doxapram has been researched along with Hypercapnia in 25 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 9.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We report three cases in which doxapram hydrochloride injection was used as an additional method of treating and stabilizing patients with chronic hypercapnia and hypoxia." | 7.69 | Use of doxapram hydrochloride injection as an alternative to intubation to treat chronic obstructive pulmonary disease patients with hypercapnia. ( Dupper, RL; Hirshberg, AJ, 1994) |
| "To elucidate the effects of halothane on chemical regulation of ventilation in man, the authors studied the ventilatory responses to isocapnic hypoxia and hyperoxic hypercapnia in 33 human subjects while fully conscious and during sedation or anesthesia with halothane, ." | 7.66 | Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man. ( Gelb, AW; Knill, RL, 1978) |
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 5.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We report three cases in which doxapram hydrochloride injection was used as an additional method of treating and stabilizing patients with chronic hypercapnia and hypoxia." | 3.69 | Use of doxapram hydrochloride injection as an alternative to intubation to treat chronic obstructive pulmonary disease patients with hypercapnia. ( Dupper, RL; Hirshberg, AJ, 1994) |
| "To elucidate the effects of halothane on chemical regulation of ventilation in man, the authors studied the ventilatory responses to isocapnic hypoxia and hyperoxic hypercapnia in 33 human subjects while fully conscious and during sedation or anesthesia with halothane, ." | 3.66 | Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man. ( Gelb, AW; Knill, RL, 1978) |
| "Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear." | 1.33 | Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. ( Lee, LY; Xu, F; Zhou, T; Zhuang, J, 2005) |
| "Doxapram is a respiratory stimulant which acts on peripheral chemoreceptors and central respiratory neurons in a dose-dependent fashion in the adult cat." | 1.29 | Effects of doxapram on carotid chemoreceptor activity in newborn kittens. ( Bairam, A; Crance, JP; Lahiri, S; Marchal, F; Vert, P, 1993) |
| "A 51-year-old woman with chronic respiratory failure (status after tuberculosis) was given an infusion of doxapram hydrochloride (1 to 2 mg/kg of body weight per hour) for four episodes of acute exacerbation of her condition." | 1.26 | Doxapram hydrochloride in the treatment of acute exacerbation of chronic respiratory failure. A patient with four episodes treated without use of a respirator. ( Heki, S; Kato, M; Nakashima, M; Ohi, M; Sagawa, Y, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (72.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, F | 1 |
| Zhuang, J | 1 |
| Zhou, T | 1 |
| Lee, LY | 1 |
| Nishino, T | 2 |
| Yonezawa, T | 1 |
| Honda, Y | 2 |
| Burki, NK | 1 |
| Gautier, H | 2 |
| Bonora, M | 2 |
| Wilds, PL | 1 |
| Ohsugi, T | 1 |
| Hata, N | 1 |
| Sakakibara, Y | 1 |
| Satomura, Y | 1 |
| Hirshberg, AJ | 1 |
| Dupper, RL | 1 |
| Bairam, A | 2 |
| Marchal, F | 2 |
| Hannhart, B | 1 |
| Crance, JP | 2 |
| Lahiri, S | 2 |
| Vert, P | 1 |
| Miyamoto, M | 1 |
| Miyamoto, T | 1 |
| Hirata, K | 1 |
| Ohi, M | 1 |
| Nakashima, M | 1 |
| Heki, S | 1 |
| Kato, M | 1 |
| Sagawa, Y | 1 |
| Marcq, M | 1 |
| Gepts, L | 1 |
| Erven, W | 1 |
| Minette, A | 1 |
| Milic-Emili, J | 1 |
| Siafakas, NM | 1 |
| Flenley, DC | 2 |
| Knill, RL | 1 |
| Gelb, AW | 1 |
| Conti, F | 1 |
| Bertoli, L | 1 |
| Mantero, O | 1 |
| Jeffrey, AA | 1 |
| Warren, PM | 1 |
| Pourriat, JL | 2 |
| Baud, M | 2 |
| Lamberto, C | 2 |
| Fosse, JP | 1 |
| Cupa, M | 2 |
| Hoang, P | 1 |
| Aitkaci, F | 1 |
| Vasseur, B | 1 |
| Yoshikawa, T | 1 |
| Yamamoto, H | 1 |
| Nishimura, M | 1 |
| Kawakami, Y | 1 |
| St John, WM | 1 |
| Bledsoe, TA | 1 |
| Bisgard, GE | 2 |
| Ruiz, AV | 2 |
| Grover, RF | 2 |
| Will, JA | 2 |
| Petty, WC | 1 |
| Sulkowski, TS | 1 |
2 reviews available for doxapram and Hypercapnia
| Article | Year |
|---|---|
[Hypercapnic coma(CO2 narcosis)].
Topics: Central Nervous System Stimulants; Coma; Diagnosis, Differential; Doxapram; Humans; Hypercapnia; Oxy | 2000 |
[Treatment of acute hypercapnic respiratory insufficiency in chronic obstructive bronchopneumopathy. New trends in controlled oxygen therapy].
Topics: Adult; Aged; Aminophylline; Chronic Disease; Doxapram; Female; Humans; Hypercapnia; Lung Diseases, O | 1975 |
1 trial available for doxapram and Hypercapnia
| Article | Year |
|---|---|
[Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results].
