donepezil has been researched along with Hip Fractures in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair." | 9.15 | Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. ( Appleton, P; Davis, RB; Marcantonio, ER; Palihnich, K, 2011) |
| "To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair." | 5.15 | Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. ( Appleton, P; Davis, RB; Marcantonio, ER; Palihnich, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seitz, DP | 1 |
| Gill, SS | 1 |
| Gruneir, A | 1 |
| Austin, PC | 1 |
| Anderson, G | 1 |
| Reimer, CL | 1 |
| Rochon, PA | 1 |
| Marcantonio, ER | 1 |
| Palihnich, K | 1 |
| Appleton, P | 1 |
| Davis, RB | 1 |
| Tamimi, I | 1 |
| Ojea, T | 1 |
| Sanchez-Siles, JM | 1 |
| Rojas, F | 1 |
| Martin, I | 1 |
| Gormaz, I | 1 |
| Perez, A | 1 |
| Dawid-Milner, MS | 1 |
| Mendez, L | 1 |
| Tamimi, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period[NCT00586196] | Phase 2 | 16 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measures severity of 10 delirium symptoms items (0 not present, 1 mild, 2 moderate, 3 severe) yielding a total score of 0 to 30, with 30 most severe. (NCT00586196)
Timeframe: Baseline, hospital discharge, weeks 2, 4 and 6
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Change at Hospital Discharge | Change at Week 2 | Change at week 4 | Change at week 6 | |
| Donepezil : 5 mg Each Day for 30 Days | 6.3 | 1.3 | -0.1 | -1.2 | -0.6 |
| Placebo : Encapsulated Cornstarch | 8.4 | 1.6 | -2.2 | -2.0 | -2.0 |
Confusion Assessment Method (CAM)-Measure of the presence or absence of delirium. Requires 1) acute change with fluctuating course, 2) inattention, and either 3) disorganized thinking or 4) altered level of consciousness. (NCT00586196)
Timeframe: Baseline, hospital interviews, weeks 2, 4 and 6
| Intervention | percentage of participants (Number) | ||||
|---|---|---|---|---|---|
| basline | hospital interviews | Week 2 | week 4 | week 6 | |
| Donepezil : 5 mg Each Day for 30 Days | 14 | 64 | 43 | 17 | 50 |
| Placebo : Encapsulated Cornstarch | 44 | 64 | 43 | 43 | 50 |
1 trial available for donepezil and Hip Fractures
| Article | Year |
|---|---|
Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delirium; Donepezil; Double-Blind Method; Female | 2011 |
2 other studies available for donepezil and Hip Fractures
| Article | Year |
|---|---|
Effects of cholinesterase inhibitors on postoperative outcomes of older adults with dementia undergoing hip fracture surgery.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Cholinesterase Inhibitors; Cohort Studies; Critical Ca | 2011 |
Acetylcholinesterase inhibitors and the risk of hip fracture in Alzheimer's disease patients: a case-control study.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Body Mass Index; Case-Control Stud | 2012 |