donepezil has been researched along with Disease Models, Animal in 168 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, a Drosophila AD model and SH-SY5Y clles were used to assess the toxicity of SIP3, and APPswe/PS1dE9 (APP/PS1) transgenic mice were used to evaluate the cognitive-behavioral and depression-like behavior effect of SIP3 and donepezil co-treatment on symptoms of AD." | 8.12 | Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease. ( Chin, YW; Choi, H; Kanmani, S; Kim, KK; Kim, KW; Kim, SN; Kim, YM; Koo, BS; Liu, QF; Son, T, 2022) |
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 8.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Here, we characterize the effects of 24-h donepezil administration on anxiety-like behavioral and endocrine responses in adult zebrafish." | 7.96 | An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. ( Bueno, BW; de Abreu, MS; Demin, KA; Genario, R; Giacomini, AC; Kalueff, AV; Kolesnikova, TO; Marcon, L; Scolari, N, 2020) |
| "Donepezil is the first-line of treatment for Alzheimer's disease (AD), which improves cognitive impairment effectively, but whether it has an impact on cognitive impairment in schizophrenia remains unknown." | 7.88 | The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. ( Chen, T; He, L; Jia, XF; Li, YX; Ye, ZH, 2018) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 7.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| "The present study investigates the anti-amnesic potential of clioquinol (5-chloro-7-iodoquinolin-8-ol) in cognitive deficits associated with experimental dementia induced by Cu-Ch." | 7.81 | Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice. ( Aggarwal, N; Mehra, R; Sodhi, RK, 2015) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 7.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 7.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| " In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils." | 7.78 | Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. ( Cai, J; Cao, Y; Chen, T; Guo, F; Mao, X; Min, D; Shaw, C; Wang, L; Wu, K; Xie, N; Zhu, S, 2012) |
| " Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment." | 7.76 | Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 7.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "The comparative effects of a newly described specific alpha7 nAChR partial agonist, S 24795, and a cholinesterase inhibitor, donepezil, currently used as a symptomatic Alzheimer's disease treatment were studied in two mouse models of aging-related memory deficits." | 7.74 | Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. ( Desmedt, A; Marighetto, A; Morain, P; Philippin, JN; Trocmé-Thibierge, C; Valerio, S, 2008) |
| "Ferulic acid (FA) acts as a powerful antioxidant against various age-related diseases." | 5.43 | Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model. ( Gao, J; Gao, W; Huo, L; Qu, Z; Yang, H; Zhang, J, 2016) |
| " Donepezil was orally given at a dosage of 5 mgxkg(-1)xday(-1)." | 5.35 | Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. ( Ando, M; Arikawa, M; Handa, T; Kakinuma, Y; Katare, RG; Sasaguri, S; Sato, T; Yamasaki, F, 2009) |
| "In this study, a Drosophila AD model and SH-SY5Y clles were used to assess the toxicity of SIP3, and APPswe/PS1dE9 (APP/PS1) transgenic mice were used to evaluate the cognitive-behavioral and depression-like behavior effect of SIP3 and donepezil co-treatment on symptoms of AD." | 4.12 | Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease. ( Chin, YW; Choi, H; Kanmani, S; Kim, KK; Kim, KW; Kim, SN; Kim, YM; Koo, BS; Liu, QF; Son, T, 2022) |
| "Pharmacological modulation of parasympathetic activity with donepezil, an acetylcholinesterase inhibitor, improves the long-term survival of rats with chronic heart failure (CHF) after myocardial infarction (MI)." | 4.02 | Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats. ( Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2021) |
| "Here, we characterize the effects of 24-h donepezil administration on anxiety-like behavioral and endocrine responses in adult zebrafish." | 3.96 | An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish. ( Bueno, BW; de Abreu, MS; Demin, KA; Genario, R; Giacomini, AC; Kalueff, AV; Kolesnikova, TO; Marcon, L; Scolari, N, 2020) |
| "Donepezil is the first-line of treatment for Alzheimer's disease (AD), which improves cognitive impairment effectively, but whether it has an impact on cognitive impairment in schizophrenia remains unknown." | 3.88 | The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. ( Chen, T; He, L; Jia, XF; Li, YX; Ye, ZH, 2018) |
| ") on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i." | 3.88 | The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. ( Al-Houqani, M; Azimullah, S; Eissa, N; Jalal, FY; Jayaprakash, P; Kieć-Kononowicz, K; Ojha, SK; Sadek, B; Łażewska, D, 2018) |
| "The present study investigates the anti-amnesic potential of clioquinol (5-chloro-7-iodoquinolin-8-ol) in cognitive deficits associated with experimental dementia induced by Cu-Ch." | 3.81 | Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice. ( Aggarwal, N; Mehra, R; Sodhi, RK, 2015) |
