donepezil hydrochloride has been researched along with Alzheimer Disease in 5 studies
donepezil hydrochloride : A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased." | 1.46 | N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. ( Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ashraf Ali, M | 1 |
| Ismail, R | 1 |
| Choon, TS | 1 |
| Kumar, RS | 1 |
| Osman, H | 1 |
| Arumugam, N | 1 |
| Almansour, AI | 1 |
| Elumalai, K | 1 |
| Singh, A | 1 |
| Baharloo, F | 1 |
| Moslemin, MH | 1 |
| Nadri, H | 1 |
| Asadipour, A | 1 |
| Mahdavi, M | 1 |
| Emami, S | 1 |
| Firoozpour, L | 1 |
| Mohebat, R | 1 |
| Shafiee, A | 1 |
| Foroumadi, A | 1 |
| Košak, U | 1 |
| Knez, D | 1 |
| Coquelle, N | 1 |
| Brus, B | 1 |
| Pišlar, A | 1 |
| Nachon, F | 1 |
| Brazzolotto, X | 1 |
| Kos, J | 1 |
| Colletier, JP | 1 |
| Gobec, S | 1 |
| Wang, W | 2 |
| Yao, G | 1 |
| Ren, Q | 1 |
| Wang, D | 1 |
| Wang, Z | 1 |
| Liu, P | 1 |
| Gao, P | 1 |
| Zhang, Y | 1 |
| Wang, S | 1 |
| Song, S | 1 |
| Zhang, Z | 1 |
| Guo, J | 1 |
| Cheng, M | 1 |
| Zhou, W | 1 |
| Wan, Y | 1 |
| Wang, R | 1 |
| Fang, Y | 1 |
| Jin, Y | 1 |
| Liu, J | 1 |
| Xie, SS | 1 |
5 other studies available for donepezil hydrochloride and Alzheimer Disease
| Article | Year |
|---|---|
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase In | 2012 |
Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzofurans; Cholinesterase Inhibitors; Drug Design; Humans | 2015 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinestera | 2017 |
Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: Design, synthesis and biological evaluation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anemarrhena; Animals; Apoptosis; Cell Line; Drug Design; H | 2018 |
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphen | 2021 |