donepezil has been researched along with Sleep Wake Disorders in 15 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson's disease (PD), we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil, 5 mg at bedtime for two months, in the treatment of these complications." | 9.10 | Donepezil in the treatment of hallucinations and delusions in Parkinson's disease. ( Aurilia, C; Barbanti, P; Fabbrini, G; Lenzi, GL; Meco, G; Pauletti, C, 2002) |
| "A severe intractable delirium caused by the basal forebrain vascular lesion and its dramatic recovery after donepezil administration were reported." | 7.72 | Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil. ( Higashima, M; Kidani, T; Kobayashi, K; Koshino, Y; Mutou, K; Tachibana, O; Yamashita, J, 2004) |
| "Donepezil can increase the amount of time that children with an ASD spend in the REM sleep state." | 6.76 | An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. ( Buckley, AW; Buckley, J; Jennison, K; Rodriguez, AJ; Sassower, K; Sato, S; Swedo, S; Thurm, A; Wingert, K, 2011) |
| "As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson's disease (PD), we conducted an open study in 8 PD patients to assess the efficacy and tolerability of the cholinesterase inhibitor donepezil, 5 mg at bedtime for two months, in the treatment of these complications." | 5.10 | Donepezil in the treatment of hallucinations and delusions in Parkinson's disease. ( Aurilia, C; Barbanti, P; Fabbrini, G; Lenzi, GL; Meco, G; Pauletti, C, 2002) |
| "A severe intractable delirium caused by the basal forebrain vascular lesion and its dramatic recovery after donepezil administration were reported." | 3.72 | Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil. ( Higashima, M; Kidani, T; Kobayashi, K; Koshino, Y; Mutou, K; Tachibana, O; Yamashita, J, 2004) |
| "Donepezil can increase the amount of time that children with an ASD spend in the REM sleep state." | 2.76 | An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders. ( Buckley, AW; Buckley, J; Jennison, K; Rodriguez, AJ; Sassower, K; Sato, S; Swedo, S; Thurm, A; Wingert, K, 2011) |
| "Whilst dementia has long been synonymous with AD, it is becoming more widely accepted as part of the clinical spectrum in PD (PDD)." | 2.53 | Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia. ( Lewis, SJ; Szeto, JY, 2016) |
| " Three head-to-head trials of ChEIs in the treatment of AD have been published to date, but are limited due to their open-label design, rates of titration, and the drug dosage levels utilised." | 2.42 | The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease. ( Herrmann, N; Lanctôt, KL; Thompson, S, 2004) |
| "Donepezil is a potent, selective inhibitor of acetylcholinesterase, and selective inhibition of central as opposed to peripheral ChEs might be expected to reduce the incidence of AEs, thus this may explain the lower incidence of cholinergic AEs observed following treatment with donepezil, compared with nonselective ChE inhibitors." | 2.42 | The safety and tolerability of donepezil in patients with Alzheimer's disease. ( Ham, RJ; Jackson, S; Wilkinson, D, 2004) |
| "Treatments in Alzheimer's disease include treatment of cognitive impairment and behavioral manifestations (agitation, depression, anxiety, delusions)." | 1.30 | [Drug therapy strategies in Alzheimer's disease]. ( Lacomblez, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naharci, MI | 1 |
| Ozturk, A | 1 |
| Yasar, H | 1 |
| Cintosun, U | 1 |
| Kocak, N | 1 |
| Bozoglu, E | 1 |
| Tasci, I | 1 |
| Doruk, H | 1 |
| Yin, Y | 1 |
| Liu, Y | 1 |
| Zhuang, J | 1 |
| Pan, X | 1 |
| Li, P | 1 |
| Yang, Y | 1 |
| Li, YP | 1 |
| Zhao, ZQ | 1 |
| Huang, LQ | 1 |
