Page last updated: 2024-10-26

donepezil and Nausea

donepezil has been researched along with Nausea in 14 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"Sustained-release, high-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD)."9.24Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index. ( Bae, JN; Carroll, BJ; Han, C; Jung, YE; Kang, HS; Kim, BJ; Kim, BS; Kim, DK; Kim, JL; Kim, KW; Kim, SG; Kim, SY; Kim, YH; Lee, C; Lee, DW; Lee, JY; Lee, K; Lee, SY; Lee, YM; Moon, SW; Myung, W; Ryu, SH; Shin, IS; Yu, H, 2017)
"Sustained-release, high-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD)."5.24Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index. ( Bae, JN; Carroll, BJ; Han, C; Jung, YE; Kang, HS; Kim, BJ; Kim, BS; Kim, DK; Kim, JL; Kim, KW; Kim, SG; Kim, SY; Kim, YH; Lee, C; Lee, DW; Lee, JY; Lee, K; Lee, SY; Lee, YM; Moon, SW; Myung, W; Ryu, SH; Shin, IS; Yu, H, 2017)
"Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy."4.12Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice. ( Hagihara, K; Jotaki, A; Kirikihira, K; Michihara, A; Miyake, Y; Sato, Y; Yamamoto, K, 2022)
" There were 2 cases of adverse reaction of increased stool frequency in GV-971 (5."3.11Efficacy and safety of sodium oligomannate in the treatment of Alzheimer's disease. ( Lin, PX; Xue, LH; Zhang, LF; Zhang, YP, 2022)
" Experiment 1 tested the effects of 5 mg/per day dosage on cognitive and EEG markers at 6-hour, 2-week and 4-week follow-ups."2.76Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers. ( Balsters, JH; Bokde, AL; Brennan, S; Cassidy, SM; Delmonte, S; Fagan, AJ; Galli, A; Kilcullen, SM; Lai, R; Laruelle, M; Lawlor, B; Martin, MP; Meaney, JF; O'Connell, RG; Robertson, IH; Upton, N, 2011)
" Adverse events (AEs) were recorded throughout."2.75Safety and tolerability of donepezil in mild cognitive impairment: open-label extension study. ( Doody, RS; Ferris, S; Gao, J; Goldman, R; Murthy, AK; Salloway, S, 2010)
"Donepezil-treated patients showed significant benefits in activities of daily living over placebo on the Alzheimer's Disease Functional Assessment and Change Scale (mean change from baseline score effect size at week 24: donepezil 5 mg/d, -1."2.71Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. ( Black, S; Burns, A; Geldmacher, DS; Hecker, J; Kumar, D; Perdomo, C; Pratt, R; Román, GC; Salloway, S, 2003)
"Donepezil (Aricept) is a highly selective acetylcholinesterase inhibitors with a pharmacokinetic profile allowing once-daily dosing."2.42Donepezil (Aricept) for treatment of Alzheimer's disease and other dementing conditions. ( Geldmacher, DS, 2004)
"Donepezil is a synthetic noncovalent reversible inhibitor of acetylcholinesterase (AChE) for the treatment of mild to moderate dementia associated with Alzheimer's disease."2.40Donepezil: an anticholinesterase inhibitor for Alzheimer's disease. ( Shintani, EY; Uchida, KM, 1997)
" The adverse drug effects and discontinuation rates were investigated with self-reported complaint after starting or increasing anti-dementia drugs."1.48Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia. ( Cho, AH; Kim, JS; Lim, EY; Yang, DW, 2018)
"The objective was to investigate the frequency of adverse events (AE) as a cause for discontinuation of donepezil treatment for Alzheimer's dementia (DAT) in a geriatric memory unit."1.35[Adverse events causing discontinuation of donepezil for Alzheimer's dementia]. ( Carøe, TK; Moe, C, 2009)
"Donepezil is an acetylcholinesterase inhibitor indicated for the symptomatic treatment of mild to moderate Alzheimer's disease."1.31Adverse effects associated with the use of donepezil in general practice in England. ( Dunn, NR; Pearce, GL; Shakir, SA, 2000)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's6 (42.86)29.6817
2010's5 (35.71)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Zhang, LF1
Zhang, YP1
Lin, PX1
Xue, LH1
Yamamoto, K1
Sato, Y1
Hagihara, K1
Kirikihira, K1
Jotaki, A1
Michihara, A1
Miyake, Y1
Lee, C1
Lee, K1
Yu, H1
Ryu, SH1
Moon, SW1
Han, C1
Lee, JY1
Lee, YM1
Kim, SG1
Kim, KW1
Lee, DW1
Kim, SY2
Lee, SY1
Bae, JN1
Jung, YE1
Kim, JL1
Kim, BS1
Shin, IS1
Kim, YH1
Kim, BJ1
Kang, HS1
Myung, W1
Carroll, BJ1
Kim, DK1
Lim, EY1
Yang, DW1
Kim, JS1
Cho, AH1
Han, SH1
Lee, JH1
Park, KW1
Chen, C1
Tripathi, M1
Dash, A1
Kubota, N1
Doody, RS1
Ferris, S1
Salloway, S2
Goldman, R1
Gao, J1
Murthy, AK1
Carøe, TK1
Moe, C1
Balsters, JH1
O'Connell, RG1
Martin, MP1
Galli, A1
Cassidy, SM1
Kilcullen, SM1
Delmonte, S1
Brennan, S1
Meaney, JF1
Fagan, AJ1
Bokde, AL1
Upton, N1
Lai, R1
Laruelle, M1
Lawlor, B1
Robertson, IH1
Heller, JH1
Spiridigliozzi, GA1
Sullivan, JA1
Doraiswamy, PM1
Krishnan, RR1
Kishnani, PS1
Black, S1
Román, GC1
Geldmacher, DS2
Hecker, J1
Burns, A1
Perdomo, C1
Kumar, D1
Pratt, R1
Shintani, EY1
Uchida, KM1
Dunn, NR1
Pearce, GL1
Shakir, SA1
Lam, W1

