Page last updated: 2024-10-26

donepezil and Glioma

donepezil has been researched along with Glioma in 2 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"All 24 patients had a primary brain tumor, mostly low-grade glioma."2.72Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. ( D'Agostino, RB; Lovato, J; Naughton, MJ; Rapp, SR; Robbins, ME; Rosdhal, R; Shaw, EG, 2006)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, BF1
Peng, FF1
Zhang, JZ1
Wu, DC1
Shaw, EG1
Rosdhal, R1
D'Agostino, RB1
Lovato, J1
Naughton, MJ1
Robbins, ME1
Rapp, SR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases[NCT00070161]Phase 268 participants (Actual)Interventional2001-07-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for donepezil and Glioma

ArticleYear
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Mar-20, Volume: 24, Issue:9

    Topics: Adult; Affect; Aged; Anger; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Donepez

2006

Other Studies

1 other study available for donepezil and Glioma

ArticleYear
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:2

    Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells;

2002