donepezil has been researched along with Sensitivity and Specificity in 27 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "12 patients with mild to moderate Alzheimer's disease and six controls were studied." | 2.71 | A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease. ( Bolt, L; Fleming, J; Hoffmann, S; Holmes, C; Kemp, PM; Thom, J; Wilkinson, DG; Wilkinson, S; Zivanovic, M, 2003) |
| "Donepezil is a cholinesterase inhibitor which has been previously shown to affect the cognitive evoked potentials (EPs) of patients with Alzheimer's Disease (AD) during treatment with the drug." | 2.70 | The effects of donepezil on quantitative EEG in patients with Alzheimer's disease. ( Patrick, G; Reeves, RR; Struve, FA, 2002) |
| " The method was successfully applied to a pharmacokinetic study involving intramuscular application of 3." | 1.43 | An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study. ( Korabecny, J; Kuca, K; Mzik, M; Nepovimova, E; Palička, V; Voříšek, V; Zdarova Karasova, J, 2016) |
| " The proposed method was successfully applied for the estimation of the drug in real time plasma samples for pharmacokinetic studies." | 1.37 | A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-o-desmethyl donepezil in human plasma and its pharmacokinetic application. ( Damaramadugu, R; Inamadugu, JK; Karra, VK; Kondreddy, N; Pilli, NR; Rao, JV, 2011) |
| "Available treatments for Alzheimer's disease (AD) need to be evaluated in order to determine whether the clinical benefits justify their additional costs." | 1.35 | Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease. ( García-Pérez, L; Hart, W; Linertová, R; López-Bastida, J, 2009) |
| " Higher dosages often did not exert beneficial effects in accordance with inverted U-shaped dose-response curves described for cholinomimetics." | 1.33 | Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. ( Abramowski, D; De Deyn, PP; Staufenbiel, M; Van Dam, D, 2005) |
| " The assay method also shows good specificity to donepezil enantiomers, and it could be successfully applied to its pharmacokinetic studies and to therapeutic drug monitoring." | 1.33 | Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats. ( Abdine, HH; Aboul-Enein, HY; Al-Quadeb, BT; Nakashima, K; Radwan, MA, 2006) |
| " The validated LC/MS/MS method was applied to a pharmacokinetic study in which healthy Chinese volunteers each received a single oral dose of 5 mg donepezil hydrochloride." | 1.33 | Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. ( Liao, Q; Liu, D; Wan, J; Xie, Z; Xu, X; Yao, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 19 (70.37) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zdarova Karasova, J | 2 |
| Sestak, V | 1 |
| Korabecny, J | 2 |
| Mezeiova, E | 1 |
| Palicka, V | 2 |
| Kuca, K | 2 |
| Mzik, M | 2 |
| Ragab, GH | 1 |
| Bahgat, EA | 1 |
| Nepovimova, E | 1 |
| Voříšek, V | 1 |
| Yeh, HH | 1 |
| Yang, YH | 1 |
| Ko, JY | 1 |
| Chen, SH | 1 |
| Shah, HJ | 1 |
| Kundlik, ML | 1 |
| Pandya, A | 1 |
| Prajapati, S | 1 |
| Subbaiah, G | 1 |
| Patel, CN | 1 |
| Patel, DM | 1 |
| Suhagia, BN | 1 |
| Suhagiya, BN | 1 |
| Patel, BN | 1 |
| Sharma, N | 1 |
| Sanyal, M | 1 |
| Shrivastav, PS | 1 |
| López-Bastida, J | 1 |
| Hart, W | 1 |
| García-Pérez, L | 1 |
| Linertová, R | 1 |
| Pietrzak, RH | 1 |
| Maruff, P | 1 |
| Snyder, PJ | 1 |
| Hanyu, H | 2 |
| Sato, T | 2 |
| Hirao, K | 2 |
| Kanetaka, H | 2 |
| Iwamoto, T | 2 |
| Koizumi, K | 2 |
| Pilli, NR | 1 |
| Inamadugu, JK | 1 |
| Kondreddy, N | 1 |
| Karra, VK | 1 |
| Damaramadugu, R | 1 |
| Rao, JV | 1 |
| Zhang, Y | 1 |
| Tingley, FD | 1 |
| Tseng, E | 1 |
| Tella, M | 1 |
| Yang, X | 1 |
| Groeber, E | 1 |
| Liu, J | 1 |
| Li, W | 1 |
| Schmidt, CJ | 1 |
| Steenwyk, R | 1 |
| Koeber, R | 1 |
| Kluenemann, HH | 1 |
| Waimer, R | 1 |
| Koestlbacher, A | 1 |
| Wittmann, M | 1 |
| Brandl, R | 1 |
| Doerfelt, A | 1 |
| Jahner, T | 1 |
| Melchner, D | 1 |
| Haen, E | 1 |
| Brown, D | 1 |
| Chisholm, JA | 1 |
| Owens, J | 1 |
| Pimlott, S | 1 |
| Patterson, J | 1 |
| Wyper, D | 1 |
| Kemp, PM | 1 |
| Holmes, C | 1 |
| Hoffmann, S | 1 |
| Wilkinson, S | 1 |
| Zivanovic, M | 1 |
| Thom, J | 1 |
| Bolt, L | 1 |
| Fleming, J | 1 |
| Wilkinson, DG | 1 |
| Jagust, W | 1 |
| Van Dam, D | 1 |
| Abramowski, D | 1 |
| Staufenbiel, M | 1 |
| De Deyn, PP | 1 |
| Radwan, MA | 1 |
| Abdine, HH | 1 |
| Al-Quadeb, BT | 1 |
| Aboul-Enein, HY | 1 |
| Nakashima, K | 1 |
| Asakawa, Y | 1 |
| Ozawa, C | 1 |
| Osada, K | 1 |
| Kaneko, S | 1 |
| Asakawa, N | 1 |
| Abbas, SS | 1 |
| Fayez, YM | 1 |
| Abdel Fattah, Lel-S | 1 |
| Xie, Z | 1 |
| Liao, Q | 1 |
| Xu, X | 1 |
| Yao, M | 1 |
| Wan, J | 1 |
| Liu, D | 1 |
| Murai, T | 1 |
| Okuda, S | 1 |
| Tanaka, T | 1 |
| Ohta, H | 1 |
| Shimizu, S | 1 |
| Akai, T | 1 |
| Jönsson, L | 1 |
| Lindgren, P | 1 |
| Wimo, A | 1 |
| Jönsson, B | 1 |
| Winblad, B | 1 |
| McMahon, PM | 1 |
| Araki, SS | 1 |
| Neumann, PJ | 1 |
| Harris, GJ | 1 |
| Gazelle, GS | 1 |
| Gotti, R | 1 |
| Cavrini, V | 1 |
| Pomponio, R | 1 |
| Andrisano, V | 1 |
| Werber, AE | 1 |
| Klein, C | 1 |
| Rabey, JM | 1 |
| Reeves, RR | 1 |
| Struve, FA | 1 |
| Patrick, G | 1 |
1 review available for donepezil and Sensitivity and Specificity
| Article | Year |
|---|---|
Dementia: finding the signals in the noise.
