donepezil has been researched along with Protein Aggregation, Pathological in 13 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of AD-35 on cognitive impairments and neuroinflammatory changes caused by intracerebroventricular injection of Aβ25-35 were studied in rats." | 1.46 | Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease. ( Cai, J; Feng, N; Feng, R; Gong, Y; Li, J; Li, L; Liu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Zhao, X, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 4 (30.77) | 2.80 |
| Authors | Studies |
|---|---|
| Guzior, N | 1 |
| Bajda, M | 2 |
| Skrok, M | 1 |
| Kurpiewska, K | 1 |
| Lewiński, K | 1 |
| Brus, B | 1 |
| Pišlar, A | 1 |
| Kos, J | 1 |
| Gobec, S | 2 |
| Malawska, B | 2 |
| Li, Y | 3 |
| Qiang, X | 2 |
| Yang, X | 1 |
| Luo, L | 2 |
| Xiao, G | 1 |
| Cao, Z | 2 |
| Tan, Z | 2 |
| Deng, Y | 2 |
| Panek, D | 1 |
| Więckowska, A | 1 |
| Wichur, T | 1 |
| Godyń, J | 1 |
| Jończyk, J | 1 |
| Mika, K | 1 |
| Janockova, J | 1 |
| Soukup, O | 2 |
| Knez, D | 1 |
| Korabecny, J | 2 |
| Mishra, CB | 1 |
| Kumari, S | 1 |
| Manral, A | 1 |
| Prakash, A | 1 |
| Saini, V | 1 |
| Lynn, AM | 1 |
| Tiwari, M | 1 |
| Joubert, J | 1 |
| Foka, GB | 1 |
| Repsold, BP | 1 |
| Oliver, DW | 1 |
| Kapp, E | 1 |
| Malan, SF | 1 |
| Sharma, P | 1 |
| Tripathi, A | 1 |
| Tripathi, PN | 1 |
| Prajapati, SK | 1 |
| Seth, A | 1 |
| Tripathi, MK | 1 |
| Srivastava, P | 1 |
| Tiwari, V | 1 |
| Krishnamurthy, S | 1 |
| Shrivastava, SK | 1 |
| Song, Q | 1 |
| Singh, A | 1 |
| Sharma, S | 1 |
| Arora, S | 1 |
| Attri, S | 1 |
| Kaur, P | 1 |
| Kaur Gulati, H | 1 |
| Bhagat, K | 1 |
| Kumar, N | 1 |
| Singh, H | 1 |
| Vir Singh, J | 1 |
| Mohinder Singh Bedi, P | 1 |
| Du, H | 1 |
| Jiang, X | 1 |
| Ma, M | 1 |
| Xu, H | 1 |
| Liu, S | 1 |
| Ma, F | 1 |
| Chowdhury, SR | 1 |
| Gu, J | 1 |
| Hu, Y | 1 |
| Wang, J | 1 |
| Lei, S | 1 |
| Tavallaie, MS | 1 |
| Lam, C | 1 |
| Lu, D | 1 |
| Jiang, F | 1 |
| Fu, L | 1 |
| Cai, P | 1 |
| Fang, SQ | 1 |
| Yang, XL | 1 |
| Wu, JJ | 1 |
| Liu, QH | 1 |
| Hong, H | 1 |
| Wang, XB | 1 |
| Kong, LY | 1 |
| Mezeiova, E | 1 |
| Chalupova, K | 1 |
| Nepovimova, E | 1 |
| Gorecki, L | 1 |
| Prchal, L | 1 |
| Malinak, D | 1 |
| Kuca, K | 1 |
| Li, L | 1 |
| Xu, S | 1 |
| Liu, L | 1 |
| Feng, R | 1 |
| Gong, Y | 1 |
| Zhao, X | 1 |
| Li, J | 1 |
| Cai, J | 1 |
| Feng, N | 1 |
| Wang, L | 1 |
| Wang, X | 1 |
| Peng, Y | 1 |
1 review available for donepezil and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; | 2019 |
12 other studies available for donepezil and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and β-amyloid aggregation inhibitors with neuroprotective properties.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzylamines; Cell Line, Tumor; Cholinesterase Inhibito | 2015 |
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-β-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Butyrylcholinesterase; Choline | 2016 |
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Topics: Amines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Blood-Brain Barr | 2017 |
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Cell Line; Donepezil; Drug Delivery Systems; Drug Design; Humans; | 2017 |
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzyl Compounds; Binding Sites; Cholinesterase I | 2017 |
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Bloo | 2019 |
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amyloid beta-Peptides; Animals; Butyrylcholinestera | 2020 |
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cholinesterase Inh | 2020 |
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Carbolines; Cell Line; Ch | 2020 |
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Cholinesterase Inhibito | 2021 |
Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cen | 2017 |
Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Line, Tumor; Cholinestera | 2017 |