dorzolamide and Metaplasia

To evaluate the changes in conjunctival impression cytology specimens from patients receiving various topical antiglaucoma medications.. Cross-sectional comparative study.. Impression cytology specimens were obtained from the eyes taking no topical medication (n = 20) and from the eyes taking various antiglaucoma medications (timolol n = 34; latanoprost n = 40; dorzolamide n = 32; timolol + latanoprost n = 30; timolol + dorzolamide n = 34). Specimens were graded on a scale of zero to three according to Nelson's method.. Cytology scores were significantly higher in the medication group than the control group. Mean cytology scores of the control, timolol, latanoprost, dorzolamide, timolol + latanoprost, and timolol + dorzolamide group were 0.20, 1.62, 2.00, 1.75, 2.13, and 2.44, respectively. Among the medication groups, cytology scores were significantly lower in the monotherapy group than the fixed-combination therapy group.. Various topical antiglaucoma medications induce a significant degree of squamous metaplasia. Conjunctival surface could be altered after the long-term use of antiglaucoma medication.

Topics: Administration, Topical; Antihypertensive Agents; Conjunctiva; Cross-Sectional Studies; Drug Therapy, Combination; Epithelium; Glaucoma, Open-Angle; Humans; Latanoprost; Metaplasia; Prostaglandins F, Synthetic; Sulfonamides; Thiophenes; Timolol