donepezil has been researched along with Inflammation in 31 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we tested the hypothesis that donepezil would attenuate central inflammation and oxidative damage and improve memory deficit in high-fat diet (HFD)-fed mice." | 7.91 | Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet. ( Chen, J; Fu, X; Jiang, L; Ren, H; Su, L; Wang, C; Wang, Y, 2019) |
| "Colitis was evoked by a single transrectal injection of 1 ml of 4 % acetic acid." | 5.91 | Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity. ( Ahmed, KA; Elbaz, EM; Essam, RM; Safwat, MH, 2023) |
| "Donepezil has proven to be an effective drug to reduce neuronal death and subsequently injury in neurodegenerative diseases." | 5.62 | Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis. ( Aboutaleb, N; Golmohammadi, S; Madani Neishaboori, A; Nasseri Maleki, S; Nazarinia, D; Saberi Pirouz, M, 2021) |
| "Donepezil exerted cardioprotection against TIC via attenuating mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved LV function through mAChR activation." | 4.31 | Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| "In this study, we tested the hypothesis that donepezil would attenuate central inflammation and oxidative damage and improve memory deficit in high-fat diet (HFD)-fed mice." | 3.91 | Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet. ( Chen, J; Fu, X; Jiang, L; Ren, H; Su, L; Wang, C; Wang, Y, 2019) |
| "Chronic treatment with donepezil or pyridostigmine started before the onset of hypertension." | 3.81 | Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. ( Lataro, RM; Prado, CM; Salgado, HC; Silva, CA; Tefé-Silva, C, 2015) |
| "Colitis was evoked by a single transrectal injection of 1 ml of 4 % acetic acid." | 1.91 | Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity. ( Ahmed, KA; Elbaz, EM; Essam, RM; Safwat, MH, 2023) |
| " After drug treatment, the results showed that AD patients with HLJD combined with DON treatment didn't increase the adverse effects and had good compliance." | 1.91 | Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment. ( Huang, J; Xu, M; Yue, Y, 2023) |
| "Treatment with donepezil was administered from the 4th to the 6th month of life." | 1.62 | Donepezil improves vascular function in a mouse model of Alzheimer's disease. ( Antonioli, L; Baldacci, F; Bernardini, N; Blandizzi, C; D'Antongiovanni, V; Duranti, E; Fornai, M; Masi, S; Pellegrini, C; Taddei, S; Virdis, A, 2021) |
| "Donepezil has proven to be an effective drug to reduce neuronal death and subsequently injury in neurodegenerative diseases." | 1.62 | Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis. ( Aboutaleb, N; Golmohammadi, S; Madani Neishaboori, A; Nasseri Maleki, S; Nazarinia, D; Saberi Pirouz, M, 2021) |
| "Since aging and inflammation affect cognition and are risk factors for AD, these aspects were also evaluated." | 1.48 | The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges. ( Graf, R; Hughes, ZA; Longo, JL, 2018) |
| "Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease." | 1.46 | Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes. ( Akaike, A; Izumi, Y; Kume, T; Makitani, K; Nakagawa, S, 2017) |
| "Rolipram treatment significantly attenuated STZ induced and age related memory deficits, biochemical and histopathological alterations." | 1.46 | Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. ( Kumar, A; Singh, N, 2017) |
| "Inflammation has been recently implicated in pathogenesis of dementia disorders." | 1.34 | Effect of anti-dementia drugs on LPS induced neuroinflammation in mice. ( Agrawal, R; Nath, C; Shukla, R; Tyagi, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 17 (54.84) | 24.3611 |
| 2020's | 11 (35.48) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Wang, Y | 2 |
| Wang, B | 1 |
| Li, W | 1 |
| Huang, L | 1 |
| Li, X | 2 |
| Venkanna, A | 1 |
| Cho, KH | 1 |
| Dhorma, LP | 1 |