| " In this study, we tested the effects of a synthesized juxtaposition (named SCR1693) composed of an acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB) on the hyperhomocysteinemia (HHcy)-induced AD rat model, and found that SCR1693 remarkably improved the HHcy-induced memory deficits and preserved dendrite morphologies as well as spine density by upregulating synapse-associated proteins PSD95 and synapsin-1." | 3.80 | Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats. ( Chen, R; Hu, J; Liu, R; Liu, X; Tian, Q; Wang, JZ; Wang, P; Wang, Q; Wang, XC; Xia, Y; Zeng, K, 2014) |
| "Modulation of vagal tone using electrical vagal nerve stimulation or pharmacological acetylcholinesterase inhibition by donepezil exerts beneficial effects in an animal model of chronic heart failure (CHF)." | 3.80 | Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure. ( Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C, 2014) |
| " In the present study, we reported that donepezil, a cholinesterase inhibitor, improved transient global cerebral ischemia-induced spatial memory impairment in gerbils." | 3.78 | Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils. ( Cai, J; Cao, Y; Chen, T; Guo, F; Mao, X; Min, D; Shaw, C; Wang, L; Wu, K; Xie, N; Zhu, S, 2012) |
| " Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment." | 3.76 | Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010) |
| " Therefore, the present study was designed to investigate the influence of antidementia drugs, tacrine and donepezil, on biochemical markers of oxidative stress, glutathione (GSH) and malondialdehyde (MDA), and acetylcholinesterase activity in the brain in a streptozotocin-induced experimental model of dementia in mice." | 3.74 | Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. ( Agrawal, R; Nath, C; Saxena, G; Singh, SP, 2008) |
| "The comparative effects of a newly described specific alpha7 nAChR partial agonist, S 24795, and a cholinesterase inhibitor, donepezil, currently used as a symptomatic Alzheimer's disease treatment were studied in two mouse models of aging-related memory deficits." | 3.74 | Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. ( Desmedt, A; Marighetto, A; Morain, P; Philippin, JN; Trocmé-Thibierge, C; Valerio, S, 2008) |
| "Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy." | 3.01 | From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. ( Bennett, KA; Bradley, SJ; Broad, LM; Brown, AJH; Brown, GA; Brown, J; Browning, M; Bundgaard, C; Cansfield, JE; Christopoulos, A; Congreve, MS; Cooke, RM; Cross, DM; Dawson, GR; de Graaf, C; Deakin, JFW; Dias, JM; Dwomoh, L; Errey, JC; Goonawardena, AV; Hudson, BD; Hurrell, E; Jazayeri, A; Langmead, CJ; Liptrot, J; Marshall, FH; Mattedi, G; Molloy, C; Morairty, SR; Nathan, PJ; Okrasa, K; Osborne, G; Patel, JC; Perini, F; Phillips, K; Pickworth, M; Robertson, N; Rucktooa, P; Sexton, PM; Shahabi, S; Smith, RT; Tasker, T; Tehan, BG; Teobald, B; Tobin, AB; Vinson, M; Warneck, J; Weir, M, 2021) |
| "Drug development is a high-risk and high failure enterprise, and studies that provide an early read on the pharmacodynamic activity of novel compounds could save time and money, increasing the efficiency of the drug development process." | 2.77 | The scopolamine model as a pharmacodynamic marker in early drug development. ( Abi-Saab, W; Baker, JD; Lenz, RA; Locke, C; Mohler, EG; Rueter, LE; Saltarelli, MD; Wesnes, K, 2012) |
| "The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the quality of life." | 2.55 | Alzheimer's disease in the zebrafish: where can we take it? ( Caramillo, EM; Echevarria, DJ, 2017) |
| "Using Alzheimer's disease as an example, this review employs a networks-based method to assess repeatability of outcomes across species, by intervention and mechanism." | 2.52 | Improving the predictive value of interventional animal models data. ( Zeiss, CJ, 2015) |
| " We found that long-term administration of donepezil, an acetylcholinesterase inhibitor clinically used for the treatment of Alzheimer's disease, promotes the survival of newly-generated neurons in the OB and the DG." | 2.44 | [Neuronal migration in the adult brain]. ( Kaneko, N; Sawamoto, K, 2007) |
| "Donepezil was superior to bromelain in improving locomotor activity." | 1.91 | Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway. ( Abo El-Magd, NF; Eraky, SM; Ramadan, NM, 2023) |
| "Experiments on transgenic mice with an Alzheimer's disease model (APP/PS1) demonstrated that the intranasal administration of liposomes within 21 days resulted in enhanced learning abilities and a reduction in the formation rate of Aβ plaques in the entorhinal cortex and hippocampus of the brain." | 1.91 | Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer's Disease Therapy. ( Belyaev, G; Bushmeleva, K; Gaynanova, G; Petrov, K; Samigullin, D; Sibgatullina, G; Sinyashin, O; Valeeva, F; Vasileva, L; Vyshtakalyuk, A; Zakharova, L; Zueva, I, 2023) |
| "The pharmacokinetic (PK) change in a drug by co-administered herbal products can alter the efficacy and toxicity." | 1.62 | Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. ( Bae, M; Chin, YW; Cho, J; Choi, YH; Han, SY; Kim, ES; Kim, YM; You, BH, 2021) |
