donepezil has been researched along with Injuries, Radiation in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All 24 patients had a primary brain tumor, mostly low-grade glioma." | 2.72 | Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. ( D'Agostino, RB; Lovato, J; Naughton, MJ; Rapp, SR; Robbins, ME; Rosdhal, R; Shaw, EG, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shaw, EG | 1 |
| Rosdhal, R | 1 |
| D'Agostino, RB | 1 |
| Lovato, J | 1 |
| Naughton, MJ | 1 |
| Robbins, ME | 1 |
| Rapp, SR | 1 |
| McCaffrey, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases[NCT00070161] | Phase 2 | 68 participants (Actual) | Interventional | 2001-07-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for donepezil and Injuries, Radiation
| Article | Year |
|---|---|
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life.
Topics: Adult; Affect; Aged; Anger; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Donepez | 2006 |
1 other study available for donepezil and Injuries, Radiation
| Article | Year |
|---|---|
Alzheimer's drug helps brain function after radiotherapy.
Topics: Alzheimer Disease; Brain Neoplasms; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents | 2006 |