donepezil has been researched along with Nerve Pain in 7 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil was started at 3-5 mg/day upon experiencing gabapentinoid-induced somnolence." | 1.46 | Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review. ( Abe, H; Hozumi, J; Ikegami, K; Inoue, R; Kawahara, K; Kogure, T; Sumitani, M; Yamada, Y, 2017) |
| "Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy has been really effective for its treatment." | 1.42 | Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception. ( Aissouni, Y; Balayssac, D; Bayet-Robert, M; Chalus, M; Dalmann, R; Daulhac, L; El Guerrab, A; Eschalier, A; Ferrier, J; Graveron-Demilly, D; Marchand, F; Pinguet, J; Richard, D, 2015) |
| " Single, parenteral dosing of donepezil (1, 1." | 1.36 | Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. ( Andersen, LM; Bjerrum, OJ; Folkesson, A; Honoré, PH; Kristensen, P, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Basnet, A | 1 |
| Butler, S | 1 |
| Honoré, PH | 2 |
| Butler, M | 1 |
| Gordh, TE | 1 |
| Kristensen, K | 1 |
| Bjerrum, OJ | 3 |
| Bjerrum, HJ | 1 |
| Ferrier, J | 1 |
| Bayet-Robert, M | 1 |
| Dalmann, R | 1 |
| El Guerrab, A | 1 |
| Aissouni, Y | 1 |
| Graveron-Demilly, D | 1 |
| Chalus, M | 1 |
| Pinguet, J | 1 |
| Eschalier, A | 1 |
| Richard, D | 1 |
| Daulhac, L | 1 |
| Marchand, F | 1 |
| Balayssac, D | 1 |
| Kogure, T | 1 |
| Sumitani, M | 1 |
| Ikegami, K | 1 |
| Abe, H | 1 |
| Hozumi, J | 1 |
| Inoue, R | 1 |
| Kawahara, K | 1 |
| Yamada, Y | 1 |
| Folkesson, A | 1 |
| Andersen, LM | 1 |
| Kristensen, P | 1 |
| Kimura, M | 1 |
| Hayashida, K | 2 |
| Eisenach, JC | 1 |
| Saito, S | 1 |
| Obata, H | 2 |
1 review available for donepezil and Nerve Pain
| Article | Year |
|---|---|
[Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems].
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics; Animals; Brain-Derived Neur | 2007 |
1 trial available for donepezil and Nerve Pain
| Article | Year |
|---|---|
Donepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study.
Topics: Adult; Aged; Algorithms; Amines; Analgesics; Cyclohexanecarboxylic Acids; Cyclohexanols; Donepezil; | 2014 |
5 other studies available for donepezil and Nerve Pain
| Article | Year |
|---|---|
[Donepezil therapy by neuropathic pain].
Topics: Aged; Analgesics; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Neuralgia; Piperidin | 2013 |
Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.
Topics: Analgesics; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Gene Expression; Hyperal | 2015 |
Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review.
Topics: Adult; Aged; Aged, 80 and over; Amines; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Diso | 2017 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Anima | 2013 |