donepezil has been researched along with Heart Failure in 9 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 8.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF)." | 7.96 | Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2020) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 7.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 5.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| "Donepezil was orally given at a dosage of 5 mgxkg(-1)xday(-1)." | 5.35 | Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. ( Ando, M; Arikawa, M; Handa, T; Kakinuma, Y; Katare, RG; Sasaguri, S; Sato, T; Yamasaki, F, 2009) |
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 4.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Oral administration of donepezil, a centrally acting acetylcholinesterase inhibitor, improves the survival of rats with chronic heart failure (CHF)." | 3.96 | Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2020) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 3.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| "Donepezil treatment started 14 days after MI significantly decreased the heart rate (325 ± 6 vs." | 1.39 | Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. ( Inagaki, M; Kawada, T; Li, M; Shishido, T; Sugimachi, M; Uemura, K; Zheng, C, 2013) |
| "Memantine was also associated with greater risk of all-cause mortality in the Medicare (HR = 1." | 1.38 | Comparative cardiovascular safety of dementia medications: a cross-national study. ( Curtis, LH; Fosbøl, EL; Gislason, GH; Holm, E; Iwata, I; Køber, L; Peterson, ED; Setoguchi, S; Torp-Pedersen, C; Zhang, Y, 2012) |
| "Donepezil was orally given at a dosage of 5 mgxkg(-1)xday(-1)." | 1.35 | Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. ( Ando, M; Arikawa, M; Handa, T; Kakinuma, Y; Katare, RG; Sasaguri, S; Sato, T; Yamasaki, F, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Li, M | 6 |
| Zheng, C | 6 |
| Kawada, T | 5 |
| Uemura, K | 5 |
| Inagaki, M | 5 |
| Saku, K | 1 |
| Sugimachi, M | 6 |
| Akiyama, T | 1 |
| Shishido, T | 1 |
| Handa, T | 1 |
| Katare, RG | 1 |
| Kakinuma, Y | 2 |
| Arikawa, M | 1 |
| Ando, M | 1 |
| Sasaguri, S | 1 |
| Yamasaki, F | 2 |
| Sato, T | 2 |
| Okazaki, Y | 1 |
| Kubo, T | 1 |
| Noguchi, T | 1 |
| Kitaoka, H | 1 |
| Kamimura, N | 1 |
| Shimodera, S | 1 |
| Iiyama, T | 1 |
| Kumagai, N | 1 |
| Diedrich, A | 1 |
| Jordan, J | 1 |
| Robertson, D | 1 |
| Doi, YL | 1 |
| Fosbøl, EL | 1 |
| Peterson, ED | 1 |
| Holm, E | 1 |
| Gislason, GH | 1 |
| Zhang, Y | 1 |
| Curtis, LH | 1 |
| Køber, L | 1 |
| Iwata, I | 1 |
| Torp-Pedersen, C | 1 |
| Setoguchi, S | 1 |
9 other studies available for donepezil and Heart Failure
| Article | Year |
|---|---|
Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Donepezil; Heart Failure; Metoprolol; Myocardial Infarction; R | 2022 |
Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Fibrosis; Heart Failure; Injections, Intraventricular | 2020 |
Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Cholinesterase Inhibito | 2021 |
Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction.
Topics: Animals; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Heart Failure; Indans; Male; Myocard | 2013 |
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cholinesterase Inhibitors; Chronic Disease; Diseas | 2014 |
Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Donepezil; Heart Failure; Indans; Male; Mice; Pi | 2009 |
Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Heart; Heart Failure; Heart Rate; Indans; Male; Myoca | 2010 |
Influences of donepezil on cardiovascular system--possible therapeutic benefits for heart failure--donepezil cardiac test registry (DOCTER) study.
Topics: Aged; Aged, 80 and over; Cardiovascular Physiological Phenomena; Donepezil; Female; Follow-Up Studie | 2012 |
Comparative cardiovascular safety of dementia medications: a cross-national study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cohort Studies; Dementia; Denmark; Donepezil; Fe | 2012 |