| "Treatment with donepezil was administered from the 4th to the 6th month of life." | 1.62 | Donepezil improves vascular function in a mouse model of Alzheimer's disease. ( Antonioli, L; Baldacci, F; Bernardini, N; Blandizzi, C; D'Antongiovanni, V; Duranti, E; Fornai, M; Masi, S; Pellegrini, C; Taddei, S; Virdis, A, 2021) |
| " T-006 improved cognitive ability after long-term administration in two AD mouse models and targeted mitochondrial-related protein alpha-F1-ATP synthase (ATP5A)." | 1.62 | The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease. ( Chen, H; Cheng, J; Guo, B; Huang, C; Su, Z; Sun, Y; Wang, Y; Wu, J; Wu, L; Yang, X; Zhang, G; Zhang, Z; Zhu, Z, 2021) |
| " Donepezil (3 mg/kg; po) and sertraline (10 mg/kg; po) dosing was started from D-8 and continued up to D-32." | 1.62 | Development and treatment of cognitive inflexibility in sub-chronic stress-re-stress (SRS) model of PTSD. ( Krishnamurthy, S; Prajapati, SK, 2021) |
| "The modulatory effects of piperine on drug metabolizing enzymes play an important role in the control of pharmacokinetic and the bioavailability properties of the administered drugs." | 1.62 | The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease. ( Ashrafpoor, M; Esfahani, DE; Nazifi, M; Oryan, S, 2021) |
| "MO reversed Sco-induced memory deficits and brain oxidative stress, along with cholinesterase inhibitory effects, which is an important mechanism in the anti-amnesia effect." | 1.56 | Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches. ( Boiangiu, RS; Brinza, I; Cioanca, O; Erdogan Orhan, I; Eren, G; Ertas, H; Gündüz, E; Hancianu, M; Hritcu, L, 2020) |
| "Donepezil treatment protected rats from renal dysfunction in a dose-dependent manner and through the cholinergic anti-inflammatory pathway." | 1.56 | Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats. ( Fu, X; Ren, H; Song, Z; Sun, G; Wang, J; Wang, P; Yue, Y, 2020) |
| "Donepezil is an acetylcholinesterase inhibitor that is currently used in patients with mild to moderate AD, and has recently been shown to improve cognitive performance in patients with VaD." | 1.56 | Donepezil down-regulates propionylation, 2-hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion-induced vascular dementia rats. ( Chen, C; Ding, Z; Gao, WC; Li, N; Lu, J; Ma, X; Qiao, G; Wang, H; Weng, Z; Wu, C; Xiao, C; Yang, W; Zhang, C; Zheng, CB; Zhu, M, 2020) |
| " After the 15-day treatment, the Morris water maze test, micro-PET(positron-emission tomography), H&E (haematoxylin and eosin) staining, and immunohistochemistry were used to study the differences between donepezil (SAMP8+D), acupuncture (SAMP8+MA), and donepezil combined with acupuncture (SAMP8+D+MA) therapy for the treatment of Alzheimer's disease." | 1.51 | Effects of manual acupuncture combined with donepezil in a mouse model of Alzheimer's disease. ( Jiang, J; Li, Y; Li, Z; Liu, G; Shi, S, 2019) |
| " Considering that vascular dysfunction is a crucial feature of arterial hypertension, we investigated the effects of chronic administration of acetylcholinesterase inhibitors-pyridostigmine or donepezil-on vascular reactivity of spontaneously hypertensive rats (SHR)." | 1.51 | Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats. ( Cau, SBA; Lataro, RM; Mestriner, FL; Salgado, HC; Silva, MAB; Tostes, RCA, 2019) |
| " However, a dose-response study evaluating DON after a controlled cortical impact (CCI) injury in rats did not reveal cognitive benefits." | 1.48 | Systemic administration of donepezil attenuates the efficacy of environmental enrichment on neurobehavioral outcome after experimental traumatic brain injury. ( Bondi, CO; Bou-Abboud, CE; Cheng, JP; Day-Cooney, J; Folweiler, KA; Kline, AE; Leary, JB; Memarzadeh, K; Tehranian-DePasquale, R; Yelleswarapu, NK, 2018) |
| "Donepezil has been reported to have limited Aβ-targeting mechanisms beside its acetylcholine esterase inhibition." | 1.48 | Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease. ( Batarseh, YS; Kaddoumi, A, 2018) |
| "Translational research in Alzheimer's disease (AD) pathology provides evidence that accumulation of amyloid-β and hyperphosphorylated tau, neuropathological hallmarks of AD, is associated with complex disturbances in synaptic and neuronal function leading to oscillatory abnormalities in the neuronal networks that support memory and cognition." | 1.48 | Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats. ( Hajós, M; Horvath, TL; Kelley, C; Stoiljkovic, M, 2018) |
| "Treatment with donepezil or BPCT significantly decreased the prolonged 2nd retention transfer latency and 2nd retention latency time values of the SADM group in the EPM and MWM tests, respectively." | 1.46 | A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats. ( Can, ÖD; Demir Özkay, Ü; Sağlık, BN; Turan, N, 2017) |
| "Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD)." | 1.46 | Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. ( Cui, L; Hattori, S; Hayashi, T; Ikejima, T; Liu, B; Liu, W; Song, X; Tashiro, SI; Ushiki-Kaku, Y; Xu, F; Zhou, B, 2017) |
