donepezil has been researched along with Neuroblastoma in 21 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, a Drosophila AD model and SH-SY5Y clles were used to assess the toxicity of SIP3, and APPswe/PS1dE9 (APP/PS1) transgenic mice were used to evaluate the cognitive-behavioral and depression-like behavior effect of SIP3 and donepezil co-treatment on symptoms of AD." | 8.12 | Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease. ( Chin, YW; Choi, H; Kanmani, S; Kim, KK; Kim, KW; Kim, SN; Kim, YM; Koo, BS; Liu, QF; Son, T, 2022) |
| " We have studied the neuroprotective effects of these drugs, in comparison with nicotine, on cell death caused by beta-amyloid (Abeta) and okadaic acid, two models that are relevant to Alzheimer's pathology, in the human neuroblastoma cell line SH-SY5Y." | 7.73 | Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. ( Arias, E; Gallego-Sandín, S; García, AG; López, MG; Villarroya, M, 2005) |
| "In this study, a Drosophila AD model and SH-SY5Y clles were used to assess the toxicity of SIP3, and APPswe/PS1dE9 (APP/PS1) transgenic mice were used to evaluate the cognitive-behavioral and depression-like behavior effect of SIP3 and donepezil co-treatment on symptoms of AD." | 4.12 | Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease. ( Chin, YW; Choi, H; Kanmani, S; Kim, KK; Kim, KW; Kim, SN; Kim, YM; Koo, BS; Liu, QF; Son, T, 2022) |
| " It was reported recently that nicotine may have protective effects against salsolinol-induced toxicity in human neuroblastoma derived SH-SY5Y cells and that these effects of nicotine are mediated by nicotinic receptors." | 3.75 | Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. ( Das, JR; Tizabi, Y, 2009) |
| " We have studied the neuroprotective effects of these drugs, in comparison with nicotine, on cell death caused by beta-amyloid (Abeta) and okadaic acid, two models that are relevant to Alzheimer's pathology, in the human neuroblastoma cell line SH-SY5Y." | 3.73 | Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. ( Arias, E; Gallego-Sandín, S; García, AG; López, MG; Villarroya, M, 2005) |
| " Here, we investigate the mechanisms of action of the AChEI donepezil on APP (amyloid precursor protein) metabolism and on the activity/trafficking of the alpha-secretase candidate ADAM 10, in differentiated human neuroblastoma cells (SH-SY5Y)." | 3.72 | Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines. ( Borroni, B; Cattabeni, F; Colciaghi, F; Di Luca, M; Gardoni, F; Marcello, E; Padovani, A; Zimmermann, M, 2004) |
| " In silico predicted ADME and physicochemical properties of conjugates showed good CNS bioavailability and safety parameters." | 2.44 | Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies. ( Abd El-Wahab, HAA; Akincioglu, H; Gülçin, İ; Omar, FA; Soliman, AM, 2024) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 12 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, XT | 1 |
| Wang, CM | 1 |
| Liu, Y | 1 |
| Huang, ZG | 1 |
| Malek, R | 1 |
| Arribas, RL | 1 |
| Palomino-Antolin, A | 1 |
| Totoson, P | 1 |
| Demougeot, C | 1 |
| Kobrlova, T | 1 |
| Soukup, O | 1 |
| Iriepa, I | 1 |
| Moraleda, I | 1 |
| Diez-Iriepa, D | 1 |
