donepezil has been researched along with Intellectual Disability in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A 38-year-old woman with Down syndrome, diagnosed with secondary progressive dementia when her mental state had deteriorated rapidly after graduation from junior high school, started donepezil treatment." | 7.73 | Dramatic improvement in Down syndrome-associated cognitive impairment with donepezil. ( Aikawa, K; Amamoto, N; Aoki, M; Doi, T; Hamada, H; Harada, J; Kondoh, T; Moriuchi, H; Nakashima, M; Ogawa, Y; Sasaki, H; Tanaka, T, 2005) |
| " A 38-year-old woman with Down syndrome, diagnosed with secondary progressive dementia when her mental state had deteriorated rapidly after graduation from junior high school, started donepezil treatment." | 3.73 | Dramatic improvement in Down syndrome-associated cognitive impairment with donepezil. ( Aikawa, K; Amamoto, N; Aoki, M; Doi, T; Hamada, H; Harada, J; Kondoh, T; Moriuchi, H; Nakashima, M; Ogawa, Y; Sasaki, H; Tanaka, T, 2005) |
| "Whereas Trisomy 21 is one of the most widespread genetic causes of intellectual disability (ID), it still is one of the least understood of all genetic ID syndromes." | 2.49 | Atypical aging in Down syndrome. ( Zigman, WB, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zigman, WB | 1 |
| Kondoh, T | 1 |
| Amamoto, N | 1 |
| Doi, T | 1 |
| Hamada, H | 1 |
| Ogawa, Y | 1 |
| Nakashima, M | 1 |
| Sasaki, H | 1 |
| Aikawa, K | 1 |
| Tanaka, T | 1 |
| Aoki, M | 1 |
| Harada, J | 1 |
| Moriuchi, H | 1 |
1 review available for donepezil and Intellectual Disability
| Article | Year |
|---|---|
Atypical aging in Down syndrome.
Topics: Adult; Aging; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dementia; Donepez | 2013 |
1 other study available for donepezil and Intellectual Disability
| Article | Year |
|---|---|
Dramatic improvement in Down syndrome-associated cognitive impairment with donepezil.
Topics: Adult; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Down Syndrome; Female; H | 2005 |