donepezil has been researched along with Muscle Contraction in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Broad, J | 1 |
| Kung, VW | 1 |
| Boundouki, G | 1 |
| Aziz, Q | 1 |
| De Maeyer, JH | 1 |
| Knowles, CH | 1 |
| Sanger, GJ | 1 |
| Shimizu, N | 1 |
| Nakahara, T | 1 |
| Kubota, Y | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Caricati-Neto, A | 1 |
| D'angelo, LC | 1 |
| Reuter, H | 1 |
| Hyppolito Jurkiewicz, N | 1 |
| Garcia, AG | 1 |
| Jurkiewicz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of Prucalopride (R108512) Tablets in Subjects With Chronic Constipation[NCT00488137] | Phase 3 | 716 participants (Actual) | Interventional | 1998-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for donepezil and Muscle Contraction
| Article | Year |
|---|---|
Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Cholinesterase Inhibitors; Colon; Donepezil; Drug Syner | 2013 |
Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Donepezil; Indans; Indomethacin; Male; Muscle Contract | 2010 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; | 2004 |