donepezil has been researched along with Obesity in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we tested the hypothesis that donepezil would attenuate central inflammation and oxidative damage and improve memory deficit in high-fat diet (HFD)-fed mice." | 7.91 | Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet. ( Chen, J; Fu, X; Jiang, L; Ren, H; Su, L; Wang, C; Wang, Y, 2019) |
| "Obesity is characterized by chronic inflammation of low grade." | 5.56 | Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity. ( Cargnin-Cavalho, A; Costa, AB; da Rosa Turatti, C; de Farias, BX; de Souza Goldim, MP; Engel, NA; Fortunato, JJ; Jeremias, IC; Petronilho, F; Rezin, GT, 2020) |
| "In this study, we tested the hypothesis that donepezil would attenuate central inflammation and oxidative damage and improve memory deficit in high-fat diet (HFD)-fed mice." | 3.91 | Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet. ( Chen, J; Fu, X; Jiang, L; Ren, H; Su, L; Wang, C; Wang, Y, 2019) |
| "Obesity is characterized by chronic inflammation of low grade." | 1.56 | Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity. ( Cargnin-Cavalho, A; Costa, AB; da Rosa Turatti, C; de Farias, BX; de Souza Goldim, MP; Engel, NA; Fortunato, JJ; Jeremias, IC; Petronilho, F; Rezin, GT, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, L | 1 |
| Wang, Y | 1 |
| Su, L | 1 |
| Ren, H | 1 |
| Wang, C | 1 |
| Chen, J | 1 |
| Fu, X | 1 |
| de Farias, BX | 1 |
| Costa, AB | 1 |
| Engel, NA | 1 |
| de Souza Goldim, MP | 1 |
| da Rosa Turatti, C | 1 |
| Cargnin-Cavalho, A | 1 |
| Fortunato, JJ | 1 |
| Petronilho, F | 1 |
| Jeremias, IC | 1 |
| Rezin, GT | 1 |
| Dasuri, K | 1 |
| Zhang, L | 1 |
| Kim, SO | 1 |
| Bruce-Keller, AJ | 1 |
| Keller, JN | 1 |
3 other studies available for donepezil and Obesity
| Article | Year |
|---|---|
Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet.
Topics: Animals; Diet, High-Fat; Donepezil; Glycation End Products, Advanced; Inflammation; Insulin Resistan | 2019 |
Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity.
Topics: Animals; Anti-Obesity Agents; Body Weight; Brain; Diet, High-Fat; Donepezil; Electron Transport Comp | 2020 |
Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Diet, High-Fat; Donepezil; Inflammation; Male; Mice, Inbr | 2016 |