dothiepin-hydrochloride and Diabetic-Neuropathies

In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.

Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dothiepin; Female; Injections, Intraperitoneal; Male; Pain; Pain Measurement; Random Allocation; Rats; Rats, Inbred Strains