| "Also, reduction of amyloid plaque burden and gliosis in the cortex and hippocampus was assessed." | 1.46 | The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease. ( Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M, 2017) |
| "The effects of AD-35 on cognitive impairments and neuroinflammatory changes caused by intracerebroventricular injection of Aβ25-35 were studied in rats." | 1.46 | Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease. ( Cai, J; Feng, N; Feng, R; Gong, Y; Li, J; Li, L; Liu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Zhao, X, 2017) |
| "Epileptic seizures are short episodes of abnormal brain electrical activity." | 1.46 | Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. ( Choi, BY; Choi, HC; Hong, DK; Jeong, JH; Kho, AR; Lee, SH; Lee, SY; Song, HK; Suh, SW, 2017) |
| "Furthermore, the effects of UW-MD-71 on memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (DIZ) were tested." | 1.43 | The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats. ( Darras, FH; Decker, M; Khan, N; Nurulain, SM; Saad, A; Sadek, B, 2016) |
| "Treatment with vanillin in different doses and donepezil have significantly ameliorated i." | 1.43 | Protective effect of transient receptor potential vanilloid subtype 1 (TRPV1) modulator, against behavioral, biochemical and structural damage in experimental models of Alzheimer's disease. ( Jayant, S; Sharma, B; Sharma, BM, 2016) |
| "Ferulic acid (FA) acts as a powerful antioxidant against various age-related diseases." | 1.43 | Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model. ( Gao, J; Gao, W; Huo, L; Qu, Z; Yang, H; Zhang, J, 2016) |
| "Memantine is a low-affinity voltage-dependent noncompetitive antagonist at glutamatergic NMDA receptors." | 1.42 | Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil. ( Akishita, M; Ogawa, S; Ota, H; Ouchi, Y, 2015) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| "Donepezil treatment reduced cholesterol accumulation in adult neural stem cells in vitro, and it downregulated the expression of the cholesterol synthesis factors' sterol regulatory element-binding proteins and 3-hydroxy-3-methylglutaryl-CoA reductase in the cerebellum, implying that AChE activity might be associated with cholesterol homeostasis." | 1.40 | Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C. ( Choi, SW; Hong, IS; Kang, I; Kang, KS; Kim, HS; Seo, Y; Shin, Y; Yu, KR, 2014) |
| "Donepezil hydrochloride is an acetylcholinesterase inhibitor (AChEI) currently used for the symptomatic treatment of Alzheimer's disease (AD)." | 1.40 | Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia. ( Cho, KS; Choi, BR; Han, JS; Han, SH; Kim, HY; Kim, JN; Kim, MK; Kim, SY; Kwon, KJ; Lee, EJ; Shin, CY, 2014) |
| "Donepezil is an acetylcholinesterase inhibitor that has been shown previously to improve cognition in healthy non-treatment-seeking smokers." | 1.40 | Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. ( Hayes, MR; Kimmey, BA; Rupprecht, LE; Schmidt, HD, 2014) |
| "Alzheimer's disease is characterized by a progressive decline in cognitive function and involves β-amyloid (Aβ) in its pathogenesis." | 1.39 | Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine. ( Matsuoka, N; Nagakura, A; Shitaka, Y; Yarimizu, J, 2013) |
| "Donepezil was able to fully reverse the effects of biperiden on N50 sensory gating, but had residual effects when combined with scopolamine; i." | 1.39 | Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats. ( Blokland, A; Klinkenberg, I; Sambeth, A, 2013) |
| "Current treatment of Alzheimer's disease rests on cholinergic and anti-glutamatergic substances." | 1.38 | Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease. ( Neumeister, KL; Riepe, MW, 2012) |
| "After carotid stenosis was relieved, the cerebral blood flow values significantly increased, and P300 latency and escape latency in the Morris water-maze were significantly shortened." | 1.37 | Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion. ( Chen, KN; Chun-Qing, Z; Duan, W; Gui, L; Huang, HQ; Zheng, J, 2011) |
| "Treatment with donepezil (1." | 1.37 | Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice. ( Alkam, T; Furukawa-Hibi, Y; Greig, NH; Matsuyama, A; Mizoguchi, H; Moussaoui, S; Nagai, T; Nitta, A; Suzuki, K; Yamada, K; Yu, QS, 2011) |
| "Several mouse models of Alzheimer's disease (AD) with abundant β-amyloid and/or aberrantly phosphorylated tau develop memory impairments." | 1.37 | Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). ( Bussey, TJ; Mattson, MP; Mughal, MR; Romberg, C; Saksida, LM, 2011) |
| "Donepezil is a reversible and noncompetitive cholinesterase inhibitor." | 1.36 | Microglia signaling as a target of donepezil. ( Hwang, H; Hwang, J; Lee, HW; Suk, K, 2010) |
| " Single, parenteral dosing of donepezil (1, 1." | 1.36 | Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. ( Andersen, LM; Bjerrum, OJ; Folkesson, A; Honoré, PH; Kristensen, P, 2010) |
| "Celecoxib/STZ treatments produced a significant loss of learning and memory." | 1.35 | Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil. ( Sharma, B; Singh, M; Singh, N, 2008) |
