donepezil has been researched along with Syncope in 11 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with AD treated with donepezil, a noninvasive evaluation identified a probable cause of syncope in over two-thirds of patients." | 7.73 | Causes of syncope in patients with Alzheimer's disease treated with donepezil. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Reynard, C; Robert, F, 2005) |
| " The drug was administered at a dosage of 5 mg/day for 1 month and 10 mg/day for the following 7 months, as tolerated." | 6.72 | Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Margaine, J; Robert, F, 2006) |
| "Donepezil is a commonly used drug in older people that due to its procholinergic effects can provoke bradycardia and neurocardiogenic syncope." | 3.78 | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. ( Anderson, GM; Daneman, N; Fischer, HD; Gill, SS; Gruneir, A; Hutson, JR; Rochon, PA; Wang, X, 2012) |
| "In patients with AD treated with donepezil, a noninvasive evaluation identified a probable cause of syncope in over two-thirds of patients." | 3.73 | Causes of syncope in patients with Alzheimer's disease treated with donepezil. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Reynard, C; Robert, F, 2005) |
| "We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil)." | 3.72 | Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors. ( Barold, SS; Bordier, P; Bressolles, N; Clémenty, J; Garrigue, S; Lanusse, S, 2003) |
| "There was no association with accidental injuries or fractures." | 3.01 | Cholinesterase inhibitors and falls, syncope and injuries in patients with cognitive impairment: a systematic review and meta-analysis. ( Ahuja, M; Gabor, C; Karimi, A; Lee, J; Lewis, K; Patterson, C; Reppas-Rindlisbacher, C; Siddhpuria, S; Sood, E; Wong, E, 2023) |
| " The drug was administered at a dosage of 5 mg/day for 1 month and 10 mg/day for the following 7 months, as tolerated." | 2.72 | Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Margaine, J; Robert, F, 2006) |
| "His only medical history was mild Alzheimer's disease diagnosed 6 months prior." | 2.52 | Upper gastrointestinal bleed associated with cholinesterase inhibitor use. ( Kok, KS; Loke, Y; Southgate, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ahuja, M | 1 |
| Siddhpuria, S | 1 |
| Karimi, A | 1 |
| Lewis, K | 1 |
| Wong, E | 1 |
| Lee, J | 1 |
| Reppas-Rindlisbacher, C | 1 |
| Sood, E | 1 |
| Gabor, C | 1 |
| Patterson, C | 1 |
| Jackson, EG | 1 |
| Stowe, S | 1 |
| Kok, KS | 1 |
| Loke, Y | 1 |
| Southgate, J | 1 |
| Kitt, J | 1 |
| Irons, R | 1 |
| Al-Obaidi, M | 1 |
| Missouris, C | 1 |
| Takaya, T | 1 |
| Okamoto, M | 1 |
| Yodoi, K | 1 |
| Hata, K | 1 |
| Kijima, Y | 1 |
| Nakajima, H | 1 |
| Nishikawa, Y | 1 |
| Kita, T | 1 |
| Ito, M | 1 |
| Seo, T | 1 |
| Kawashima, S | 1 |
| Hutson, JR | 1 |
| Fischer, HD | 1 |
| Wang, X | 1 |
| Gruneir, A | 1 |
| Daneman, N | 1 |
| Gill, SS | 1 |
| Rochon, PA | 1 |
| Anderson, GM | 1 |
| McLaren, AT | 1 |
| Allen, J | 1 |
| Murray, A | 1 |
| Ballard, CG | 1 |
| Kenny, RA | 1 |
| Bordier, P | 3 |
| Garrigue, S | 3 |
| Barold, SS | 1 |
| Bressolles, N | 1 |
| Lanusse, S | 3 |
| Clémenty, J | 1 |
| Jane Newby, V | 1 |
| Anne Kenny, R | 1 |
| McKeith, IG | 1 |
| Reynard, C | 1 |
| Robert, F | 2 |
| Gencel, L | 2 |
| Lafitte, A | 2 |
| Margaine, J | 1 |
2 reviews available for donepezil and Syncope
| Article | Year |
|---|---|
Cholinesterase inhibitors and falls, syncope and injuries in patients with cognitive impairment: a systematic review and meta-analysis.
Topics: Accidental Falls; Accidental Injuries; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; | 2023 |
Upper gastrointestinal bleed associated with cholinesterase inhibitor use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Duodenal Ulcer; Endoscop | 2015 |
2 trials available for donepezil and Syncope
| Article | Year |
|---|---|
Cardiovascular effects of donepezil in patients with dementia.
Topics: Aged; Autonomic Nervous System; Cardiovascular System; Cholinesterase Inhibitors; Dementia; Donepezi | 2003 |
Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Pressure; Cardiovascular System; Cholinesterase In | 2006 |
7 other studies available for donepezil and Syncope
| Article | Year |
|---|---|
Lesson of the month 1: Prolonged QT syndrome due to donepezil: a reversible cause of falls?
Topics: Accidental Falls; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Long QT Syndrome; | 2019 |
A case of donepezil-related torsades de pointes.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiopulmonary Resuscitation; Donepezil; Electrocardiography; | 2015 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiogr | 2009 |
Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrioventricular Block; Bradycardia; Cardiovascular | 2012 |
Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Femal | 2003 |
Donepezil and cardiac syncope: case report.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electrocardiography, Ambulatory; Fema | 2004 |
Causes of syncope in patients with Alzheimer's disease treated with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; In | 2005 |