doxapram has been researched along with Disease Models, Animal in 7 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Doxapram is an analeptic capable of inducing panic attacks with respiratory symptoms in individuals diagnosed with the disorder; however, its neuroanatomical targets and its effects on experimental animals remain uncharacterized." | 8.02 | Intravenous doxapram administration as a potential model of panic attacks in rats. ( Batista, LA; Brianis, RC; Haibara, AS; Lopes, JB; Moreira, FA, 2021) |
| " Doxapram is an analeptic capable of inducing panic attacks with respiratory symptoms in individuals diagnosed with the disorder; however, its neuroanatomical targets and its effects on experimental animals remain uncharacterized." | 4.02 | Intravenous doxapram administration as a potential model of panic attacks in rats. ( Batista, LA; Brianis, RC; Haibara, AS; Lopes, JB; Moreira, FA, 2021) |
| " A total of 17 prioritized drugs, based on efficacy in in vitro screens, were chosen for further evaluation in a murine model of pneumonic plague to delineate if in vitro efficacy could be translated in vivo Three drugs, doxapram (DXP), amoxapine (AXPN), and trifluoperazine (TFP), increased animal survivability despite not exhibiting any direct bacteriostatic or bactericidal effect on Y." | 3.83 | New Role for FDA-Approved Drugs in Combating Antibiotic-Resistant Bacteria. ( Andersson, JA; Chauhan, S; Chopra, AK; Dann, SM; Fitts, EC; Kirtley, ML; Motin, VL; Peniche, AG; Ponnusamy, D; Rosenzweig, JA; Sha, J, 2016) |
| "We studied the effects of the ventilatory stimulant doxapram to test the hypothesis that chronic hypoxia increases the translation of carotid body afferent input into ventilatory motor efferent output by the central nervous system." | 3.76 | Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. ( Dinger, B; Fidone, S; He, L; Huey, K; Powell, FL; Wilkinson, KA, 2010) |
| "Doxapram at 4 mg/kg increased anxiety-related behaviors in all four anxiety models." | 3.72 | Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala. ( Apergis, J; Gorman, JM; LeDoux, JE; Sullivan, GM, 2003) |
| "Patients with chronic bronchial asthma show a depressed ventilatory response to hypoxia (DVH), but the underlying mechanism remains unclear." | 1.33 | Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. ( Lee, LY; Xu, F; Zhou, T; Zhuang, J, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Batista, LA | 1 |
| Lopes, JB | 1 |
| Brianis, RC | 1 |
| Haibara, AS | 1 |
| Moreira, FA | 1 |
| Andersson, JA | 1 |
| Fitts, EC | 1 |
| Kirtley, ML | 1 |
| Ponnusamy, D | 1 |
| Peniche, AG | 1 |
| Dann, SM | 1 |
| Motin, VL | 1 |
| Chauhan, S | 1 |
| Rosenzweig, JA | 1 |
| Sha, J | 1 |
| Chopra, AK | 1 |
| Ramadoss, J | 1 |
| Lunde, ER | 1 |
| Ouyang, N | 1 |
| Chen, WJ | 1 |
| Cudd, TA | 1 |
| Wilkinson, KA | 1 |
| Huey, K | 1 |
| Dinger, B | 1 |
| He, L | 1 |
| Fidone, S | 1 |
| Powell, FL | 1 |
| Yoshida, T | 1 |
| Uchiyama, A | 1 |
| Matsuura, N | 1 |
| Mashimo, T | 1 |
| Fujino, Y | 1 |
| Sullivan, GM | 1 |
| Apergis, J | 1 |
| Gorman, JM | 1 |
| LeDoux, JE | 1 |
| Xu, F | 1 |
| Zhuang, J | 1 |
| Zhou, T | 1 |
| Lee, LY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Neuromuscular Blocking Agents on End Expiratory Lung Volume During Moderate-severe ARDS[NCT04996394] | 15 participants (Actual) | Observational | 2019-12-12 | Completed | |||
| Airway Occlusion Measured During Non-invasive Ventilation to Assess Respiratory Effort[NCT05576246] | 12 participants (Anticipated) | Observational | 2022-10-30 | Not yet recruiting | |||
| Driving Pressure Variation During Proportional Assisted Ventilation: Comparison Between NAVA and PSV[NCT03719365] | 20 participants (Anticipated) | Interventional | 2018-11-01 | Recruiting | |||
| PRessure suppOrT vEntilation + Sigh in aCuTe hypoxemIc respiratOry Failure patieNts (PROTECTION): a Pilot Randomized Controlled Trial[NCT03201263] | 258 participants (Actual) | Interventional | 2017-12-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for doxapram and Disease Models, Animal
| Article | Year |
|---|---|
Intravenous doxapram administration as a potential model of panic attacks in rats.
Topics: Administration, Intravenous; Alprazolam; Animals; Benzamides; Carbamates; Central Nervous System Sti | 2021 |
New Role for FDA-Approved Drugs in Combating Antibiotic-Resistant Bacteria.
Topics: Amoxapine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Clostridioides difficile | 2016 |
Acid-sensitive channel inhibition prevents fetal alcohol spectrum disorders cerebellar Purkinje cell loss.
Topics: Animals; Cell Death; Cerebellum; Disease Models, Animal; Doxapram; Ethanol; Female; Fetal Alcohol Sp | 2008 |
Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system.
Topics: Afferent Pathways; Animals; Carotid Body; Central Nervous System; Chronic Disease; Denervation; Dise | 2010 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury.
Topics: Acute Lung Injury; Acute-Phase Proteins; Animals; Bronchoalveolar Lavage; Bronchoalveolar Lavage Flu | 2013 |
Rodent doxapram model of panic: behavioral effects and c-Fos immunoreactivity in the amygdala.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain; Central Nervous System Stimulants; Conditioning | 2003 |
Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs.
Topics: Animals; Asthma; Capsaicin; Carbon Dioxide; Carotid Body; Disease Models, Animal; Doxapram; Enzyme I | 2005 |