| Kumar, DN | 1 |
| Hah, JM | 1 |
| Park, HG | 1 |
| Kim, SY | 1 |
| Kim, MH | 1 |
| AlFadly, ED | 1 |
| Elzahhar, PA | 1 |
| Tramarin, A | 1 |
| Elkazaz, S | 1 |
| Shaltout, H | 1 |
| Abu-Serie, MM | 1 |
| Janockova, J | 1 |
| Soukup, O | 1 |
| Ghareeb, DA | 1 |
| El-Yazbi, AF | 1 |
| Rafeh, RW | 1 |
| Bakkar, NZ | 1 |
| Kobeissy, F | 1 |
| Iriepa, I | 1 |
| Moraleda, I | 1 |
| Saudi, MNS | 1 |
| Bartolini, M | 1 |
| Belal, ASF | 1 |
| Wang, D | 1 |
| Hu, M | 1 |
| Zhang, D | 1 |
| Chen, C | 1 |
| Fu, J | 1 |
| Shao, S | 1 |
| Shi, G | 1 |
| Zhou, Y | 1 |
| Wu, S | 1 |
| Zhang, T | 1 |
| Liu, Q | 1 |
| Liu, JP | 1 |
| Mei, JH | 1 |
| Li, SJ | 1 |
| Shi, LQ | 1 |
| Lin, ZH | 1 |
| Xie, BY | 1 |
| Sun, WG | 1 |
| Wang, ZY | 1 |
| Yang, XL | 1 |
| Zou, Y | 1 |
| Fang, W | 1 |
| Kim, J | 1 |
| Lee, HJ | 1 |
| Park, SK | 1 |
| Park, JH | 1 |
| Jeong, HR | 1 |
| Lee, S | 1 |
| Lee, H | 1 |
| Seol, E | 1 |
| Hoe, HS | 1 |
| Pellegrini, C | 1 |
| D'Antongiovanni, V | 1 |
| Fornai, M | 1 |
| Duranti, E | 1 |
| Baldacci, F | 1 |
| Bernardini, N | 1 |
| Taddei, S | 1 |
| Virdis, A | 1 |
| Blandizzi, C | 1 |
| Masi, S | 1 |
| Antonioli, L | 1 |
| Yilmaz, I | 1 |
| Akalan, H | 1 |
| Yasar Sirin, D | 1 |
| Karaarslan, N | 1 |
| Kaplan, N | 1 |
| Ozbek, H | 1 |
| Wiatrak, B | 1 |
| Krzyżak, E | 1 |
| Szczęśniak-Sięga, B | 1 |
| Szandruk-Bender, M | 1 |
| Szeląg, A | 1 |
| Nowak, B | 1 |
| Elbaz, EM | 1 |
| Essam, RM | 1 |
| Ahmed, KA | 1 |
| Safwat, MH | 1 |
| Anoush, M | 1 |
| Bijani, S | 1 |
| Moslemifar, F | 1 |
| Jahanpour, F | 1 |
| Kalantari-Hesari, A | 1 |
| Hosseini, MJ | 1 |
| Xu, M | 1 |
| Yue, Y | 1 |
| Huang, J | 1 |
| Khuanjing, T | 1 |
| Maneechote, C | 1 |
| Ongnok, B | 1 |
| Prathumsap, N | 1 |
| Arinno, A | 1 |
| Chunchai, T | 1 |
| Arunsak, B | 1 |
| Chattipakorn, SC | 1 |
| Chattipakorn, N | 1 |
| Swartzwelder, HS | 1 |
| Healey, KL | 1 |
| Liu, W | 1 |
| Dubester, K | 1 |
| Miller, KM | 1 |
| Crews, FT | 1 |
| Jiang, L | 1 |
| Su, L | 1 |
| Ren, H | 1 |
| Wang, C | 1 |
| Chen, J | 1 |
| Fu, X | 1 |
| Stær, K | 1 |
| Iranzo, A | 1 |
| Stokholm, MG | 1 |
| Østergaard, K | 1 |
| Serradell, M | 1 |
| Otto, M | 1 |
| Svendsen, KB | 1 |
| Garrido, A | 1 |
| Vilas, D | 1 |
| Santamaria, J | 1 |
| Møller, A | 1 |
| Gaig, C | 1 |
| Brooks, DJ | 1 |
| Borghammer, P | 1 |
| Tolosa, E | 1 |
| Pavese, N | 1 |
| Madani Neishaboori, A | 1 |
| Nasseri Maleki, S | 1 |
| Saberi Pirouz, M | 1 |
| Golmohammadi, S | 1 |
| Nazarinia, D | 1 |
| Aboutaleb, N | 1 |
| Makitani, K | 1 |
| Nakagawa, S | 1 |
| Izumi, Y | 1 |
| Akaike, A | 1 |
| Kume, T | 1 |
| Kokras, N | 1 |
| Stamouli, E | 1 |
| Sotiropoulos, I | 1 |
| Katirtzoglou, EA | 1 |
| Siarkos, KT | 1 |
| Dalagiorgou, G | 1 |
| Alexandraki, KI | 1 |
| Coulocheri, S | 1 |
| Piperi, C | 1 |
| Politis, AM | 1 |
| Watremez, W | 1 |
| Jackson, J | 1 |
| Almari, B | 1 |
| McLean, SL | 1 |
| Grayson, B | 1 |
| Neill, JC | 1 |
| Fischer, N | 1 |
| Allouche, A | 1 |
| Koziel, V | 1 |
| Pillot, T | 1 |
| Harte, MK | 1 |
| Kaundal, M | 1 |
| Deshmukh, R | 1 |
| Akhtar, M | 1 |
| Graf, R | 1 |
| Longo, JL | 1 |
| Hughes, ZA | 1 |
| Lataro, RM | 1 |
| Silva, CA | 1 |
| Tefé-Silva, C | 1 |
| Prado, CM | 1 |
| Salgado, HC | 1 |
| Dasuri, K | 1 |
| Zhang, L | 1 |
| Kim, SO | 1 |
| Bruce-Keller, AJ | 1 |
| Keller, JN | 1 |
| Arikawa, M | 1 |
| Kakinuma, Y | 1 |
| Noguchi, T | 1 |
| Todaka, H | 1 |
| Sato, T | 1 |
| Kumar, A | 1 |
| Singh, N | 1 |
| Yoshiyama, Y | 1 |
| Wang, J | 1 |
| Zhang, HY | 1 |
| Tang, XC | 1 |
| Inanaga, K | 1 |
| Ichiki, T | 1 |
| Miyazaki, R | 1 |
| Takeda, K | 1 |
| Hashimoto, T | 1 |
| Matsuura, H | 1 |
| Sunagawa, K | 1 |
| Kamat, PK | 1 |
| Tota, S | 1 |
| Rai, S | 1 |
| Swarnkar, S | 1 |
| Shukla, R | 2 |
| Nath, C | 2 |
| Tyagi, E | 1 |
| Agrawal, R | 1 |
2 reviews available for donepezil and Inflammation
| Article | Year |
|---|---|
[Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse].
