donepezil has been researched along with Reperfusion Injury in 5 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the effects of donepezil hydrochloride (DH) on the expression of the calpain I-cyclin-dependent kinase5/p25 (CDK5/p25) pathway in the hippocampal CA1 region in mice with cerebral ischemia-reperfusion (I/R)." | 7.80 | Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice. ( Fan, M; Jin, W; Lang, J; Lv, P; Wang, T; Zhang, H, 2014) |
| "The aim of this study was to investigate the effects of donepezil hydrochloride (DH) on the expression of the calpain I-cyclin-dependent kinase5/p25 (CDK5/p25) pathway in the hippocampal CA1 region in mice with cerebral ischemia-reperfusion (I/R)." | 3.80 | Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice. ( Fan, M; Jin, W; Lang, J; Lv, P; Wang, T; Zhang, H, 2014) |
| "Donepezil plays a neuroprotective role in I/R‑associated diseases." | 1.72 | Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling. ( Li, Y; Sun, X; Wang, J; Yang, C; Zhuang, J, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Sun, X | 1 |
| Zhuang, J | 1 |
| Wang, J | 1 |
| Yang, C | 1 |
| Yuan, X | 1 |
| Teng, X | 1 |
| Wang, Y | 1 |
| Yao, Y | 1 |
| Wang, T | 1 |
| Lv, P | 1 |
| Jin, W | 1 |
| Zhang, H | 1 |
| Lang, J | 1 |
| Fan, M | 1 |
| Sakamoto, K | 1 |
| Ohki, K | 1 |
| Saito, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Higgins, GA | 1 |
| Enderlin, M | 1 |
| Fimbel, R | 1 |
| Haman, M | 1 |
| Grottick, AJ | 1 |
| Soriano, M | 1 |
| Richards, JG | 1 |
| Kemp, JA | 1 |
| Gill, R | 1 |
5 other studies available for donepezil and Reperfusion Injury
| Article | Year |
|---|---|
Donepezil ameliorates oxygen‑glucose deprivation/reoxygenation‑induced cardiac microvascular endothelial cell dysfunction through PARP1/NF‑κB signaling.
Topics: Adolescent; Adult; Apoptosis; Cell Line; Cell Survival; Donepezil; Endothelial Cells; Female; Glucos | 2022 |
Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury.
Topics: Animals; Cholinesterase Inhibitors; Cytokines; Donepezil; Graft Survival; Heart Transplantation; Mal | 2018 |
Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice.
Topics: Animals; Brain Ischemia; Donepezil; Hippocampus; Humans; Indans; Malondialdehyde; Memory; Mice; Neur | 2014 |
Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina.
Topics: Animals; Donepezil; Indans; Male; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; R | 2010 |
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.
Topics: Alzheimer Disease; Animals; Brain Infarction; Brain Ischemia; Cell Death; Cholinesterase Inhibitors; | 2002 |