| "Since acute and chronic administration of the acetylcholinesterase inhibitors, namely donepezil, improves cognitive functions in patients afflicted by mild to moderate dementia and reverses memory deficits in experimental models of learning and memory, it seemed interesting to assess the effects of chronic donepezil treatment on cognitive functions in adult rats with forebrain cholinergic depletion." | 1.35 | Cognitive performances of cholinergically depleted rats following chronic donepezil administration. ( Cutuli, D; De Bartolo, P; Federico, F; Foti, F; Gelfo, F; Mandolesi, L; Petrosini, L, 2009) |
| " In this study, we sought to determine whether long-term administration of donepezil would slow amyloid plaque deposition or confer neuronal protection in a mouse model of AD." | 1.35 | Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease. ( Coughlan, CA; Csernansky, JG; Dong, H; Murphy, KM; Yuede, CM, 2009) |
| " Donepezil was orally given at a dosage of 5 mgxkg(-1)xday(-1)." | 1.35 | Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice. ( Ando, M; Arikawa, M; Handa, T; Kakinuma, Y; Katare, RG; Sasaguri, S; Sato, T; Yamasaki, F, 2009) |
| "Donepezil was given orally to rats subjected to MTBI." | 1.35 | Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury. ( Abe, T; Fujiki, M; Hikawa, T; Ishii, K; Kamida, T; Kobayashi, H; Kubo, T; Sugita, K, 2008) |
| "APP23 mice are a promising model of Alzheimer's disease, expressing several histopathological, cognitive and behavioural hallmarks of the human condition." | 1.33 | Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. ( Abramowski, D; De Deyn, PP; Staufenbiel, M; Van Dam, D, 2005) |
| "54 mg kg-1 D-1 dosage as a positive control drug, DZXYS in 12." | 1.33 | [Protective effect of Danzhi-xiaoyao San on rat brain energy or material metabolism (correction of matebolism) dealt with D-galactose]. ( Cai, DY; Chen, JX; Huang, QF; Sun, LP; Wang, X; Zhang, JJ; Zhang, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 26 (15.48) | 29.6817 |
| 2010's | 103 (61.31) | 24.3611 |
| 2020's | 39 (23.21) | 2.80 |
| Authors | Studies |
|---|---|
| Więckowska, A | 1 |
| Więckowski, K | 1 |
| Bajda, M | 1 |
| Brus, B | 1 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Gobec, S | 1 |
| Filipek, B | 1 |
| Malawska, B | 1 |
| Gurjar, AS | 1 |
| Darekar, MN | 1 |
| Yeong, KY | 1 |
| Ooi, L | 1 |
| Wu, Y | 2 |
| Zhou, Q | 2 |
| Zhang, T | 1 |
| Li, Z | 4 |
| Chen, YP | 1 |
| Zhang, P | 1 |
| Yu, YF | 1 |
| Geng, H | 1 |
| Tian, YJ | 1 |
| Zhang, C | 2 |
| Wang, Y | 8 |
| Chen, JW | 1 |
| Chen, Y | 3 |
| Luo, HB | 2 |
| Gutti, G | 1 |
| Kakarla, R | 1 |
| Kumar, D | 1 |
| Beohar, M | 1 |
| Ganeshpurkar, A | 1 |
| Kumar, A | 2 |
| Krishnamurthy, S | 2 |
| Singh, SK | 1 |
| Sang, Z | 1 |
| Wang, K | 1 |
| Bai, P | 1 |
| Wu, A | 1 |
| Shi, J | 2 |
| Liu, W | 4 |
| Zhu, G | 1 |
| Lan, Y | 1 |
| Chen, Z | 1 |
| Zhao, Y | 2 |
| Qiao, Z | 1 |
| Wang, C | 2 |
| Tan, Z | 1 |
| Singh, YP | 1 |
| Tej, GNVC | 1 |
| Pandey, A | 1 |
| Priya, K | 1 |
| Pandey, P | 1 |
| Shankar, G | 1 |
| Nayak, PK | 1 |
| Rai, G | 1 |
| Chittiboyina, AG | 1 |
| Doerksen, RJ | 1 |
| Vishwakarma, S | 1 |
| Modi, G | 1 |
| Dai, B | 1 |
| Ma, X | 2 |
| Tang, Y | 1 |
| Xu, L | 1 |
| Guo, S | 1 |
| Chen, X | 2 |
| Lu, S | 1 |
| Wang, G | 1 |
| Liu, Y | 2 |
| Huang, Y | 1 |
| Wu, XN | 1 |
| Zheng, D | 1 |
| Guo, L | 1 |
| Li, Q | 2 |
| Xing, S | 1 |
| Liao, Q | 1 |
| Xiong, B | 1 |
| Lu, W | 1 |
| He, S | 1 |
| Feng, F | 1 |
| Sun, H | 1 |
| Bae, M | 1 |
| Han, SY | 1 |
| Kim, ES | 1 |
| You, BH | 1 |
| Kim, YM | 2 |
| Cho, J | 1 |
| Chin, YW | 2 |
| Choi, YH | 1 |
| Kim, J | 1 |
| Lee, HJ | 1 |
| Park, SK | 1 |
| Park, JH | 2 |
| Jeong, HR | 1 |
| Lee, S | 2 |
| Lee, H | 2 |
| Seol, E | 2 |
| Hoe, HS | 2 |
| Pellegrini, C | 1 |
| D'Antongiovanni, V | 1 |
| Fornai, M | 1 |
| Duranti, E | 1 |
| Baldacci, F | 1 |
| Bernardini, N | 1 |
| Taddei, S | 1 |
| Virdis, A | 1 |
| Blandizzi, C | 1 |
| Masi, S | 1 |
| Antonioli, L | 1 |
| Brown, AJH | 1 |
| Bradley, SJ | 1 |
| Marshall, FH | 1 |
| Brown, GA | 1 |
| Bennett, KA | 1 |
| Brown, J | 1 |
| Cansfield, JE | 1 |
| Cross, DM | 1 |
| de Graaf, C | 1 |
| Hudson, BD | 1 |
| Dwomoh, L | 1 |
| Dias, JM | 1 |
| Errey, JC | 1 |
| Hurrell, E | 1 |
| Liptrot, J | 1 |
| Mattedi, G | 1 |
| Molloy, C | 1 |
| Nathan, PJ | 1 |
| Okrasa, K | 1 |
| Osborne, G | 1 |
| Patel, JC | 1 |
| Pickworth, M | 1 |
| Robertson, N | 1 |
| Shahabi, S | 1 |
| Bundgaard, C | 1 |
| Phillips, K | 1 |
| Broad, LM | 1 |
| Goonawardena, AV | 1 |
| Morairty, SR | 1 |
| Browning, M | 1 |
| Perini, F | 1 |
| Dawson, GR | 1 |
| Deakin, JFW | 1 |
| Smith, RT | 1 |
| Sexton, PM | 1 |
| Warneck, J | 1 |
| Vinson, M | 1 |
| Tasker, T | 1 |
| Tehan, BG | 1 |
| Teobald, B | 1 |
| Christopoulos, A | 1 |
| Langmead, CJ | 1 |
| Jazayeri, A | 1 |
| Cooke, RM | 1 |
| Rucktooa, P | 1 |
| Congreve, MS | 1 |
| Weir, M | 1 |
| Tobin, AB | 1 |
| Jiang, J | 2 |
| Liu, H | 2 |
| Wang, Z | 1 |
| Tian, H | 1 |
| Wang, S | 2 |
| Yang, J | 1 |
| Liu, QF | 1 |
| Choi, H | 1 |
| Son, T | 1 |
| Kanmani, S | 1 |
| Kim, SN | 1 |
| Kim, KK | 1 |
| Kim, KW | 1 |
| Koo, BS | 2 |
| Huang, LP | 1 |
| Zhong, XQ | 1 |
| Zhou, XY | 1 |
