donepezil has been researched along with Peripheral Nervous System Diseases in 5 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Peripheral Nervous System Diseases: Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Single, parenteral dosing of donepezil (1, 1." | 1.36 | Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. ( Andersen, LM; Bjerrum, OJ; Folkesson, A; Honoré, PH; Kristensen, P, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selvy, M | 1 |
| Mattévi, C | 1 |
| Dalbos, C | 1 |
| Aissouni, Y | 1 |
| Chapuy, E | 1 |
| Martin, PY | 1 |
| Collin, A | 1 |
| Richard, D | 1 |
| Dumontet, C | 1 |
| Busserolles, J | 1 |
| Condé, S | 1 |
| Balayssac, D | 2 |
| Kerckhove, N | 1 |
| Tougeron, D | 1 |
| Lepage, C | 1 |
| Pezet, D | 1 |
| Le Malicot, K | 1 |
| Pelkowski, M | 1 |
| Pereira, B | 1 |
| Kawashiri, T | 1 |
| Shimizu, S | 1 |
| Shigematsu, N | 1 |
| Kobayashi, D | 1 |
| Shimazoe, T | 1 |
| Hayashida, K | 1 |
| Eisenach, JC | 1 |
| Folkesson, A | 1 |
| Honoré, PH | 1 |
| Andersen, LM | 1 |
| Kristensen, P | 1 |
| Bjerrum, OJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Donepezil in the Treatment of Oxaliplatin-induced Peripheral Neuropathy: Proof of Concept Study[NCT05254639] | Phase 2 | 80 participants (Anticipated) | Interventional | 2022-06-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for donepezil and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial.
Topics: Clinical Trials, Phase III as Topic; Donepezil; Humans; Multicenter Studies as Topic; Oxaliplatin; P | 2022 |
4 other studies available for donepezil and Peripheral Nervous System Diseases
| Article | Year |
|---|---|
Analgesic and preventive effects of donepezil in animal models of chemotherapy-induced peripheral neuropathy: Involvement of spinal muscarinic acetylcholine M2 receptors.
Topics: Acetylcholine; Analgesics; Animals; Antineoplastic Agents; Cholinesterase Inhibitors; Donepezil; Leu | 2022 |
Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Donepezil; Male; Mice; Neuroprotective Agents; Oxa | 2019 |
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Dru | 2008 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |