Page last updated: 2024-10-26

doxapram and Hypothermia

doxapram has been researched along with Hypothermia in 4 studies

Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and at two levels of hypothermia."7.65Effects of cyanide and doxapram during hypothermia. ( Ruiz, AV, 1975)
"The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and at two levels of hypothermia."3.65Effects of cyanide and doxapram during hypothermia. ( Ruiz, AV, 1975)
"When doxapram was given intraperitoneally 60 min."1.28Interaction of doxapram and pentobarbital in mice. ( Ishikawa, M; Ozaki, M; Sasaki, K; Suzuki, I; Takayanagi, Y, 1991)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ruiz, AV1
Abdallah, AH1
Roby, DM1
Ishikawa, M1
Suzuki, I1
Ozaki, M1
Takayanagi, Y1
Sasaki, K1

Other Studies

4 other studies available for doxapram and Hypothermia

ArticleYear
Effects of cyanide and doxapram during hypothermia.
    Pflugers Archiv : European journal of physiology, 1975, Dec-19, Volume: 361, Issue:1

    Topics: Animals; Arteries; Carbon Dioxide; Chemoreceptor Cells; Cyanides; Dogs; Doxapram; Female; Hydrogen-I

1975
Antagonism of depressant activity of ethanol by DH-524; a comparative study with Bemegride, Doxapram and d-amphetamine.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 148, Issue:3

    Topics: Amphetamine; Animals; Bemegride; Depression, Chemical; Doxapram; Ethanol; Humans; Hypothermia; Imida

1975
Perioperative shivering.
    Lancet (London, England), 1991, Aug-31, Volume: 338, Issue:8766

    Topics: Anesthesia; Body Temperature Regulation; Doxapram; Humans; Hypothermia; Intraoperative Complications

1991
Interaction of doxapram and pentobarbital in mice.
    Pharmacology & toxicology, 1991, Volume: 69, Issue:4

    Topics: Animals; Blood Proteins; Brain; Cytochrome P-450 Enzyme System; Doxapram; Drug Interactions; Guinea

1991