Topics: Aged; Almitrine; Carbon Dioxide; Central Nervous System Stimulants; Chronic Disease; Doxapram; Human | 1979 |
22 other studies available for doxapram and Hypercapnia
| Article | Year |
|---|---|
Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.
Topics: Animals; Asthma; Capsaicin; Carbon Dioxide; Carotid Body; Disease Models, Animal; Doxapram; Enzyme I | 2005 |
Properties of spinal accessory nerve activity response to changes in chemical drive.
Topics: Accessory Nerve; Anesthesia, General; Animals; Carbon Dioxide; Cats; Doxapram; Halothane; Hypercapni | 1983 |
Ventilatory effects of doxapram in conscious human subjects.
Topics: Adult; Carbon Dioxide; Chemoreceptor Cells; Consciousness; Doxapram; Humans; Hypercapnia; Hypoxia; I | 1984 |
Possible alterations in brain monoamine metabolism during hypoxia-induced tachypnea in cats.
Topics: Aminophylline; Animals; Biogenic Amines; Brain; Caffeine; Carbidopa; Cats; Dihydroxyphenylalanine; D | 1980 |
Intrauterine breathing movements.
Topics: Animals; Blood Glucose; Circadian Rhythm; Cold Temperature; Doxapram; Electrocardiography; Female; F | 1980 |
[Studies on hypercapnia in patients with lung tuberculosis (author's transl)].
Topics: Blood Gas Analysis; Carbonic Anhydrase Inhibitors; Doxapram; Humans; Hypercapnia; Lung Volume Measur | 1980 |
Central hypoxic-hypercapnic interaction in mild hypoxia in man.
Topics: Adult; Cerebrovascular Circulation; Chemoreceptor Cells; Doxapram; Humans; Hypercapnia; Hypoxia; Mal | 1981 |
Use of doxapram hydrochloride injection as an alternative to intubation to treat chronic obstructive pulmonary disease patients with hypercapnia.
Topics: Aged; Blood Gas Analysis; Doxapram; Female; Humans; Hypercapnia; Infusions, Intravenous; Lung Diseas | 1994 |
Carotid chemosensory response to doxapram in the newborn kitten.
Topics: Action Potentials; Animals; Animals, Newborn; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cell | 1993 |
Effects of doxapram on carotid chemoreceptor activity in newborn kittens.
Topics: Animals; Animals, Newborn; Arteries; Carotid Sinus; Cats; Chemoreceptor Cells; Doxapram; Gases; Halo | 1993 |
Doxapram hydrochloride in the treatment of acute exacerbation of chronic respiratory failure. A patient with four episodes treated without use of a respirator.
Topics: Carbon Dioxide; Doxapram; Drug Evaluation; Female; Humans; Hydrogen-Ion Concentration; Hypercapnia; | 1978 |
[Ventilatory effects of various respiratory stimulants in awake cats (author's transl)].
Topics: Almitrine; Animals; Caffeine; Carbon Dioxide; Cats; Central Nervous System; Central Nervous System S | 1979 |
Methods and results of assessing the hypoxic ventilatory drive in patients and normal subjects.
Topics: Bronchitis; Carbon Dioxide; Chemoreceptor Cells; Chronic Disease; Diabetic Neuropathies; Doxapram; H | 1979 |
Ventilatory responses to hypoxia and hypercapnia during halothane sedation and anesthesia in man.
Topics: Adult; Doxapram; Drug Interactions; Halothane; Humans; Hypercapnia; Hypoxia; Respiration | 1978 |
Acute hypercapnic respiratory failure in patients with chronic obstructive lung disease: risk factors and use of guidelines for management.
Topics: Doxapram; Female; Humans; Hydrogen-Ion Concentration; Hypercapnia; Lung Diseases, Obstructive; Male; | 1992 |
Effects of doxapram on hypercapnic response during weaning from mechanical ventilation in COPD patients.
Topics: Aged; Carbon Dioxide; Doxapram; Female; Humans; Hypercapnia; Infusions, Intravenous; Lung Diseases, | 1992 |
[Effects of doxapram on the response to hypercapnia: application to weaning from artificial ventilation in chronic obstructive respiratory insufficiency].
Topics: Aged; Doxapram; Humans; Hypercapnia; Lung Diseases, Obstructive; Middle Aged; Ventilator Weaning | 1989 |
Doxapram on blunted respiratory chemosensitivity to hypoxia in hypoxemic, chronic obstructive pulmonary disease.
Topics: Adolescent; Adult; Aged; Bronchitis; Chemoreceptor Cells; Doxapram; Female; Forced Expiratory Flow R | 1987 |
Comparison of respiratory-related trigeminal, hypoglossal and phrenic activities.
Topics: Animals; Cats; Chemoreceptor Cells; Decerebrate State; Diazepam; Doxapram; Electromyography; Electro | 1985 |
Ventilatory acclimatization to 3400 meters altitude in the Hereford calf.
Topics: Acclimatization; Altitude; Animals; Bicarbonates; Biological Transport; Carbon Dioxide; Cardiac Outp | 1974 |
Ventilatory control in the Hereford calf.
Topics: Animals; Carbon Dioxide; Cardiac Output; Cattle; Cyanides; Doxapram; Female; Hydrogen-Ion Concentrat | 1973 |
CO 2 narcosis in the rat. II. Effects on the ECG.
Topics: Animals; Arrhythmias, Cardiac; Carbon Dioxide; Doxapram; Electrocardiography; Heart; Heart Block; He | 1971 |