Page last updated: 2024-10-26

doxapram and Coma

doxapram has been researched along with Coma in 8 studies

Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"A specific arousal therapy with NAGD (Naloxone, Activated Charcoal, Glucagon, Doxapram) is outlined for victims of drug overdose in comatose and semi-comatose states."3.66NAGD regimen for the coma of drug-related overdose. ( Decker, WJ; Gay, GR; Inaba, DS; Rappolt, RT, 1980)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Richards, JR1
Davis, MT1
Curry, MR1
Tsushima, JH1
McKinney, HE1
Rappolt, RT2
Gay, GR2
Decker, WJ1
Inaba, DS1
Inaba, D1
Miyamoto, M1
Miyamoto, T1
Hirata, K1
Ohresser, P1
Leonardelli, M1
Lareng, L1
Vaysse, C1
Cathala, B1
Plaut, MR1
Gifford, RR1
Jacobsen, PM1
Riordan, JF1
Sillett, RW1
McNicol, MW1

Reviews

1 review available for doxapram and Coma

ArticleYear
[Hypercapnic coma(CO2 narcosis)].
    Ryoikibetsu shokogun shirizu, 2000, Issue:29 Pt 4

    Topics: Central Nervous System Stimulants; Coma; Diagnosis, Differential; Doxapram; Humans; Hypercapnia; Oxy

2000

Other Studies

7 other studies available for doxapram and Coma

ArticleYear
Doxapram reversal of suspected gamma-hydroxybutyrate-induced coma.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:3

    Topics: Adjuvants, Anesthesia; Administration, Intravenous; Aged; Central Nervous System Stimulants; Coma; D

2017
NAGD regimen for the coma of drug-related overdose.
    Annals of emergency medicine, 1980, Volume: 9, Issue:7

    Topics: Charcoal; Coma; Doxapram; Drug Therapy, Combination; Glucagon; Humans; Injections, Intravenous; Nalo

1980
NAGD regime [naloxone (Narcan), activated charcoal, glucagon, doxapram (Dopram)] for the coma of drug-related overdoses.
    Clinical toxicology, 1980, Volume: 16, Issue:3

    Topics: Charcoal; Coma; Doxapram; Drug Administration Schedule; Glucagon; Humans; Naloxone; Poisoning

1980
[Results using a respiratory analeptic: Dopram in resuscitation].
    Marseille medical, 1969, Volume: 106, Issue:11

    Topics: Adult; Aged; Central Nervous System Stimulants; Coma; Doxapram; Female; Humans; Injections, Intraven

1969
[Use of doxapram hydrochloride in the treatment of drug toxic comas].
    Cahiers d'anesthesiologie, 1971, Volume: 19, Issue:8

    Topics: Adult; Central Nervous System Stimulants; Coma; Doxapram; Female; Humans; Male; Middle Aged; Morphol

1971
Recovery from central respiratory failure and administration of doxapram to a patient with a brainstem lesion.
    Anesthesiology, 1973, Volume: 38, Issue:6

    Topics: Apnea; Brain Stem; Cerebrovascular Disorders; Coma; Doxapram; Female; Humans; Middle Aged; Quadriple

1973
Response to a respiratory stimulant (doxapram) in severe respiratory failure.
    British journal of diseases of the chest, 1974, Volume: 68, Issue:1

    Topics: Aged; Blood; Bronchitis; Carbon Dioxide; Chronic Disease; Coma; Doxapram; Female; Humans; Hydrogen-I

1974