| Zhao, ZX | 1 |
| Szeto, JY | 1 |
| Lewis, SJ | 1 |
| Ishida, T | 2 |
| Kamei, C | 2 |
| Takeda, Y | 1 |
| Hirase, M | 1 |
| Buckley, AW | 1 |
| Sassower, K | 1 |
| Rodriguez, AJ | 1 |
| Jennison, K | 1 |
| Wingert, K | 1 |
| Buckley, J | 1 |
| Thurm, A | 1 |
| Sato, S | 1 |
| Swedo, S | 1 |
| Fabbrini, G | 1 |
| Barbanti, P | 1 |
| Aurilia, C | 1 |
| Pauletti, C | 1 |
| Lenzi, GL | 1 |
| Meco, G | 1 |
| Stahl, SM | 1 |
| Markowitz, JS | 1 |
| Gutterman, EM | 1 |
| Papadopoulos, G | 1 |
| Thompson, S | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Jackson, S | 1 |
| Ham, RJ | 1 |
| Wilkinson, D | 1 |
| Mizuno, S | 1 |
| Kameda, A | 1 |
| Inagaki, T | 1 |
| Horiguchi, J | 1 |
| Kobayashi, K | 1 |
| Higashima, M | 1 |
| Mutou, K | 1 |
| Kidani, T | 1 |
| Tachibana, O | 1 |
| Yamashita, J | 1 |
| Koshino, Y | 1 |
| Cooke, JR | 1 |
| Loredo, JS | 1 |
| Liu, L | 1 |
| Marler, M | 1 |
| Corey-Bloom, J | 1 |
| Fiorentino, L | 1 |
| Harrison, T | 1 |
| Ancoli-Israel, S | 1 |
| Ross, JS | 1 |
| Shua-Haim, JR | 1 |
| Lacomblez, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cognitive Benefits of Treating Apnea in Dementia[NCT00477828] | 61 participants (Actual) | Interventional | 2000-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for donepezil and Sleep Wake Disorders
| Article | Year |
|---|---|
Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Cognitive Behavioral Th | 2016 |
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseas | 2004 |
The safety and tolerability of donepezil in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cholinesterase Inhibitors; Donepezil; Drug Interactions; | 2004 |
5 trials available for donepezil and Sleep Wake Disorders
| Article | Year |
|---|---|
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Hum | 2015 |
An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders.
Topics: Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Developmental Di | 2011 |
Donepezil in the treatment of hallucinations and delusions in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Basal Nucleus of Meynert; Cholinergic Fibers; Cholinesterase Inhibitors; De | 2002 |
Effects of donepezil on Alzheimer's disease: the relationship between cognitive function and rapid eye movement sleep.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; | 2004 |
Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Galantamin | 2006 |
7 other studies available for donepezil and Sleep Wake Disorders
| Article | Year |
|---|---|
Galantamine improves sleep quality in patients with dementia.
Topics: Aged; Aged, 80 and over; Chi-Square Distribution; Cholinesterase Inhibitors; Dementia; Donepezil; Do | 2015 |
Characteristic effects of anti-dementia drugs on rat sleep patterns.
Topics: Animals; Dementia; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Electromyogr | 2009 |
[Effects of anti-dementia drugs on sleep-wake patterns in sleep-disturbed rats].
Topics: Animals; Donepezil; Galantamine; Indans; Male; Nootropic Agents; Piperidines; Piracetam; Rats; Rats, | 2009 |
Co-use of donepezil and hypnotics among Alzheimer's disease patients living in the community.
Topics: Aged; Alzheimer Disease; Caregivers; Chi-Square Distribution; Cholinesterase Inhibitors; Cross-Secti | 2003 |
Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil.
Topics: Aged; Basal Ganglia Cerebrovascular Disease; Basal Nucleus of Meynert; Craniopharyngioma; Delirium; | 2004 |
Aricept-induced nightmares in Alzheimer's disease: 2 case reports.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dreams; Female; Hu | 1998 |
[Drug therapy strategies in Alzheimer's disease].
Topics: Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Car | 1998 |