donepezil has been researched along with Learning Disabilities in 17 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia." | 4.84 | Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature. ( Valdovinos, MG; Williams, DC; Yoo, JH, 2007) |
| "Donepezil is a potent acetylcholinesterase inhibitor that also interacts with the sigma1 receptor, an intracellular neuromodulatory protein." | 1.33 | Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. ( Ieni, J; Maurice, T; Meunier, J, 2006) |
| "Donepezil is a member of a new class of centrally acting cholinesterase inhibitors which preferentially inhibit acetylcholinesterase rather than butyrylcholinesterase." | 1.31 | Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats. ( Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Gomaa, AA | 1 |
| Makboul, RM | 1 |
| El-Mokhtar, MA | 1 |
| Abdel-Rahman, EA | 1 |
| Ahmed, EA | 1 |
| Nicola, MA | 1 |
| Meunier, J | 2 |
| Borjini, N | 1 |
| Gillis, C | 1 |
| Villard, V | 1 |
| Maurice, T | 2 |
| Shi, SH | 1 |
| Zhao, X | 1 |
| Liu, AJ | 1 |
| Liu, B | 1 |
| Li, H | 1 |
| Wu, B | 1 |
| Bi, KS | 1 |
| Jia, Y | 1 |
| Safar, MM | 1 |
| Arab, HH | 1 |
| Rizk, SM | 1 |
| El-Maraghy, SA | 1 |
| Guo, HB | 1 |
| Cheng, YF | 1 |
| Wu, JG | 1 |
| Wang, CM | 1 |
| Wang, HT | 1 |
| Zhang, C | 1 |
| Qiu, ZK | 1 |
| Xu, JP | 1 |
| Hasanein, P | 1 |
| Seifi, R | 1 |
| Hajinezhad, MR | 1 |
| Emamjomeh, A | 1 |
| Benetti, F | 1 |
| Mello, PB | 1 |
| Bonini, JS | 1 |
| Monteiro, S | 1 |
| Cammarota, M | 1 |
| Izquierdo, I | 1 |
| Masuoka, T | 1 |
| Kamei, C | 1 |
| Araujo, JA | 1 |
| Greig, NH | 1 |
| Ingram, DK | 1 |
| Sandin, J | 1 |
| de Rivera, C | 1 |
| Milgram, NW | 1 |
| Liu, Y | 1 |
| Aisa, HA | 1 |
| Ji, C | 1 |
| Yang, N | 1 |
| Zhu, H | 1 |
| Zuo, P | 1 |
| Sabbagh, JJ | 1 |
| Heaney, CF | 1 |
| Bolton, MM | 1 |
| Murtishaw, AS | 1 |
| Ure, JA | 1 |
| Kinney, JW | 1 |
| Jung, IH | 1 |
| Jang, SE | 1 |
| Joh, EH | 1 |
| Chung, J | 1 |
| Han, MJ | 1 |
| Kim, DH | 1 |
| Jia, F | 1 |
| Kato, M | 1 |
| Dai, H | 1 |
| Xu, A | 1 |
| Okuda, T | 1 |
| Sakurai, E | 1 |
| Okamura, N | 1 |
| Lovenberg, TW | 1 |
| Barbier, A | 1 |
| Carruthers, NI | 1 |
| Iinuma, K | 1 |
| Yanai, K | 1 |
| Ieni, J | 1 |
| Yoo, JH | 1 |
| Valdovinos, MG | 1 |
| Williams, DC | 1 |
| Ogura, H | 2 |
| Kosasa, T | 2 |
| Kuriya, Y | 1 |
| Yamanishi, Y | 2 |
| Araki, S | 1 |
2 reviews available for donepezil and Learning Disabilities
| Article | Year |
|---|---|
Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature.
Topics: Alzheimer Disease; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Autistic Disor | 2007 |
[Pharmacological properties of donepezil hydrochloride (Aricept), a drug for Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Clinical Trials as Topi | 2000 |
15 other studies available for donepezil and Learning Disabilities
| Article | Year |
|---|---|
Evaluation of the neuroprotective effect of donepezil in type 2 diabetic rats.
Topics: Alzheimer Disease; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Donepezil; H | 2021 |
Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.
Topics: Adenine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Age | 2015 |
Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments.
Topics: 1-Butanol; Alpinia; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Avoidance | 2015 |
Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations.
Topics: Adipose Tissue; Alzheimer Disease; Animals; Cell Movement; Cells, Cultured; Cognition Disorders; Cyt | 2016 |
Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiat | 2015 |
Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antioxidants; Avoidance Learning; Behavior, Anim | 2017 |
Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Disease Models, Animal | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, D | 2009 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhi | 2011 |
Effects of Gossypium herbaceam extract administration on the learning and memory function in the naturally aged rats: neuronal niche improvement.
Topics: Aging; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotroph | 2012 |
Administration of donepezil does not rescue galanin-induced spatial learning deficits.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Donepezil; Galanin; Indans; Learning Disabili | 2012 |
Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cholinesterase | 2012 |
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Topics: Animals; Avoidance Learning; Convulsants; Donepezil; Electric Stimulation; Female; Histamine Antagon | 2006 |
Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Carbon Monoxide; Cholinesterase Inhibitors; | 2006 |
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Re | 2000 |