon Dioxide; Central Nervous System Stimulants; Chronic Disease; Doxapram; Human | 1979 |
The influence of doxapram on postoperative pulmonary function in patients undergoing upper abdominal surgery.
Topics: Adult; Cholecystectomy; Doxapram; Female; Humans; Hypoxia; Male; Middle Aged; Postoperative Care; Po | 1976 |
40 other studies available for doxapram and Hypoxia
| Article | Year |
|---|---|
Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats (Capra hircus).
Topics: Analgesics, Opioid; Animals; Doxapram; Etorphine; Female; Goats; Hypoxia; Immobilization; Naltrexone | 2016 |
Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system.
Topics: Afferent Pathways; Animals; Carotid Body; Central Nervous System; Chronic Disease; Denervation; Dise | 2010 |
Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus).
Topics: Analgesics, Opioid; Animals; Animals, Wild; Antelopes; Carbon Dioxide; Doxapram; Etorphine; Hypoxia; | 2010 |
Doxapram stimulates carotid body with different mechanisms from hypoxic chemotransduction.
Topics: Animals; Benzimidazoles; Carotid Body; Chemoreceptor Cells; Doxapram; Electrophysiology; Halothane; | 2003 |
Doxapram inhibits carotid sinus baroreceptors in rabbits.
Topics: Animals; Carotid Body; Carotid Sinus; Central Nervous System Stimulants; Depression, Chemical; Dose- | 2005 |
Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.
Topics: Anesthetics, Inhalation; Animals; Benzimidazoles; Carotid Body; Carotid Sinus; Cromakalim; Dose-Resp | 2005 |
Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.
Topics: Animals; Asthma; Capsaicin; Carbon Dioxide; Carotid Body; Disease Models, Animal; Doxapram; Enzyme I | 2005 |
Properties of spinal accessory nerve activity response to changes in chemical drive.
Topics: Accessory Nerve; Anesthesia, General; Animals; Carbon Dioxide; Cats; Doxapram; Halothane; Hypercapni | 1983 |
Ventilatory effects of doxapram in conscious human subjects.
Topics: Adult; Carbon Dioxide; Chemoreceptor Cells; Consciousness; Doxapram; Humans; Hypercapnia; Hypoxia; I | 1984 |
The effects of unilateral carotid body excision on ventilatory control in goats.
Topics: Acclimatization; Animals; Carotid Body; Chemoreceptor Cells; Dopamine; Doxapram; Female; Goats; Hype | 1983 |
Possible alterations in brain monoamine metabolism during hypoxia-induced tachypnea in cats.
Topics: Aminophylline; Animals; Biogenic Amines; Brain; Caffeine; Carbidopa; Cats; Dihydroxyphenylalanine; D | 1980 |
Effect of doxapram on postoperative oxygenation in obese patients.
Topics: Adult; Carbon Dioxide; Doxapram; Female; Humans; Hypoxia; Male; Obesity; Oxygen; Partial Pressure; P | 1982 |
Intrauterine breathing movements.
Topics: Animals; Blood Glucose; Circadian Rhythm; Cold Temperature; Doxapram; Electrocardiography; Female; F | 1980 |
Central hypoxic-hypercapnic interaction in mild hypoxia in man.
Topics: Adult; Cerebrovascular Circulation; Chemoreceptor Cells; Doxapram; Humans; Hypercapnia; Hypoxia; Mal | 1981 |
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
Topics: Animals; Blood Pressure; Carotid Body; Chemoreceptor Cells; Denervation; Dizocilpine Maleate; Doxapr | 1994 |
Carotid chemosensory response to doxapram in the newborn kitten.
Topics: Action Potentials; Animals; Animals, Newborn; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cell | 1993 |
Effects of doxapram on carotid chemoreceptor activity in newborn kittens.
Topics: Animals; Animals, Newborn; Arteries; Carotid Sinus; Cats; Chemoreceptor Cells; Doxapram; Gases; Halo | 1993 |
Loss of hypoxic ventilatory response following bilateral neck dissection.
Topics: Aged; Dissection; Doxapram; Head and Neck Neoplasms; Humans; Hypoxia; Male; Middle Aged; Neck; Oxyge | 1993 |
Metabolic, ventilatory and circulatory effects of doxapram in anaesthetized pigs during normoxia and hypoxia.
Topics: Anesthesia; Animals; Carbon Dioxide; Central Nervous System Stimulants; Doxapram; Female; Hemodynami | 1996 |
Methods and results of assessing the hypoxic ventilatory drive in patients and normal subjects.
Topics: Bronchitis; Carbon Dioxide; Chemoreceptor Cells; Chronic Disease; Diabetic Neuropathies; Doxapram; H | 1979 |
[Evaluation of the effectiveness of doxapram in the prevention of postoperative hypoxia in abdominal surgery].