| Godyń, J | 1 |
| Panek, D | 1 |
| Malawska, B | 1 |
| Głuch-Lutwin, M | 1 |
| Mordyl, B | 1 |
| Siwek, A | 1 |
| Chabchoub, F | 1 |
| Marco-Contelles, J | 1 |
| Kiec-Kononowicz, K | 1 |
| Egea, J | 1 |
| de Los Ríos, C | 1 |
| Ismaili, L | 1 |
| Rodríguez-Lavado, J | 1 |
| Gallardo-Garrido, C | 1 |
| Mallea, M | 1 |
| Bustos, V | 1 |
| Osorio, R | 1 |
| Hödar-Salazar, M | 1 |
| Chung, H | 1 |
| Araya-Maturana, R | 1 |
| Lorca, M | 1 |
| Pessoa-Mahana, CD | 1 |
| Mella-Raipán, J | 1 |
| Saitz, C | 1 |
| Jaque, P | 1 |
| Reyes-Parada, M | 1 |
| Iturriaga-Vásquez, P | 1 |
| Pessoa-Mahana, H | 1 |
| Macedo Vaz, S | 1 |
| de Freitas Silva, M | 1 |
| Dos Reis Rosa Franco, G | 1 |
| Jorge R Guimarães, M | 1 |
| Motta R da Silva, F | 1 |
| Gonçalves Castro, N | 1 |
| Alvim Guedes, I | 1 |
| Dardenne, LE | 1 |
| Amaral Alves, M | 1 |
| Garrett da Costa, R | 1 |
| Beserra Pinheiro, G | 1 |
| Germino Veras, L | 1 |
| Renata Mortari, M | 1 |
| Pruccoli, L | 1 |
| Tarozzi, A | 1 |
| Viegas, C | 1 |
| Liu, QF | 2 |
| Choi, H | 1 |
| Son, T | 1 |
| Kim, YM | 1 |
| Kanmani, S | 1 |
| Chin, YW | 1 |
| Kim, SN | 1 |
| Kim, KK | 2 |
| Kim, KW | 1 |
| Koo, BS | 2 |
| Liu, DF | 1 |
| Bai, M | 1 |
| Du, NN | 1 |
| Shen, S | 1 |
| Li, ZY | 1 |
| Zhang, X | 1 |
| Guo, R | 1 |
| Yao, GD | 1 |
| Song, SJ | 1 |
| Huang, XX | 1 |
| Wiatrak, B | 1 |
| Krzyżak, E | 1 |
| Szczęśniak-Sięga, B | 1 |
| Szandruk-Bender, M | 1 |
| Szeląg, A | 1 |
| Nowak, B | 1 |
| Moreira, NCDS | 2 |
| Tamarozzi, ER | 2 |
| Lima, JEBF | 2 |
| Piassi, LO | 2 |
| Carvalho, I | 2 |
| Passos, GA | 2 |
| Sakamoto-Hojo, ET | 2 |
| Girgin, M | 1 |
| Isik, S | 1 |
| Kantarci-Carsibasi, N | 1 |
| Kiran, PVR | 1 |
| Waiker, DK | 1 |
| Verma, A | 1 |
| Saraf, P | 1 |
| Bhardwaj, B | 1 |
| Kumar, H | 1 |
| Singh, A | 1 |
| Kumar, P | 1 |
| Singh, N | 1 |
| Srikrishna, S | 1 |
| Trigun, SK | 1 |
| Shrivastava, SK | 1 |
| Maiuolo, J | 1 |
| Costanzo, P | 1 |
| Masullo, M | 1 |
| D'Errico, A | 1 |
| Nasso, R | 1 |
| Bonacci, S | 1 |
| Mollace, V | 1 |
| Oliverio, M | 1 |
| Arcone, R | 1 |
| Soliman, AM | 1 |
| Abd El-Wahab, HAA | 1 |
| Akincioglu, H | 1 |
| Gülçin, İ | 1 |
| Omar, FA | 1 |
| Kim, JS | 1 |
| Kim, MG | 1 |
| Ryu, JE | 1 |
| Lee, YB | 1 |
| Cho, SH | 1 |
| Shin, SJ | 1 |
| Choi, HK | 1 |
| Damuka, N | 1 |
| Kammari, K | 1 |
| Potshangbam, AM | 1 |
| Rathore, RS | 1 |
| Kondapi, AK | 1 |
| Vindal, V | 1 |
| Prasad, S | 1 |
| Kumar, B | 1 |
| Kumar, S | 1 |
| Chand, K | 1 |
| Kamble, SS | 1 |
| Gautam, HK | 1 |
| Sharma, SK | 1 |
| Getachew, B | 1 |
| Hudson, T | 1 |
| Heinbockel, T | 1 |
| Csoka, AB | 1 |
| Tizabi, Y | 2 |
| Das, JR | 1 |
| Hwang, SH | 1 |
| Shin, EJ | 1 |
| Shin, TJ | 1 |
| Lee, BH | 1 |
| Choi, SH | 1 |
| Kang, J | 1 |
| Kim, HJ | 1 |
| Kwon, SH | 1 |
| Jang, CG | 1 |
| Lee, JH | 1 |
| Kim, HC | 1 |
| Nah, SY | 1 |
| Zhang, BF | 1 |
| Peng, FF | 1 |
| Zhang, JZ | 1 |
| Wu, DC | 1 |
| Zimmermann, M | 1 |
| Gardoni, F | 1 |
| Marcello, E | 1 |
| Colciaghi, F | 1 |
| Borroni, B | 1 |
| Padovani, A | 1 |
| Cattabeni, F | 1 |
| Di Luca, M | 1 |
| Arias, E | 1 |
| Gallego-Sandín, S | 1 |
| Villarroya, M | 1 |
| García, AG | 1 |
| López, MG | 1 |
21 other studies available for donepezil and Neuroblastoma