Topics: Alzheimer Disease; Dementia; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Magnetic Reson | 2005 |
7 trials available for donepezil and Sensitivity and Specificity
| Article | Year |
|---|---|
A rapid and specific approach for direct measurement of donepezil concentration in human plasma by LC-MS/MS employing solid-phase extraction.
Topics: Adult; Anticoagulants; Cholinesterase Inhibitors; Chromatography, Liquid; Citalopram; Donepezil; Dru | 2009 |
Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Cross-Over Studi | 2009 |
The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Cerebral Arteries; Cerebral Cortex; Cereb | 2010 |
Acetylcholine muscarinic receptors and response to anti-cholinesterase therapy in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhib | 2003 |
A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Metho | 2003 |
Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion.
Topics: Aged; Alzheimer Disease; Brain; Cerebrovascular Circulation; Donepezil; Female; Humans; Indans; Male | 2008 |
The effects of donepezil on quantitative EEG in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Human | 2002 |
19 other studies available for donepezil and Sensitivity and Specificity
| Article | Year |
|---|---|
1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Donepezil; | 2018 |
Development of bioanalytical HPLC method for simultaneous determination of the antialzhiemer, donepezil hydrochloride and the antidepressant, citalopram hydrobromide in raw materials, spiked human plasma and tablets dosage form.
Topics: Alzheimer Disease; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; C | 2019 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepez | 2016 |
Sensitive analysis of donepezil in plasma by capillary electrophoresis combining on-column field-amplified sample stacking and its application in Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Middle Aged; Nootro | 2008 |
Quantitation of donepezil and its active metabolite 6-O-desmethyl donepezil in human plasma by a selective and sensitive liquid chromatography-tandem mass spectrometric method.
Topics: Adult; Chromatography, Liquid; Donepezil; Fasting; Humans; Indans; Linear Models; Male; Piperidines; | 2008 |
Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Disease Progression; Donepezil; | 2009 |
A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-o-desmethyl donepezil in human plasma and its pharmacokinetic application.
Topics: Chromatography, Liquid; Donepezil; Drug Stability; Humans; Indans; Male; Piperidines; Regression Ana | 2011 |
Development and validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF).
Topics: Acetylcholine; Animals; Benzofurans; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid | 2011 |
Implementation of a cost-effective HPLC/UV-approach for medical routine quantification of donepezil in human serum.
Topics: Chromatography, High Pressure Liquid; Dementia; Donepezil; Drug Monitoring; Drug Stability; Humans; | 2012 |
Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Cognition; Di | 2005 |
Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Male; P | 2006 |
Reduction of carry-over in column-switching HPLC/MS system with automated system washing procedure for highly sensitive direct analysis of donepezil in dog plasma.
Topics: Animals; Autoanalysis; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dogs; Donepe | 2007 |
Stability indicating methods for determination of Donepezil Hydrochloride according to ICH guidelines.
Topics: Donepezil; Drug Stability; Guidelines as Topic; Indans; International Cooperation; Molecular Structu | 2006 |
Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Administration, Oral; Blood Chemical Analysis; Chromatography, Liquid; Computer Simulation; Donepezi | 2006 |
Characteristics of object location memory in mice: Behavioral and pharmacological studies.
Topics: Age Factors; Analysis of Variance; Animals; Association Learning; Behavioral Research; Cholinesteras | 2007 |
The cost-effectiveness of donepezil therapy in Swedish patients with Alzheimer's disease: a Markov model.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Data Collection; Donepezil; Humans; Indans; Marko | 1999 |
Cost-effectiveness of functional imaging tests in the diagnosis of Alzheimer disease.
Topics: Alzheimer Disease; Contrast Media; Cost-Benefit Analysis; Decision Trees; Donepezil; Health Care Cos | 2000 |
Analysis and enantioresolution of donepezil by capillary electrophoresis.
Topics: Cholinesterase Inhibitors; Donepezil; Electrophoresis, Capillary; Indans; Piperidines; Reproducibili | 2001 |
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Carbamates; Cholinesterase Inhibit | 2001 |