Topics: Acetylcholine; Amyloid; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil | 2008 |
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Cholinergic Agents; Cholinesterase Inhi | 2009 |
29 other studies available for donepezil and Inflammation
| Article | Year |
|---|---|
Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Clioquinol; Cognition; | 2015 |
Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone.
Topics: Drug Discovery; Inflammation; Microglia; Neurodegenerative Diseases; Neuroprotective Agents; Nitric | 2019 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 In | 2019 |
Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cell L | 2019 |
Betulin isolated from Pyrola incarnata Fisch. inhibited lipopolysaccharide (LPS)-induced neuroinflammation with the guidance of computer-aided drug design.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Drug Design; Inflammation; Inflammation Mediat | 2020 |
Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Cholinesterase Inhib | 2021 |
Donepezil improves vascular function in a mouse model of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cardiovascular Diseases; Cholinesterase Inhibitors; Cogni | 2021 |
Effects of an acetylcholinesterase inhibitor and an N-methyl-D-aspartate receptor antagonist on inflammation and degeneration of the nucleus pulposus.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Female; Humans; Inflammation; Interverte | 2022 |
Effect of tricyclic 1,2-thiazine derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Coculture Techniques; Donepezil; Humans; Inflammation; | 2022 |
Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity.
Topics: Acetic Acid; Acetylcholinesterase; Animals; Antioxidants; Cognitive Dysfunction; Colitis; Colitis, U | 2023 |
Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters.
Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Donepezil; Edaravone; Inflammation | 2023 |
Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Animals; Donepezil; Drugs, Chinese Herbal; Inflammation; Interleukin-6; Metabolom | 2023 |
Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways.
Topics: Acetylcholinesterase; Animals; Apoptosis; Cardiotoxicity; Donepezil; Inflammation; Male; Rats; Rats, | 2023 |
Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil.
Topics: Acetylation; Animals; Cell Death; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Donepezil | 2019 |
Donepezil Attenuates Obesity-Associated Oxidative Stress and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet.
Topics: Animals; Diet, High-Fat; Donepezil; Glycation End Products, Advanced; Inflammation; Insulin Resistan | 2019 |
Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder.
Topics: Acetylcholinesterase; Aged; Carbon Radioisotopes; Cerebral Cortex; Cholinesterase Inhibitors; Cognit | 2020 |
Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis.
Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Donepezil; Dose-Response Relationship, Drug; Infar | 2021 |
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes.
Topics: Acetylcholinesterase; Animals; Astrocytes; Bradykinin; Calcium; Cells, Cultured; Cerebral Cortex; Ch | 2017 |
Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytokines in Early Stages of Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cytokines; Donepezil; Female; Follow-Up Studies; | 2018 |
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A | 2018 |
Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possible neurotransmitters and neuroinflammatory mechanism.
Topics: Acetylcholinesterase; Animals; Betulinic Acid; Cognitive Dysfunction; Disease Models, Animal; Donepe | 2018 |
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.
Topics: Aging; Animals; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Donepezil | 2018 |
Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Cholinesterase Inhibitors; Cytokines; Donepezil; Drug Evaluation, Preclinic | 2015 |
Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.
Topics: Animals; Brain; Cholinesterase Inhibitors; Diet, High-Fat; Donepezil; Inflammation; Male; Mice, Inbr | 2016 |
Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation.
Topics: Acetylcholinesterase; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cell Nucleu | 2016 |
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibit | 2017 |
Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Atherosclerosis; Cardiovascular Diseases; Cholinester | 2010 |
A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats.
Topics: Animals; Behavior, Animal; Biomarkers; Blotting, Western; Donepezil; Excitatory Amino Acid Antagonis | 2012 |
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Dementia; Don | 2007 |