| Article | Year |
|---|---|
New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Dose- | 2015 |
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Cholinesterase Inhibitors; Humans; Memory Diso | 2019 |
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antidepressive Agents; Cell | 2020 |
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cholinesterase Inhibit | 2022 |
Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Depression; Diseas | 2022 |
Insight into Isolation and Characterization of Phenolic Compounds from Hawthorn (Crataegus pinnatifida Bge.) with Antioxidant, Anti-Acetylcholinesterase, and Neuroprotective Activities.
Topics: Acetylcholinesterase; Antioxidants; Crataegus; Donepezil; Ethanol; Humans; Hydrogen Peroxide; Molecu | 2022 |
Effect of tricyclic 1,2-thiazine derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Coculture Techniques; Donepezil; Humans; Inflammation; | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Novel Dual AChE and ROCK2 Inhibitor Induces Neurogenesis via PTEN/AKT Pathway in Alzheimer's Disease Model.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Neuroblastoma | 2022 |
Proposing novel natural compounds against Alzheimer's disease targeting acetylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; | 2023 |
Design and development of benzyl piperazine linked 5-phenyl-1,2,4-triazole-3-thione conjugates as potential agents to combat Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; | 2023 |
Hydroxytyrosol-Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer's Disease Model and in Neuronal Differentiated Human SH-SY5Y Neuroblastoma Cells.
Topics: Alzheimer Disease; Antioxidants; Donepezil; Humans; Neuroblastoma; tau Proteins | 2023 |
Piperazine-2-carboxylic acid derivatives as MTDLs anti-Alzheimer agents: Anticholinesterase activity, mechanistic aspect, and molecular modeling studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Carboxylic Acids; Cholinest | 2024 |
Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Donepezil; Humans; Metabolome; Methion | 2024 |
Discovery of dual cation-π inhibitors of acetylcholinesterase: design, synthesis and biological evaluation.
Topics: Acetylcholinesterase; Binding Sites; Cations; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibi | 2020 |
Acetamide Derivatives of Chromen-2-ones as Potent Cholinesterase Inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2017 |
Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3.
Topics: Caspase 3; Cell Line, Tumor; Central Nervous System Depressants; Donepezil; Dose-Response Relationsh | 2018 |
Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells.
Topics: Analysis of Variance; Annexin A5; Apoptosis; Atropine; Cell Cycle; Cell Line, Tumor; Cell Survival; | 2009 |
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2012 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; | 2002 |
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.
Topics: Acetylcholinesterase; ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Pre | 2004 |
Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Apoptosis; Benzopyrans; Cell Culture Techniques; Cell Line, Tumor; | 2005 |