donepezil has been researched along with Neurodegenerative Diseases in 19 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was synthesized and evaluated as multifunctional ligands against neurodegenerative diseases." | 7.96 | Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. ( Damasio, CM; Dardenne, LE; de Azevedo, LL; Guedes, IA; Kümmerle, AE; Nadur, NF; Ortiz, CJC; Pruccoli, L; Tarozzi, A; Viegas, C, 2020) |
| "A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was synthesized and evaluated as multifunctional ligands against neurodegenerative diseases." | 3.96 | Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases. ( Damasio, CM; Dardenne, LE; de Azevedo, LL; Guedes, IA; Kümmerle, AE; Nadur, NF; Ortiz, CJC; Pruccoli, L; Tarozzi, A; Viegas, C, 2020) |
| "Donepezil 10 mg/day was begun." | 1.33 | Improvement in Tc-99m HMPAO brain SPECT findings during donepezil therapy in a patient with pure akinesia. ( Akdal, G; Kaya, GC; Oztürk, V; Yener, GG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 7 (36.84) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalli, A | 1 |
| Bolognesi, ML | 1 |
| Minarini, A | 1 |
| Rosini, M | 1 |
| Tumiatti, V | 1 |
| Recanatini, M | 1 |
| Melchiorre, C | 1 |
| Rui, M | 1 |
| Rossino, G | 1 |
| Coniglio, S | 1 |
| Monteleone, S | 1 |
| Scuteri, A | 1 |
| Malacrida, A | 1 |
| Rossi, D | 1 |
| Catenacci, L | 1 |
| Sorrenti, M | 1 |
| Paolillo, M | 1 |
| Curti, D | 1 |
| Venturini, L | 1 |
| Schepmann, D | 1 |
| Wünsch, B | 1 |
| Liedl, KR | 1 |
| Cavaletti, G | 1 |
| Pace, V | 1 |
| Urban, E | 1 |
| Collina, S | 1 |
| Venkanna, A | 1 |
| Cho, KH | 1 |
| Dhorma, LP | 1 |
| Kumar, DN | 1 |
| Hah, JM | 1 |
| Park, HG | 1 |
| Kim, SY | 1 |
| Kim, MH | 1 |
| Gabr, M | 1 |
| Murugan, NA | 1 |
| Fantacuzzi, M | 1 |
| Amoroso, R | 1 |
| Carradori, S | 1 |
| De Filippis, B | 1 |
| Haji Ali, S | 1 |
| Osmaniye, D | 1 |
| Sağlık, BN | 1 |
| Levent, S | 1 |
| Özkay, Y | 1 |
| Kaplancıklı, ZA | 1 |
| Majidazar, R | 1 |
| Rezazadeh-Gavgani, E | 1 |
| Sadigh-Eteghad, S | 1 |
| Naseri, A | 1 |
| Kapoor, T | 1 |
| Mehan, S | 1 |
| Suri, M | 1 |
| Sharma, N | 1 |
| Kumar, N | 1 |
| Narula, AS | 1 |
| Alshammari, A | 1 |
| Alasmari, AF | 1 |
| Alharbi, M | 1 |
| Assiri, MA | 1 |
| Kalfin, R | 1 |
| Moreira, NCDS | 2 |
| Tamarozzi, ER | 2 |
| Lima, JEBF | 2 |
| Piassi, LO | 2 |
| Carvalho, I | 2 |
| Passos, GA | 2 |
| Sakamoto-Hojo, ET | 2 |
| Ortiz, CJC | 1 |
| Damasio, CM | 1 |
| Pruccoli, L | 1 |
| Nadur, NF | 1 |
| de Azevedo, LL | 1 |
| Guedes, IA | 1 |
| Dardenne, LE | 1 |
| Kümmerle, AE | 1 |
| Tarozzi, A | 1 |
| Viegas, C | 1 |
| Yoshiyama, Y | 1 |
| Kawahira, K | 1 |
| Noma, T | 1 |
| Iiyama, J | 1 |
| Etoh, S | 1 |
| Ogata, A | 1 |
| Shimodozono, M | 1 |
| Sakamoto, K | 1 |
| Ohki, K | 1 |
| Saito, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Iliffe, S | 1 |
| McGrath, T | 1 |
| Mitchell, D | 1 |
| Lo, D | 1 |
| Grossberg, GT | 1 |
| Weiner, DM | 1 |
| Goodman, MW | 1 |
| Colpitts, TM | 1 |
| Feddock, MA | 1 |
| Duggento, KL | 1 |
| Nash, NR | 1 |
| Levey, AI | 1 |
| Brann, MR | 1 |
| Yener, GG | 1 |
| Kaya, GC | 1 |
| Oztürk, V | 1 |
| Akdal, G | 1 |
| Ringman, JM | 1 |
| Cummings, JL | 1 |
| Fukunaga, K | 1 |
| Shioda, N | 1 |
| Morioka, M | 1 |
| Han, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Cohort Study of Single Agent Memantine in Patients With Child-Pugh Score ≥ B7 Cirrhosis and Hepatocellular Carcinoma[NCT06007846] | Phase 2/Phase 3 | 12 participants (Anticipated) | Interventional | 2023-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for donepezil and Neurodegenerative Diseases
| Article | Year |
|---|---|
Multi-target-directed ligands to combat neurodegenerative diseases.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium | 2008 |
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy.
Topics: Humans; Neurodegenerative Diseases; Polyphenols; Resveratrol; Stilbenes; Structure-Activity Relation | 2022 |
Pharmacotherapy of Alzheimer's disease: an overview of systematic reviews.
Topics: Alzheimer Disease; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti- | 2022 |
[Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse].
Topics: Acetylcholine; Amyloid; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil | 2008 |
Use of memantine for the treatment of dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Dopamine Agents; Humans; Indans; | 2011 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Human | 2006 |
[Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders].
Topics: Animals; Cognition; Donepezil; Drug Design; Extracellular Signal-Regulated MAP Kinases; Hippocampus; | 2008 |
12 other studies available for donepezil and Neurodegenerative Diseases
| Article | Year |
|---|---|
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhi | 2018 |
Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone.
Topics: Drug Discovery; Inflammation; Microglia; Neurodegenerative Diseases; Neuroprotective Agents; Nitric | 2019 |
Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands.
Topics: Acetylcholinesterase; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinest | 2020 |
Design, Synthesis, and Evaluation of Novel 2
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Donepezil | 2022 |
Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cytokines; Demyelinating Diseases; Donepezil; Ethidium; Fingo | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cinnamates | 2020 |
Improvements in limb kinetic apraxia by repetition of a newly designed facilitation exercise in a patient with corticobasal degeneration.
Topics: Activities of Daily Living; Apraxia, Ideomotor; Cholinesterase Inhibitors; Disease Progression; Done | 2009 |
Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina.
Topics: Animals; Donepezil; Indans; Male; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; R | 2010 |
The impact of patient and public involvement in the work of the Dementias & Neurodegenerative Diseases Research Network (DeNDRoN): case studies.
Topics: Alzheimer Disease; Biomedical Research; Community Participation; Dementia; Donepezil; Humans; Indans | 2013 |
Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias.
Topics: Aged; Cholinesterase Inhibitors; Cohort Studies; Dementia; DNA; Donepezil; Drug Delivery Systems; Fe | 2004 |
Improvement in Tc-99m HMPAO brain SPECT findings during donepezil therapy in a patient with pure akinesia.
Topics: Alexia, Pure; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Gait Disorders, Neurologic; Ind | 2005 |