Page last updated: 2024-10-26

donepezil and Huntington Disease

donepezil has been researched along with Huntington Disease in 3 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
" We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD."9.12Effect of donepezil on motor and cognitive function in Huntington disease. ( Bernard, BA; Cubo, E; Jaglin, JA; Leurgans, SE; Shannon, KM; Tracy, D; Wuu, J, 2006)
" We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD."5.12Effect of donepezil on motor and cognitive function in Huntington disease. ( Bernard, BA; Cubo, E; Jaglin, JA; Leurgans, SE; Shannon, KM; Tracy, D; Wuu, J, 2006)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cavalli, A1
Bolognesi, ML1
Minarini, A1
Rosini, M1
Tumiatti, V1
Recanatini, M1
Melchiorre, C1
Cubo, E1
Shannon, KM1
Tracy, D1
Jaglin, JA1
Bernard, BA1
Wuu, J1
Leurgans, SE1
Fernandez, HH1
Friedman, JH1
Grace, J1
Beason-Hazen, S1

Reviews

1 review available for donepezil and Huntington Disease

ArticleYear
Multi-target-directed ligands to combat neurodegenerative diseases.
    Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Calcium

2008

Trials

2 trials available for donepezil and Huntington Disease

ArticleYear
Effect of donepezil on motor and cognitive function in Huntington disease.
    Neurology, 2006, Oct-10, Volume: 67, Issue:7

    Topics: Chorea; Cognition Disorders; Donepezil; Female; Humans; Huntington Disease; Indans; Male; Middle Age

2006
Donepezil for Huntington's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2000, Volume: 15, Issue:1

    Topics: Adult; Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Huntington Disease; Indans; Male;

2000