| Deng, MQ | 1 |
| Wu, MJ | 1 |
| Deng, MZ | 1 |
| Choi, HJ | 1 |
| Jeong, YJ | 1 |
| Hwang, JW | 1 |
| Kim, IW | 1 |
| Cha, BY | 1 |
| Seo, J | 1 |
| Moon, M | 1 |
| Jo, JK | 1 |
| Lee, G | 1 |
| Nguyen, CD | 1 |
| Park, SE | 1 |
| Kim, EJ | 2 |
| Kim, HW | 1 |
| Seo, SH | 1 |
| Cho, KM | 1 |
| Kwon, SJ | 1 |
| Kim, JH | 1 |
| Son, HS | 1 |
| Taheri, P | 1 |
| Yaghmaei, P | 1 |
| Hajebrahimi, Z | 1 |
| Parivar, K | 1 |
| Dos Santos, A | 3 |
| Teixeira, FC | 3 |
| da Silva, DS | 3 |
| Veleda, TA | 3 |
| de Mello, JE | 3 |
| Luduvico, KP | 3 |
| Tavares, RG | 3 |
| Stefanello, FM | 3 |
| Cunico, W | 3 |
| Spanevello, RM | 3 |
| Eraky, SM | 3 |
| Ramadan, NM | 3 |
| Abo El-Magd, NF | 3 |
| Huang, H | 1 |
| Fang, C | 1 |
| Niu, H | 1 |
| Yin, X | 1 |
| Ruan, J | 1 |
| Wei, M | 1 |
| Zhou, Y | 1 |
| Vasileva, L | 1 |
| Gaynanova, G | 1 |
| Valeeva, F | 1 |
| Belyaev, G | 1 |
| Zueva, I | 1 |
| Bushmeleva, K | 1 |
| Sibgatullina, G | 1 |
| Samigullin, D | 1 |
| Vyshtakalyuk, A | 1 |
| Petrov, K | 1 |
| Zakharova, L | 1 |
| Sinyashin, O | 1 |
| Anoush, M | 1 |
| Bijani, S | 1 |
| Moslemifar, F | 1 |
| Jahanpour, F | 1 |
| Kalantari-Hesari, A | 1 |
| Hosseini, MJ | 1 |
| Lee, SY | 2 |
| Cho, HY | 1 |
| Oh, JP | 1 |
| Park, J | 1 |
| Bae, SH | 1 |
| Park, H | 1 |
| Lee, JH | 2 |
| Wong, JC | 1 |
| Thelin, JT | 1 |
| Escayg, A | 1 |
| Swartzwelder, HS | 1 |
| Healey, KL | 1 |
| Dubester, K | 1 |
| Miller, KM | 1 |
| Crews, FT | 1 |
| Pang, J | 1 |
| Hou, J | 1 |
| Zhou, Z | 1 |
| Ren, M | 1 |
| Mo, Y | 1 |
| Yang, G | 2 |
| Qu, Z | 2 |
| Hu, Y | 1 |
| Potasiewicz, A | 1 |
| Krawczyk, M | 1 |
| Gzielo, K | 1 |
| Popik, P | 1 |
| Nikiforuk, A | 1 |
| Qi, Y | 1 |
| Jing, H | 1 |
| Cheng, X | 1 |
| Yan, T | 1 |
| Xiao, F | 1 |
| Wu, B | 2 |
| Bi, K | 1 |
| Jia, Y | 2 |
| Boiangiu, RS | 1 |
| Brinza, I | 1 |
| Hancianu, M | 1 |
| Erdogan Orhan, I | 1 |
| Eren, G | 1 |
| Gündüz, E | 1 |
| Ertas, H | 1 |
| Hritcu, L | 1 |
| Cioanca, O | 1 |
| Wang, H | 2 |
| Lu, J | 1 |
| Gao, WC | 1 |
| Li, N | 1 |
| Ding, Z | 1 |
| Wu, C | 1 |
| Zhu, M | 1 |
| Qiao, G | 1 |
| Xiao, C | 1 |
| Chen, C | 1 |
| Weng, Z | 1 |
| Yang, W | 1 |
| Zheng, CB | 1 |
| Cavalcante, GL | 1 |
| Ferreira, FN | 1 |
| da Silva, MTB | 1 |
| Soriano, RN | 1 |
| Filho, ALMM | 1 |
| Arcanjo, DDR | 1 |
| Sabino, JPJ | 1 |
| Jin, N | 1 |
| Ziyatdinova, S | 1 |
| Gureviciene, I | 1 |
| Tanila, H | 1 |
| Giacomini, AC | 1 |
| Bueno, BW | 1 |
| Marcon, L | 1 |
| Scolari, N | 1 |
| Genario, R | 1 |
| Demin, KA | 1 |
| Kolesnikova, TO | 1 |
| Kalueff, AV | 1 |
| de Abreu, MS | 1 |
| Li, M | 2 |
| Zheng, C | 2 |
| Kawada, T | 2 |
| Inagaki, M | 2 |
| Uemura, K | 2 |
| Akiyama, T | 1 |
| Sugimachi, M | 2 |
| Knakker, B | 1 |
| Oláh, V | 1 |
| Trunk, A | 1 |
| Lendvai, B | 1 |
| Lévay, G | 1 |
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| Semwal, BC | 1 |
| Garabadu, D | 1 |
| Ongnok, B | 1 |
| Khuanjing, T | 1 |
| Chunchai, T | 1 |
| Kerdphoo, S | 1 |
| Jaiwongkam, T | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Sun, G | 1 |
| Wang, J | 3 |
| Wang, P | 3 |
| Ren, H | 1 |
| Yue, Y | 1 |
| Song, Z | 1 |
| Fu, X | 1 |
| Nazifi, M | 1 |
| Oryan, S | 1 |
| Esfahani, DE | 1 |
| Ashrafpoor, M | 1 |
| Zhao, J | 2 |
| Li, K | 1 |
| Li, D | 1 |
| Wang, Q | 3 |
| Xie, S | 1 |
| Zuo, Z | 1 |
| Prajapati, SK | 1 |
| Zhang, G | 3 |
| Wu, J | 1 |
| Huang, C | 1 |
| Cheng, J | 1 |
| Su, Z | 1 |
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| Yang, X | 1 |
| Guo, B | 1 |
| Wu, L | 1 |
| Zhang, Z | 2 |
| Chen, H | 1 |
| Sun, Y | 1 |
| Vasilopoulou, F | 1 |
| Rodríguez-Arévalo, S | 1 |
| Bagán, A | 1 |
| Escolano, C | 1 |
| Griñán-Ferré, C | 1 |
| Pallàs, M | 1 |
| Nisha, SA | 1 |
| Devi, KP | 1 |
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| Hill, MD | 1 |
| Godley, A | 1 |
| Goetghebeur, PJ | 1 |
| Kaur, R | 1 |
| Singh, V | 1 |
| Shri, R | 1 |
| Song, X | 1 |
| Liu, B | 2 |
| Cui, L | 1 |
| Zhou, B | 1 |
| Xu, F | 1 |
| Hayashi, T | 1 |
| Hattori, S | 1 |
| Ushiki-Kaku, Y | 1 |
| Tashiro, SI | 1 |
| Ikejima, T | 1 |
| Rahman, A | 1 |
| Lamberty, Y | 1 |
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| Cella, M | 1 |
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| Bordet, R | 1 |
| Richardson, J | 1 |
| Pifferi, F | 1 |
| Aujard, F | 1 |
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| Lee, SH | 2 |
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| Song, HK | 1 |
| Choi, HC | 1 |
| Suh, SW | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Efficacy of Chinese Traditional Medicine Smart Soup in Cognition and Behavior Regulation in Alzheimer's Disease"[NCT05538507] | Phase 2 | 180 participants (Anticipated) | Interventional | 2022-06-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for donepezil and Disease Models, Animal
| Article | Year |
|---|---|
Improving the predictive value of interventional animal models data.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Data Mining; Databases, Factual; Disease Mode | 2015 |
Psychopharmacological Studies in Mice.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dopamine; | 2016 |
Alzheimer's disease in the zebrafish: where can we take it?
