donepezil has been researched along with Drop Attack in 11 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with AD treated with donepezil, a noninvasive evaluation identified a probable cause of syncope in over two-thirds of patients." | 7.73 | Causes of syncope in patients with Alzheimer's disease treated with donepezil. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Reynard, C; Robert, F, 2005) |
| " The drug was administered at a dosage of 5 mg/day for 1 month and 10 mg/day for the following 7 months, as tolerated." | 6.72 | Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Margaine, J; Robert, F, 2006) |
| "Donepezil is a commonly used drug in older people that due to its procholinergic effects can provoke bradycardia and neurocardiogenic syncope." | 3.78 | Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study. ( Anderson, GM; Daneman, N; Fischer, HD; Gill, SS; Gruneir, A; Hutson, JR; Rochon, PA; Wang, X, 2012) |
| "In patients with AD treated with donepezil, a noninvasive evaluation identified a probable cause of syncope in over two-thirds of patients." | 3.73 | Causes of syncope in patients with Alzheimer's disease treated with donepezil. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Reynard, C; Robert, F, 2005) |
| "We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil)." | 3.72 | Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors. ( Barold, SS; Bordier, P; Bressolles, N; Clémenty, J; Garrigue, S; Lanusse, S, 2003) |
| "There was no association with accidental injuries or fractures." | 3.01 | Cholinesterase inhibitors and falls, syncope and injuries in patients with cognitive impairment: a systematic review and meta-analysis. ( Ahuja, M; Gabor, C; Karimi, A; Lee, J; Lewis, K; Patterson, C; Reppas-Rindlisbacher, C; Siddhpuria, S; Sood, E; Wong, E, 2023) |
| " The drug was administered at a dosage of 5 mg/day for 1 month and 10 mg/day for the following 7 months, as tolerated." | 2.72 | Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease. ( Bordier, P; Garrigue, S; Gencel, L; Lafitte, A; Lanusse, S; Margaine, J; Robert, F, 2006) |
| "His only medical history was mild Alzheimer's disease diagnosed 6 months prior." | 2.52 | Upper gastrointestinal bleed associated with cholinesterase inhibitor use. ( Kok, KS; Loke, Y; Southgate, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ahuja, M | 1 |
| Siddhpuria, S | 1 |
| Karimi, A | 1 |
| Lewis, K | 1 |
| Wong, E | 1 |
| Lee, J | 1 |
| Reppas-Rindlisbacher, C | 1 |
| Sood, E | 1 |
| Gabor, C | 1 |
| Patterson, C | 1 |
| Jackson, EG | 1 |
| Stowe, S | 1 |
| Kok, KS | 1 |
| Loke, Y | 1 |
| Southgate, J | 1 |
| Kitt, J | 1 |
| Irons, R | 1 |
| Al-Obaidi, M | 1 |
| Missouris, C | 1 |
| Takaya, T | 1 |
| Okamoto, M | 1 |
| Yodoi, K | 1 |
| Hata, K | 1 |
| Kijima, Y | 1 |
| Nakajima, H | 1 |
| Nishikawa, Y | 1 |
| Kita, T | 1 |
| Ito, M | 1 |
| Seo, T | 1 |
| Kawashima, S | 1 |
| Hutson, JR | 1 |
| Fischer, HD | 1 |
| Wang, X | 1 |
| Gruneir, A | 1 |
| Daneman, N | 1 |
| Gill, SS | 1 |
| Rochon, PA | 1 |
| Anderson, GM | 1 |
| McLaren, AT | 1 |
| Allen, J | 1 |
| Murray, A | 1 |
| Ballard, CG | 1 |
| Kenny, RA | 1 |
| Bordier, P | 3 |
| Garrigue, S | 3 |
| Barold, SS | 1 |
| Bressolles, N | 1 |
| Lanusse, S | 3 |
| Clémenty, J | 1 |
| Jane Newby, V | 1 |
| Anne Kenny, R | 1 |
| McKeith, IG | 1 |
| Reynard, C | 1 |
| Robert, F | 2 |
| Gencel, L | 2 |
| Lafitte, A | 2 |
| Margaine, J | 1 |
2 reviews available for donepezil and Drop Attack
| Article | Year |
|---|---|
Cholinesterase inhibitors and falls, syncope and injuries in patients with cognitive impairment: a systematic review and meta-analysis.
Topics: Accidental Falls; Accidental Injuries; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; | 2023 |
Upper gastrointestinal bleed associated with cholinesterase inhibitor use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Duodenal Ulcer; Endoscop | 2015 |
2 trials available for donepezil and Drop Attack
| Article | Year |
|---|---|
Cardiovascular effects of donepezil in patients with dementia.
Topics: Aged; Autonomic Nervous System; Cardiovascular System; Cholinesterase Inhibitors; Dementia; Donepezi | 2003 |
Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Pressure; Cardiovascular System; Cholinesterase In | 2006 |
7 other studies available for donepezil and Drop Attack
| Article | Year |
|---|---|
Lesson of the month 1: Prolonged QT syndrome due to donepezil: a reversible cause of falls?
Topics: Accidental Falls; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Long QT Syndrome; | 2019 |
A case of donepezil-related torsades de pointes.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiopulmonary Resuscitation; Donepezil; Electrocardiography; | 2015 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiogr | 2009 |
Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrioventricular Block; Bradycardia; Cardiovascular | 2012 |
Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Femal | 2003 |
Donepezil and cardiac syncope: case report.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electrocardiography, Ambulatory; Fema | 2004 |
Causes of syncope in patients with Alzheimer's disease treated with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; In | 2005 |