donepezil has been researched along with Heart Diseases in 5 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since cardiac autonomic modulation with electrical vagus nerve stimulation (VNS) and acetylcholinesterase (AChE) inhibitors exerts cardioprotection against various heart diseases, the comparative effects of electrical VNS and an AChE inhibitor (donepezil) on cardiac and mitochondrial functions and programmed cell death pathways in TIC are not known." | 8.31 | Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| "0 years) with probable or possible VaD, according to National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche en l'Enseignement en Neurosciences criteria, were randomized to receive donepezil 5 mg/day (n = 208), donepezil 10 mg/day (after 5 mg/day for the first 28 days) (n = 215), or placebo (n = 193) for 24 weeks." | 5.10 | Donepezil in vascular dementia: a randomized, placebo-controlled study. ( Doody, R; Helme, R; Kertesz, A; Mintzer, J; Pratt, RD; Taubman, K; Wilkinson, D, 2003) |
| " Since cardiac autonomic modulation with electrical vagus nerve stimulation (VNS) and acetylcholinesterase (AChE) inhibitors exerts cardioprotection against various heart diseases, the comparative effects of electrical VNS and an AChE inhibitor (donepezil) on cardiac and mitochondrial functions and programmed cell death pathways in TIC are not known." | 4.31 | Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction. ( Arinno, A; Arunsak, B; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Khuanjing, T; Maneechote, C; Ongnok, B; Prathumsap, N, 2023) |
| "Hydroxychloroquine has been widely prescribed to treat patients with COVID-19 pneumonia." | 1.62 | Torsades de pointes in SARS-CoV-2 (COVID-19) pneumonia: medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications. ( Ali, N; Aslam, W; Lamb, CR, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khuanjing, T | 1 |
| Maneechote, C | 1 |
| Ongnok, B | 1 |
| Prathumsap, N | 1 |
| Arinno, A | 1 |
| Chunchai, T | 1 |
| Arunsak, B | 1 |
| Chattipakorn, SC | 1 |
| Chattipakorn, N | 1 |
| Aslam, W | 1 |
| Lamb, CR | 1 |
| Ali, N | 1 |
| Kubo, T | 1 |
| Sato, T | 1 |
| Noguchi, T | 1 |
| Kitaoka, H | 1 |
| Yamasaki, F | 1 |
| Kamimura, N | 1 |
| Shimodera, S | 1 |
| Iiyama, T | 1 |
| Kumagai, N | 1 |
| Kakinuma, Y | 1 |
| Diedrich, A | 1 |
| Jordan, J | 1 |
| Robertson, D | 1 |
| Doi, YL | 1 |
| Wilkinson, D | 1 |
| Doody, R | 1 |
| Helme, R | 1 |
| Taubman, K | 1 |
| Mintzer, J | 1 |
| Kertesz, A | 1 |
| Pratt, RD | 1 |
| Martínez-Vila, E | 1 |
| Murie-Fernández, M | 1 |
| Gállego Pérez-Larraya, J | 1 |
| Irimia, P | 1 |
1 trial available for donepezil and Heart Diseases
| Article | Year |
|---|---|
Donepezil in vascular dementia: a randomized, placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Double-Bli | 2003 |
4 other studies available for donepezil and Heart Diseases
| Article | Year |
|---|---|
Vagus nerve stimulation and acetylcholinesterase inhibitor donepezil provide cardioprotection against trastuzumab-induced cardiotoxicity in rats by attenuating mitochondrial dysfunction.
Topics: Acetylcholinesterase; Animals; Cardiotoxicity; Cholinesterase Inhibitors; Donepezil; Heart Diseases; | 2023 |
Torsades de pointes in SARS-CoV-2 (COVID-19) pneumonia: medicine reconciliation and careful monitoring of QTc interval may help prevent cardiac complications.
Topics: Aged; Anti-Infective Agents; Citalopram; COVID-19 Drug Treatment; Dexamethasone; Donepezil; Drug The | 2021 |
Influences of donepezil on cardiovascular system--possible therapeutic benefits for heart failure--donepezil cardiac test registry (DOCTER) study.
Topics: Aged; Aged, 80 and over; Cardiovascular Physiological Phenomena; Donepezil; Female; Follow-Up Studie | 2012 |
Neuroprotection in vascular dementia.
Topics: Animals; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Excitatory Amino Acid Antagonists | 2006 |