donepezil has been researched along with Hypertension in 6 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "0 years) with probable or possible VaD, according to National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche en l'Enseignement en Neurosciences criteria, were randomized to receive donepezil 5 mg/day (n = 208), donepezil 10 mg/day (after 5 mg/day for the first 28 days) (n = 215), or placebo (n = 193) for 24 weeks." | 5.10 | Donepezil in vascular dementia: a randomized, placebo-controlled study. ( Doody, R; Helme, R; Kertesz, A; Mintzer, J; Pratt, RD; Taubman, K; Wilkinson, D, 2003) |
| "Chronic treatment with donepezil or pyridostigmine started before the onset of hypertension." | 3.81 | Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. ( Lataro, RM; Prado, CM; Salgado, HC; Silva, CA; Tefé-Silva, C, 2015) |
| " Considering that vascular dysfunction is a crucial feature of arterial hypertension, we investigated the effects of chronic administration of acetylcholinesterase inhibitors-pyridostigmine or donepezil-on vascular reactivity of spontaneously hypertensive rats (SHR)." | 1.51 | Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats. ( Cau, SBA; Lataro, RM; Mestriner, FL; Salgado, HC; Silva, MAB; Tostes, RCA, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cavalcante, GL | 1 |
| Ferreira, FN | 1 |
| da Silva, MTB | 1 |
| Soriano, RN | 1 |
| Filho, ALMM | 1 |
| Arcanjo, DDR | 1 |
| Sabino, JPJ | 1 |
| Lataro, RM | 2 |
| Silva, MAB | 1 |
| Mestriner, FL | 1 |
| Cau, SBA | 1 |
| Tostes, RCA | 1 |
| Salgado, HC | 2 |
| Silva, CA | 1 |
| Tefé-Silva, C | 1 |
| Prado, CM | 1 |
| Wilkinson, D | 1 |
| Doody, R | 1 |
| Helme, R | 1 |
| Taubman, K | 1 |
| Mintzer, J | 1 |
| Kertesz, A | 1 |
| Pratt, RD | 1 |
| Kouta, Y | 1 |
| Sakurai, T | 1 |
| Yokono, K | 1 |
| Martínez-Vila, E | 1 |
| Murie-Fernández, M | 1 |
| Gállego Pérez-Larraya, J | 1 |
| Irimia, P | 1 |
1 review available for donepezil and Hypertension
| Article | Year |
|---|---|
[Cognitive dysfunction and dementia associated with elderly diabetes].
Topics: Aged; Antihypertensive Agents; Brain; Cognition Disorders; Dementia; Diabetes Mellitus, Type 2; Done | 2006 |
1 trial available for donepezil and Hypertension
| Article | Year |
|---|---|
Donepezil in vascular dementia: a randomized, placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Double-Bli | 2003 |
4 other studies available for donepezil and Hypertension
| Article | Year |
|---|---|
Acetylcholinesterase inhibition prevents alterations in cardiovascular autonomic control and gastric motility in L-NAME-induced hypertensive rats.
Topics: Acetylcholinesterase; Animals; Arterial Pressure; Autonomic Nervous System; Baroreflex; Cardiovascul | 2020 |
Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats.
Topics: Acetylcholinesterase; Animals; Antihypertensive Agents; Arterial Pressure; Cholinesterase Inhibitors | 2019 |
Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Cholinesterase Inhibitors; Cytokines; Donepezil; Drug Evaluation, Preclinic | 2015 |
Neuroprotection in vascular dementia.
Topics: Animals; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Excitatory Amino Acid Antagonists | 2006 |