Topics: Abdomen; Adult; Aged; Cholecystectomy; Doxapram; Drug Evaluation; Female; Humans; Hypoxia; Male; Mid | 1979 |
Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man.
Topics: Adult; Doxapram; Drug Interactions; Halothane; Humans; Hypercapnia; Hypoxia; Respiration | 1978 |
Ventilatory control in peripheral chemoreceptor-denervated ponies during chronic hypoxemia.
Topics: Acclimatization; Acid-Base Equilibrium; Altitude; Animals; Aortic Bodies; Carbon Dioxide; Carotid Bo | 1976 |
Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats.
Topics: Anesthesia; Animals; Aorta; Blood Pressure; Carbon Dioxide; Carotid Body; Carotid Sinus; Cats; Chlor | 1975 |
Stimulus-response curves for hypoxic pulmonary vasoconstriction in piglets.
Topics: Animals; Aspirin; Blood Pressure; Doxapram; Hypoxia; Pulmonary Artery; Stimulation, Chemical; Swine; | 1992 |
Restored hypoxic pulmonary vasoconstriction by peripheral chemoreceptor agonists in dogs.
Topics: Almitrine; Animals; Blood Pressure; Carbon Dioxide; Chemoreceptor Cells; Dogs; Doxapram; Hemodynamic | 1990 |
Arterial chemoreceptor input to respiratory hypoglossal motoneurons.
Topics: Animals; Carbon Dioxide; Carotid Sinus; Cats; Chemoreceptor Cells; Doxapram; Electric Stimulation; E | 1990 |
Almitrine enhances in low dose the reactivity of pulmonary vessels to hypoxia.
Topics: Almitrine; Animals; Blood Flow Velocity; Central Nervous System Stimulants; Chemoreceptor Cells; Den | 1988 |
Doxapram on blunted respiratory chemosensitivity to hypoxia in hypoxemic, chronic obstructive pulmonary disease.
Topics: Adolescent; Adult; Aged; Bronchitis; Chemoreceptor Cells; Doxapram; Female; Forced Expiratory Flow R | 1987 |
Effects of chronic right-to-left cardiac shunt on hypoxic sensitivity of mongrel dogs.
Topics: Animals; Blood Pressure; Carotid Body; Chemoreceptor Cells; Dogs; Dopamine; Doxapram; Heart Defects, | 1985 |
Comparison of respiratory-related trigeminal, hypoglossal and phrenic activities.
Topics: Animals; Cats; Chemoreceptor Cells; Decerebrate State; Diazepam; Doxapram; Electromyography; Electro | 1985 |
A new look at respiratory stimulants.
Topics: Central Nervous System Stimulants; Doxapram; Hypoxia; Oxygen Inhalation Therapy; Postoperative Compl | 1973 |
DMSO: a new respiratory stimulant?
Topics: Animals; Atmosphere; Benzamides; Dimethyl Sulfoxide; Doxapram; Haplorhini; Hypoxia; Macaca; Male; Mo | 1974 |
The efficacy of managing postanaesthetic respiratory depression with analeptics.
Topics: Abdomen; Adult; Aged; Aminobutyrates; Anesthesia, General; Animals; Arousal; Bemegride; Benzamides; | 1966 |
Electroencephalographic effect of doxapram hydrochloride in humans.
Topics: Adult; Brain; Central Nervous System Stimulants; Doxapram; Electroencephalography; Epilepsy; Female; | 1966 |
Ventilatory acclimatization to 3400 meters altitude in the Hereford calf.
Topics: Acclimatization; Altitude; Animals; Bicarbonates; Biological Transport; Carbon Dioxide; Cardiac Outp | 1974 |
Ventilatory control in the Hereford calf.
Topics: Animals; Carbon Dioxide; Cardiac Output; Cattle; Cyanides; Doxapram; Female; Hydrogen-Ion Concentrat | 1973 |
Dimethyl sulfoxide in experimental hypoxic respiratory depression.
Topics: Animals; Benzamides; Dimethyl Sulfoxide; Doxapram; Hypoxia; Male; Nitrogen; Rats; Respiratory Insuff | 1973 |
Evidence of altered regulation of ventilation during exposure to hypoxia.
Topics: Acclimatization; Acidosis; Acidosis, Respiratory; Altitude; Doxapram; Humans; Hypoxia; Male; Physica | 1974 |
CO 2 narcosis in the rat. II. Effects on the ECG.
Topics: Animals; Arrhythmias, Cardiac; Carbon Dioxide; Doxapram; Electrocardiography; Heart; Heart Block; He | 1971 |