Page last updated: 2024-10-26

doxapram and Hypoventilation

doxapram has been researched along with Hypoventilation in 7 studies

Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Hypoventilation: A reduction in the amount of air entering the pulmonary alveoli.

Research Excerpts

ExcerptRelevanceReference
"Doxapram is a respiratory stimulating drug that affects both peripheral chemoreceptors and medullary respiratory and nonrespiratory neurons."5.26Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome. ( Hunt, CE; Inwood, RJ; Shannon, DC, 1979)
"Doxapram is a respiratory stimulating drug that affects both peripheral chemoreceptors and medullary respiratory and nonrespiratory neurons."1.26Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome. ( Hunt, CE; Inwood, RJ; Shannon, DC, 1979)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Richards, JR1
Laurin, EG1
Bretz, SW1
Traylor, BR1
Panacek, EA1
Owen-Falkenberg, AP1
Marsac, J1
Bouchoucha, S1
Ruff, F1
Hunt, CE1
Inwood, RJ1
Shannon, DC1
Houser, WC1
Schlueter, DP1
Haddad, GG1
Mazza, NM1
Defendini, R1
Blanc, WA1
Driscoll, JM1
Epstein, MA1
Epstein, RA1
Mellins, RB1
Jansen, JE1
Sorensen, AI1
Naesh, O1
Erichsen, CJ1
Pedersen, A1

Reviews

1 review available for doxapram and Hypoventilation

ArticleYear
[The treatment of chronic alveolar hypoventilation (not including physiotherapy and artificial ventilation) (author's transl)].
    Bulletin europeen de physiopathologie respiratoire, 1979, Volume: 15 Suppl

    Topics: Almitrine; Bronchodilator Agents; Carbonic Anhydrase Inhibitors; Central Nervous System; Central Ner

1979

Trials

1 trial available for doxapram and Hypoventilation

ArticleYear
Effect of doxapram on postoperative pulmonary complications after upper abdominal surgery in high-risk patients.
    Lancet (London, England), 1990, Apr-21, Volume: 335, Issue:8695

    Topics: Abdomen; Adult; Aged; Blood Gas Analysis; Cough; Double-Blind Method; Doxapram; Drug Administration

1990

Other Studies

5 other studies available for doxapram and Hypoventilation

ArticleYear
Treatment of ethanol poisoning and associated hypoventilation with doxapram.
    The American journal of emergency medicine, 2016, Volume: 34, Issue:11

    Topics: Central Nervous System Stimulants; Doxapram; Emergency Service, Hospital; Ethanol; Humans; Hypoventi

2016
[Doxapram hydrochloride. Treatment of postoperative hypoventilation caused by fentanyl].
    Ugeskrift for laeger, 1980, Sep-15, Volume: 142, Issue:38

    Topics: Doxapram; Female; Fentanyl; Humans; Hypoventilation; Middle Aged; Postoperative Complications

1980
Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome.
    The American review of respiratory disease, 1979, Volume: 119, Issue:2

    Topics: Chemical and Drug Induced Liver Injury; Doxapram; Duodenal Ulcer; Dyskinesia, Drug-Induced; Humans;

1979
Prolonged doxapram infusion in obesity-hypoventilation syndrome.
    JAMA, 1978, Jan-23, Volume: 239, Issue:4

    Topics: Acute Disease; Adult; Doxapram; Female; Humans; Hypoventilation; Infusions, Parenteral; Obesity; Res

1978
Congenital failure of automatic control of ventilation, gastrointestinal motility and heart rate.
    Medicine, 1978, Volume: 57, Issue:6

    Topics: Doxapram; Female; Heart Rate; Humans; Hypoventilation; Infant, Newborn; Megacolon; Respiration; Resp

1978