Topics: Alzheimer Disease; Animals; Dementia; Disease Models, Animal; Donepezil; Humans; Indans; Memantine; | 2017 |
[Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse].
Topics: Acetylcholine; Amyloid; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil | 2008 |
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Cholinergic Agents; Cholinesterase Inhi | 2009 |
[Management of Alzheimer disease].
Topics: Aged; Alzheimer Disease; Animals; Antipsychotic Agents; Caregivers; Case Management; Cholinesterase | 2007 |
[Neuronal migration in the adult brain].
Topics: Adult; Alzheimer Disease; Animals; Brain; Cell Differentiation; Cell Movement; Cell Survival; Cerebr | 2007 |
2 trials available for donepezil and Disease Models, Animal
| Article | Year |
|---|---|
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acid Sequence; Animals; Blood Pressure; CHO | 2021 |
The scopolamine model as a pharmacodynamic marker in early drug development.
Topics: Adult; Animals; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, | 2012 |
159 other studies available for donepezil and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Binding Sites; Catalytic Domain; | 2019 |
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amnesia; Amyloid beta-Peptides; Animals; Butyrylcho | 2019 |
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Cell Line; Cell Survival; Disease Models, | 2020 |
Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Antioxidants; Biological Pro | 2020 |
Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Calcium Channel Blockers; Calcium Signaling; Dantrolene; Disease Models, | 2021 |
Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Administration, Oral; Animals; Behavior, Animal; Bindi | 2020 |
Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection.
Topics: Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cell Survival; Cholinesterase | 2021 |
Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Donepezil; Garcinia mangostana; Mice; Wat | 2021 |
Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Cholinesterase Inhib | 2021 |
Donepezil improves vascular function in a mouse model of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cardiovascular Diseases; Cholinesterase Inhibitors; Cogni | 2021 |
Effects of electroacupuncture on DNA methylation of the TREM2 gene in senescence-accelerated mouse prone 8 mice.
Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Disease Models, Animal; DNA Methylation; Donepezil; El | 2022 |
Co-Treatment with the Herbal Medicine SIP3 and Donepezil Improves Memory and Depression in the Mouse Model of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Depression; Diseas | 2022 |
[Galangin alleviates learning and memory impairments in APP/PS1 double- transgenic mice by regulating Akt/MEF2D/Beclin-1 signaling pathway].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyl | 2022 |
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Donepezil; Mice; Mice, Tr | 2022 |
Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Disease Models, Ani | 2022 |
Neuroprotective effects of nerolidol against Alzheimer's disease in Wistar rats.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Disease | 2022 |
Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Disease M | 2023 |
Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Disease M | 2023 |
Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Disease M | 2023 |
Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: Comparison with donepezil drug.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Cholinesterase Inhibitors; Disease M | 2023 |
Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway.
Topics: Aluminum; Aluminum Chloride; Alzheimer Disease; Animals; Bromelains; Cell Cycle Proteins; Disease Mo | 2023 |
Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway.
Topics: Aluminum; Aluminum Chloride; Alzheimer Disease; Animals; Bromelains; Cell Cycle Proteins; Disease Mo | 2023 |
Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway.
Topics: Aluminum; Aluminum Chloride; Alzheimer Disease; Animals; Bromelains; Cell Cycle Proteins; Disease Mo | 2023 |
Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway.
Topics: Aluminum; Aluminum Chloride; Alzheimer Disease; Animals; Bromelains; Cell Cycle Proteins; Disease Mo | 2023 |
Effects of donepezil treatment on plasma and urine metabolites in amyloid beta-induced Alzheimer's disease rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Donepezil; Fatty Acids; R | 2023 |
Mitochondria-Targeted Delivery Strategy of Dual-Loaded Liposomes for Alzheimer's Disease Therapy.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Donepezil; Liposomes; Mice; Mice, Transge | 2023 |
Edaravone Improves Streptozotocin-Induced Memory Impairment via Alleviation of Behavioral Dysfunction, Oxidative Stress, Inflammation, and Histopathological Parameters.
Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Donepezil; Edaravone; Inflammation | 2023 |
Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Donepezil; HeLa | 2023 |
Donepezil increases resistance to induced seizures in a mouse model of Dravet syndrome.
Topics: Animals; Disease Models, Animal; Donepezil; Epilepsies, Myoclonic; Male; Mice; Mutation; NAV1.1 Volt | 2019 |
Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil.
