dothiepin-hydrochloride and Stomach-Ulcer

dothiepin-hydrochloride has been researched along with Stomach-Ulcer* in 1 studies

Other Studies

1 other study(ies) available for dothiepin-hydrochloride and Stomach-Ulcer

ArticleYear
Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
    Life sciences, 2000, Volume: 66, Issue:23

    Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation. Antisecretory studies in pyloric ligated rats revealed that the drug at a dose of 100 mg/kg significantly reduced total acidity, gastric output and protein content. In another set of experiments, dothiepin significantly reduced gastric output, total acidity and protein content in pyloric ligated rats which received 50% alcohol (v/v) 30 minutes after the administration of dothiepin.

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Dothiepin; Eicosanoids; Ethanol; Indomethacin; Ligation; Male; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological

2000