donepezil has been researched along with Fragile X Syndrome in 5 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed as a 12-week, randomized, double-blind, placebo-controlled pilot study to evaluate the effectiveness and safety of donepezil in boys with fragile X syndrome." | 9.17 | Effectiveness and safety of donepezil in boys with fragile x syndrome: a double-blind, randomized, controlled pilot study. ( Arya, R; Chauhan, S; Chowdhury, MR; Dwivedi, SN; Gulati, S; Gupta, N; Gupta, YK; Kabra, M; Kalra, V; Sahu, JK; Sapra, S, 2013) |
| "The present study was designed as a 12-week, randomized, double-blind, placebo-controlled pilot study to evaluate the effectiveness and safety of donepezil in boys with fragile X syndrome." | 5.17 | Effectiveness and safety of donepezil in boys with fragile x syndrome: a double-blind, randomized, controlled pilot study. ( Arya, R; Chauhan, S; Chowdhury, MR; Dwivedi, SN; Gulati, S; Gupta, N; Gupta, YK; Kabra, M; Kalra, V; Sahu, JK; Sapra, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno, JL | 1 |
| Hosseini, SH | 1 |
| Lightbody, AA | 2 |
| Manchanda, MK | 1 |
| Reiss, AL | 2 |
| Kesler, SR | 1 |
| Hagerman, R | 2 |
| Lauterborn, J | 1 |
| Au, J | 1 |
| Berry-Kravis, E | 1 |
| Sahu, JK | 1 |
| Gulati, S | 1 |
| Sapra, S | 1 |
| Arya, R | 1 |
| Chauhan, S | 1 |
| Chowdhury, MR | 1 |
| Gupta, N | 1 |
| Kabra, M | 1 |
| Gupta, YK | 1 |
| Dwivedi, SN | 1 |
| Kalra, V | 1 |
| Bourgeois, JA | 1 |
| Farzin, F | 1 |
| Brunberg, JA | 1 |
| Tassone, F | 1 |
| Hagerman, P | 1 |
| Zhang, L | 1 |
| Hessl, D | 1 |
1 review available for donepezil and Fragile X Syndrome
| Article | Year |
|---|---|
Fragile X syndrome and targeted treatment trials.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Baclofen; Brain-Derived Neurotrophic Factor; Central N | 2012 |
3 trials available for donepezil and Fragile X Syndrome
| Article | Year |
|---|---|
Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome.
Topics: Adolescent; Adult; Brain; Child; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezi | 2019 |
Cholinergic dysfunction in fragile X syndrome and potential intervention: a preliminary 1H MRS study.
Topics: Adolescent; Adult; Case-Control Studies; Choline; Cholinesterase Inhibitors; Cognition; Creatine; Do | 2009 |
Effectiveness and safety of donepezil in boys with fragile x syndrome: a double-blind, randomized, controlled pilot study.
Topics: Adolescent; Child; Child Behavior Disorders; Child Development Disorders, Pervasive; Donepezil; Dose | 2013 |
1 other study available for donepezil and Fragile X Syndrome
| Article | Year |
|---|---|
Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine.
Topics: Aged; Antidepressive Agents, Second-Generation; Ataxia; Atrophy; Brain; Cyclohexanols; Dementia; Dom | 2006 |