doxapram has been researched along with Chronic Illness in 18 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 9.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We compared the effects of almitrine and doxapram on the arterial blood gases and ventilation of patients with chronic respiratory insufficiency and chronic hypercapnia and hypoxemia." | 5.04 | [Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results]. ( Erven, W; Gepts, L; Marcq, M; Minette, A, 1979) |
| "We studied the effects of the ventilatory stimulant doxapram to test the hypothesis that chronic hypoxia increases the translation of carotid body afferent input into ventilatory motor efferent output by the central nervous system." | 3.76 | Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. ( Dinger, B; Fidone, S; He, L; Huey, K; Powell, FL; Wilkinson, KA, 2010) |
| "Acute-on-chronic respiratory failure is becoming an increasingly common medical emergency, mostly as a result of exacerbations of chronic obstructive pulmonary disease." | 2.44 | Managing acute on chronic respiratory failure: a guide to non-invasive ventilation. ( Goldring, JJ; Wedzicha, JA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldring, JJ | 1 |
| Wedzicha, JA | 1 |
| Wilkinson, KA | 1 |
| Huey, K | 1 |
| Dinger, B | 1 |
| He, L | 1 |
| Fidone, S | 1 |
| Powell, FL | 1 |
| Spector, R | 1 |
| Kishi, F | 1 |
| Murao, M | 1 |
| Marcq, M | 1 |
| Gepts, L | 1 |
| Erven, W | 1 |
| Minette, A | 1 |
| Flenley, DC | 1 |
| Ohi, M | 2 |
| Hamamoto, Y | 1 |
| Tateishi, S | 1 |
| Nakashima, M | 1 |
| Heki, S | 1 |
| Orita, Y | 1 |
| Fujita, M | 1 |
| Asai, N | 1 |
| Kato, M | 1 |
| Sagawa, Y | 1 |
| Conti, F | 2 |
| Bertoli, L | 2 |
| Bertoli, M | 1 |
| Mantero, O | 2 |
| Riordan, JF | 2 |
| Sillett, RW | 2 |
| McNicol, MW | 2 |
| Ravlo, O | 1 |
| Carl, P | 1 |
| Crawford, M | 1 |
| Bach, V | 1 |
| Romanic, BM | 1 |
| Lattin, NE | 1 |
| Warembourg, H | 1 |
| Peltier, JM | 1 |
| Vasseur, P | 1 |
| Norman, JR | 1 |
| Proctor, CA | 1 |
| Conerly, AW | 1 |
| Labrousse, J | 1 |
| Farhad, B | 1 |
| Lissac, J | 1 |
2 reviews available for doxapram and Chronic Illness
| Article | Year |
|---|---|
Managing acute on chronic respiratory failure: a guide to non-invasive ventilation.
Topics: Acute Disease; Aged; Anti-Bacterial Agents; Chronic Disease; Cystic Fibrosis; Doxapram; Humans; Midd | 2008 |
[Treatment of acute hypercapnic respiratory insufficiency in chronic obstructive bronchopneumopathy. New trends in controlled oxygen therapy].
Topics: Adult; Aged; Aminophylline; Chronic Disease; Doxapram; Female; Humans; Hypercapnia; Lung Diseases, O | 1975 |
3 trials available for doxapram and Chronic Illness
| Article | Year |
|---|---|
[Effect of almitrine on arterial gases in patients with chronic respiratory insufficiency. Comparison with doxapram. Preliminary results].
Topics: Aged; Almitrine; Carbon Dioxide; Central Nervous System Stimulants; Chronic Disease; Doxapram; Human | 1979 |
Ventilatory and pulmonary hemodynamic response to the respiratory stimulant doxapram in chronic bronchitis.
Topics: Aged; Blood Pressure; Bronchitis; Chronic Disease; Clinical Trials as Topic; Doxapram; Female; Heart | 1976 |
A controlled trail of doxapram in acute respiratory failure.
Topics: Acute Disease; Aged; Bronchitis; Carbon Dioxide; Catheterization; Chronic Disease; Clinical Trials a | 1975 |
13 other studies available for doxapram and Chronic Illness
| Article | Year |
|---|---|
Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system.
Topics: Afferent Pathways; Animals; Carotid Body; Central Nervous System; Chronic Disease; Denervation; Dise | 2010 |
Treatment of moderate & severe chronic pain syndromes with morphine & adjunctive drugs.
Topics: Amphetamine; Chronic Disease; Cocaine; Doxapram; Histamine H1 Antagonists; Humans; Morphine; Narcoti | 1981 |
[Respiratory stimulant (author's transl)].
Topics: Chronic Disease; Doxapram; Humans; Respiratory Insufficiency | 1981 |
Methods and results of assessing the hypoxic ventilatory drive in patients and normal subjects.
Topics: Bronchitis; Carbon Dioxide; Chemoreceptor Cells; Chronic Disease; Diabetic Neuropathies; Doxapram; H | 1979 |
[Responses of patients with chronic respiratory failure to administration of 24 percent oxygen and doxapram infusion (author's transl)].
Topics: Aged; Chronic Disease; Doxapram; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Oxygen In | 1978 |
[Assessment of responses to 24 percent oxygen and respiratory stimulation produced by doxapram hydrochloride (author's transl)].
Topics: Adult; Aged; Animals; Chronic Disease; Dogs; Doxapram; Female; Humans; Male; Middle Aged; Oxygen; Re | 1978 |
[Doxapram (Dopram). An alternative to respirator treatment in acute episodes of aggravated chronic respiratory insufficiency?].
Topics: Aged; Chronic Disease; Doxapram; Humans; Intermittent Positive-Pressure Ventilation; Male; Respirato | 1986 |
Treatment of acute exacerbation of chronic respiratory failure with doxapram: a case report.
Topics: Aged; Carcinoma, Bronchogenic; Chronic Disease; Combined Modality Therapy; Doxapram; Female; Humans; | 1985 |
[Treatment of decompensated chronic respiratory insufficiency with doxapram].
Topics: Aged; Central Nervous System Stimulants; Chronic Disease; Doxapram; Humans; Male; Middle Aged; Morph | 1971 |
Respiratory failure in chronic airways obstruction.
Topics: Aerosols; Anti-Bacterial Agents; Blood Gas Analysis; Chronic Disease; Doxapram; Drainage; Exercise T | 1973 |
[Effects of doxapram in chronic respiratory insufficiency].
Topics: Adult; Aged; Blood Pressure; Bronchitis; Carbon Dioxide; Cardiac Output; Catheterization; Chronic Di | 1972 |
Response to a respiratory stimulant (doxapram) in severe respiratory failure.
Topics: Aged; Blood; Bronchitis; Carbon Dioxide; Chronic Disease; Coma; Doxapram; Female; Humans; Hydrogen-I | 1974 |
Respiratory stimulants.
Topics: Acute Disease; Administration, Oral; Aminobutyrates; Benzamides; Carbon Dioxide; Carbonic Anhydrase | 1972 |