doxapram has been researched along with Chemical and Drug Induced Liver Injury in 6 studies
Doxapram: A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
doxapram : A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the first case of acute hepatic necrosis, which we believe to have been caused by the administration of the respiratory stimulant, doxapram hydrochloride (Dopram)." | 7.67 | Hepatic necrosis with doxapram hydrochloride. ( Ashton, RJ; Fancourt, GJ; Talbot, IC; Wales, JM, 1985) |
| "Doxapram is a respiratory stimulating drug that affects both peripheral chemoreceptors and medullary respiratory and nonrespiratory neurons." | 5.26 | Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome. ( Hunt, CE; Inwood, RJ; Shannon, DC, 1979) |
| "We report the first case of acute hepatic necrosis, which we believe to have been caused by the administration of the respiratory stimulant, doxapram hydrochloride (Dopram)." | 3.67 | Hepatic necrosis with doxapram hydrochloride. ( Ashton, RJ; Fancourt, GJ; Talbot, IC; Wales, JM, 1985) |
| "Doxapram is a respiratory stimulating drug that affects both peripheral chemoreceptors and medullary respiratory and nonrespiratory neurons." | 1.26 | Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome. ( Hunt, CE; Inwood, RJ; Shannon, DC, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Kanno, S | 2 |
| Ishikawa, M | 2 |
| Takayanagi, M | 2 |
| Takayanagi, Y | 2 |
| Sasaki, K | 2 |
| Hunt, CE | 1 |
| Inwood, RJ | 1 |
| Shannon, DC | 1 |
| Fancourt, GJ | 1 |
| Ashton, RJ | 1 |
| Talbot, IC | 1 |
| Wales, JM | 1 |
1 review available for doxapram and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
5 other studies available for doxapram and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Potentiation of acetaminophen hepatotoxicity and mortality by doxapram in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Central Nervous System Stimulants; Chemical and Dr | 1998 |
Combination acetaminophen and doxapram potentiated hepatotoxicity in mouse primary cultured hepatocytes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Apoptosis; Calcium; Cell Survival; C | 1999 |
Respiratory and nonrespiratory effects of doxapram in congenital central hypoventilation syndrome.
Topics: Chemical and Drug Induced Liver Injury; Doxapram; Duodenal Ulcer; Dyskinesia, Drug-Induced; Humans; | 1979 |
Hepatic necrosis with doxapram hydrochloride.
Topics: Aged; Chemical and Drug Induced Liver Injury; Doxapram; Humans; Liver Diseases; Male; Necrosis | 1985 |