dothiepin-hydrochloride and Testicular-Diseases

Selective necrosis of rat testicles is known to be produced by cadmium in subtoxic doses due to impairment of vessel structures. Classical antihistaminics in the same time in order to exclude that the lesion might have been produced by local release of histamine. Antihistaminics did not prevent necrosis. Instead, Clemastine stressed an interstitial testicular haemorrhage a bit. Methyldosulepine administered with calcium could decrease the vascular permeability because haemorrhage was almost lacking. The finding supports an idea of possible interaction between calcium and cadmium ions.

Topics: Animals; Cadmium; Clemastine; Dibenzothiepins; Dothiepin; Histamine H1 Antagonists; Male; Necrosis; Pyrrolidines; Rats; Sugar Acids; Testicular Diseases; Testis