dothiepin-hydrochloride and Adjustment-Disorders

The validity of the general neurotic syndrome, a combination of anxiety, depression and dependent personality disorder, was examined in a 2-year study of outpatients with dysthymic, panic and generalized anxiety disorder diagnosed using a structured interview schedule. The general neurotic syndrome, found in a third of the patients, was associated with greater mental disorder and a significantly worse outcome than patients without the syndrome. It did not, however, predict response to treatment. Further analysis revealed that the general neurotic syndrome was a better predictor of short- and long-term outcome than any other variable apart from initial psychopathology score. It is argued that the syndrome may represent a personality diathesis that makes the individual more vulnerable to both anxiety and depressive symptoms.

Topics: Adjustment Disorders; Anxiety Disorders; Cognitive Behavioral Therapy; Depressive Disorder; Diazepam; Dothiepin; England; Follow-Up Studies; Humans; Life Change Events; Neurotic Disorders; Panic Disorder; Personality Disorders; Psychiatric Status Rating Scales; Self Care

Topics: Adjustment Disorders; Adult; Aged; Circadian Rhythm; Depressive Disorder; Dibenzazepines; Dibenzothiepins; Dothiepin; Female; Humans; Hypochondriasis; Male; Mianserin; Middle Aged; Obsessive-Compulsive Disorder; Paranoid Disorders; Sleep Initiation and Maintenance Disorders

Topics: Adjustment Disorders; Adolescent; Adult; Aged; Clinical Trials as Topic; Dibenzothiepins; Dothiepin; Double-Blind Method; Doxepin; Female; Heart Diseases; Humans; Male; Middle Aged; Psychiatric Status Rating Scales

Topics: Adjustment Disorders; Adolescent; Adult; Aged; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depression; Depressive Disorder, Major; Dibenzothiepins; Dothiepin; Drug Tolerance; Female; Humans; Male; Middle Aged; Motor Activity; Sleep Wake Disorders; Thymus Gland

Fifteen patients on dothiepin and 20 on other tricyclic compounds were compared for side effects by self-rating. The high incidence of complaints beforehand and overall reduction during 2 weeks treatment, correlating with clinical improvement, shows that comparison of side effects is unreliable unless pretreatment incidence is recorded.

Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Dibenzothiepins; Dothiepin; Female; Humans; Male; Middle Aged

Topics: Adjustment Disorders; Adolescent; Adult; Aged; Dibenzothiepins; Dothiepin; Doxepin; Female; Humans; Male; Middle Aged