donepezil has been researched along with Encephalopathy, Toxic in 5 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is a potent and selective acetylcholinesterase (AChE) inhibitor developed for the treatment of Alzheimer's disease." | 1.32 | Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons. ( Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Sugimoto, H; Takada, Y; Yonezawa, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shaik, JB | 1 |
| Palaka, BK | 1 |
| Penumala, M | 1 |
| Kotapati, KV | 1 |
| Devineni, SR | 1 |
| Eadlapalli, S | 1 |
| Darla, MM | 1 |
| Ampasala, DR | 1 |
| Vadde, R | 1 |
| Amooru, GD | 1 |
| Takada, Y | 1 |
| Yonezawa, A | 1 |
| Kume, T | 1 |
| Katsuki, H | 1 |
| Kaneko, S | 1 |
| Sugimoto, H | 1 |
| Akaike, A | 1 |
| Janowsky, DS | 1 |
| Davis, JM | 1 |
| Overstreet, DH | 1 |
| Creeley, CE | 1 |
| Wozniak, DF | 1 |
| Nardi, A | 1 |
| Farber, NB | 1 |
| Olney, JW | 1 |
| Duysen, EG | 1 |
| Li, B | 1 |
| Darvesh, S | 1 |
| Lockridge, O | 1 |
5 other studies available for donepezil and Encephalopathy, Toxic
| Article | Year |
|---|---|
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Binding Sites; Butyrylcholinesterase | 2016 |
Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Donepezil; Drug Antagonism; Glutamic Acid; Ind | 2003 |
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study.
Topics: Animals; Behavior, Animal; Body Temperature; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug In | 2004 |
Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Cholinesterase Inhibitors; Donepezil; Dose-Response Re | 2008 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; C | 2007 |