Reviews

2 reviews available for donepezil and Nausea

ArticleYear
Donepezil (Aricept) for treatment of Alzheimer's disease and other dementing conditions.
    Expert review of neurotherapeutics, 2004, Volume: 4, Issue:1

    Topics: Alzheimer Disease; Anorexia; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorder

2004
Donepezil: an anticholinesterase inhibitor for Alzheimer's disease.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Dec-15, Volume: 54, Issue:24

    Topics: Aged; Alzheimer Disease; Anorexia; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug Administrati

1997

Trials

7 trials available for donepezil and Nausea

ArticleYear
Efficacy and safety of sodium oligomannate in the treatment of Alzheimer's disease.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:3

    Topics: Alzheimer Disease; Donepezil; Humans; Ions; Nausea; Sodium

2022
Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index.
    Journal of clinical psychopharmacology, 2017, Volume: 37, Issue:4

    Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Body Mass Index; Body Weight; Chol

2017
Donepezil 23 mg in Asian patients with moderate-to-severe Alzheimer's disease.
    Acta neurologica Scandinavica, 2017, Volume: 135, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Donepezil; Dose

2017
Safety and tolerability of donepezil in mild cognitive impairment: open-label extension study.
    American journal of Alzheimer's disease and other dementias, 2010, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amnesia; Cholinesterase Inhibitors; Cognition Disorders; Diarrhea; D

2010
Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Aged; Analysis of Variance; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Diarrhea; Done

2011
Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial.
    American journal of medical genetics. Part A, 2003, Jan-15, Volume: 116A, Issue:2

    Topics: Adult; Appetite; Cholinesterase Inhibitors; Diarrhea; Donepezil; Dose-Response Relationship, Drug; D

2003
Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial.
    Stroke, 2003, Volume: 34, Issue:10

    Topics: Activities of Daily Living; Aged; Aged, 80 and over; Cardiovascular System; Cholinesterase Inhibitor

2003

Other Studies

5 other studies available for donepezil and Nausea

ArticleYear
Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice.
    Journal of pharmacological sciences, 2022, Volume: 150, Issue:2

    Topics: Acetylcholinesterase; Animals; Anorexia; Donepezil; Drugs, Chinese Herbal; Ghrelin; Humans; Kaolin;

2022
Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia.
    Journal of Korean medical science, 2018, May-07, Volume: 33, Issue:19

    Topics: Activities of Daily Living; Aged, 80 and over; Alzheimer Disease; Donepezil; Exanthema; Female; Huma

2018
[Adverse events causing discontinuation of donepezil for Alzheimer's dementia].
    Ugeskrift for laeger, 2009, Dec-07, Volume: 171, Issue:50

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Appetite; Cholinesterase Inhibitors; Diarrhea; Donepezil

2009
Adverse effects associated with the use of donepezil in general practice in England.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:4

    Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Drug Prescriptions; E

2000
Pharmacological treatment of cognitive deficits in Alzheimer's disease.
    The Medical journal of Australia, 2002, Mar-18, Volume: 176, Issue:6

    Topics: Alzheimer Disease; Diarrhea; Donepezil; Humans; Indans; Nausea; Nootropic Agents; Piperidines; Vomit

2002
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