donepezil has been researched along with Torsade de Pointes in 8 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system." | 5.35 | Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. ( Hiramatsu, Y; Koga, S; Tanaka, A, 2009) |
| "Hydroxychloroquine has been widely prescribed to treat patients with COVID-19 pneumonia." | 1.62 | Torsades de pointes in SARS-CoV-2 (COVID-19) pneumonia: medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications. ( Ali, N; Aslam, W; Lamb, CR, 2021) |
| "To investigate spontaneous reports of TdP present in the public version of the FDA Adverse Event Reporting System (AERS) in the light of what is already known on their TdP-liability." | 1.35 | Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS). ( De Ponti, F; Moretti, U; Poluzzi, E; Raschi, E, 2009) |
| "Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system." | 1.35 | Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes. ( Hiramatsu, Y; Koga, S; Tanaka, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, J | 1 |
| Obejero-Paz, CA | 1 |
| Myatt, G | 1 |
| Kuryshev, YA | 1 |
| Bruening-Wright, A | 1 |
| Verducci, JS | 1 |
| Brown, AM | 1 |
| Aslam, W | 1 |
| Lamb, CR | 1 |
| Ali, N | 1 |
| Malik, BH | 1 |
| Kitt, J | 1 |
| Irons, R | 1 |
| Al-Obaidi, M | 1 |
| Missouris, C | 1 |
| Poluzzi, E | 1 |
| Raschi, E | 1 |
| Moretti, U | 1 |
| De Ponti, F | 1 |
| Tanaka, A | 1 |
| Koga, S | 1 |
| Hiramatsu, Y | 1 |
| Takaya, T | 1 |
| Okamoto, M | 1 |
| Yodoi, K | 1 |
| Hata, K | 1 |
| Kijima, Y | 1 |
| Nakajima, H | 1 |
| Nishikawa, Y | 1 |
| Kita, T | 1 |
| Ito, M | 1 |
| Seo, T | 1 |
| Kawashima, S | 1 |
| Shinozaki, K | 1 |
8 other studies available for donepezil and Torsade de Pointes
| Article | Year |
|---|---|
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp T | 2013 |
Torsades de pointes in SARS-CoV-2 (COVID-19) pneumonia: medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications.
Topics: Aged; Anti-Infective Agents; Citalopram; COVID-19 Drug Treatment; Dexamethasone; Donepezil; Drug The | 2021 |
Donepezil - QT prolongation and torsades de pointes.
Topics: Accidental Falls; Arrhythmias, Cardiac; Donepezil; Humans; Long QT Syndrome; Torsades de Pointes | 2019 |
A case of donepezil-related torsades de pointes.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiopulmonary Resuscitation; Donepezil; Electrocardiography; | 2015 |
Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS).
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Bacterial Agents; Antidepressive Agents; A | 2009 |
Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes.
Topics: Aged, 80 and over; Atrioventricular Block; Cholinesterase Inhibitors; Donepezil; Female; Humans; Ind | 2009 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiogr | 2009 |
[Shortening of donepezil-induced QTc prolongation with a change in the interacting drug, after electrocardiograph monitoring by community pharmacists: a case report].
Topics: Aged, 80 and over; Amlodipine; Cholinesterase Inhibitors; Community Pharmacy Services; Dihydropyridi | 2012 |