Topics: Acetylation; Animals; Cell Death; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Donepezil | 2019 |
Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginase; Brain-Derived Neurotrophic Fac | 2020 |
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Choliner | 2020 |
Alpinia oxyphylla-Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway.
Topics: Alpinia; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition Disorders; Cy | 2020 |
Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior Rating Scale; Brain; Butyrylcholinest | 2020 |
Donepezil down-regulates propionylation, 2-hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion-induced vascular dementia rats.
Topics: Animals; Brain; Carotid Artery, Common; Cognition; Dementia, Vascular; Disease Models, Animal; Donep | 2020 |
Acetylcholinesterase inhibition prevents alterations in cardiovascular autonomic control and gastric motility in L-NAME-induced hypertensive rats.
Topics: Acetylcholinesterase; Animals; Arterial Pressure; Autonomic Nervous System; Baroreflex; Cardiovascul | 2020 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis | 2020 |
An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Fe | 2020 |
Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Cholinesterase Inhibito | 2021 |
Delay-dependent cholinergic modulation of visual short-term memory in rhesus macaques.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Donepezil; M | 2021 |
5-N-ethyl Carboxamidoadenosine Stimulates Adenosine-2b Receptor-Mediated Mitogen-Activated Protein Kinase Pathway to Improve Brain Mitochondrial Function in Amyloid Beta-Induced Cognitive Deficit Mice.
Topics: Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Alzheimer Disease; Amyloid beta-P | 2020 |
Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia/reperfusion injury.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain Injuries; Disease Mode | 2021 |
Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Cholinesterase Inhibitors; Disease Models, A | 2020 |
The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Avoidance Learning; Benzodioxoles; Cytochrome P-450 Enzyme In | 2021 |
Enhanced anti-amnestic effect of donepezil by Ginkgo biloba extract (EGb 761) via further improvement in pro-cholinergic and antioxidative activities.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Cell Line; Cholinergi | 2021 |
Development and treatment of cognitive inflexibility in sub-chronic stress-re-stress (SRS) model of PTSD.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Done | 2021 |
The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Autophagy; Autophagy-Related Protein-1 H | 2021 |
Disease-modifying treatment with I
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Donepezil; Female; Imidaz | 2021 |
Gelidiella acerosa protects against Aβ 25-35-induced toxicity and memory impairment in Swiss Albino mice: an in vivo report.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2017 |
Spatial recognition test: A novel cognition task for assessing topographical memory in mice.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Donepezil; Indans; Levetiracetam; Mal | 2017 |
Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Behavior, Animal; Biphenyl | 2017 |
Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Autophagy; Brain-Derived Neurotrophic Fa | 2017 |
Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus).
Topics: Aging; Alzheimer Disease; Animals; Cheirogaleidae; Disease Models, Animal; Donepezil; Indans; Male; | 2017 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administrati | 2017 |
Cognitive enhancing and antioxidant effects of tetrahydroxystilbene glucoside in Aβ1-42-induced neurodegeneration in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cerebral Cortex; Disease Models, An | 2018 |
Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Animals; Biomarkers; Caspase 12; Cerebral Cortex; | 2018 |
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Benzothiazol | 2017 |
Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Benzoxazines; | 2018 |
Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer's disease.
Topics: Acetylcholine; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; | 2018 |
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A | 2018 |
Systemic administration of donepezil attenuates the efficacy of environmental enrichment on neurobehavioral outcome after experimental traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Cognition Disorders; Dise | 2018 |
Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possible neurotransmitters and neuroinflammatory mechanism.
Topics: Acetylcholinesterase; Animals; Betulinic Acid; Cognitive Dysfunction; Disease Models, Animal; Donepe | 2018 |
Possible mechanism of Vitis vinifera L. flavones on neurotransmitters, synaptic transmission and related learning and memory in Alzheimer model rats.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derive | 2018 |
Calcineurin Inhibition and Protein Kinase A Activation Limits Cognitive Dysfunction and Histopathological Damage in a Model of Dementia of the Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Brain; Calcineurin; Calcineurin Inhibitors; | 2018 |
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Brain; Choice Behavior; Cytokines; Disease Mo | 2018 |
The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia.
Topics: Animals; Avoidance Learning; Disease Models, Animal; Donepezil; Excitatory Amino Acid Antagonists; M | 2018 |
Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Do | 2018 |
Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment.
Topics: Animals; Cognitive Dysfunction; Diosmin; Disease Models, Animal; Donepezil; Hippocampus; Long-Term P | 2018 |
Jobelyn Attenuates Oxidative Stress and Improves Memory Performance in Mice Exposed to Anoxic Stress.
Topics: Animals; Biomarkers; Brain; Dietary Supplements; Disease Models, Animal; Donepezil; Glutathione; Hum | 2019 |
Reassembly of native components with donepezil to execute dual-missions in Alzheimer's disease therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoprotein A-I; Blood-Brain Barrier; Cell Lin | 2019 |
Effects of manual acupuncture combined with donepezil in a mouse model of Alzheimer's disease.
Topics: Acupuncture Therapy; Alzheimer Disease; Animals; Brain; Combined Modality Therapy; Disease Models, A | 2019 |
Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats.
Topics: Acetylcholinesterase; Animals; Antihypertensive Agents; Arterial Pressure; Cholinesterase Inhibitors | 2019 |
Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Cholinesterase Inhibitors; Disease Models, Anim | 2013 |
Effects of the adenosine A2A antagonist istradefylline on cognitive performance in rats with a 6-OHDA lesion in prefrontal cortex.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cognition; Cognition Disorders; Disease Models, Animal; | 2013 |
Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cholineste | 2013 |
Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism.
Topics: Acetylcholine; Animals; Autistic Disorder; Caudate Nucleus; Cholinesterase Inhibitors; Cognition Dis | 2014 |
Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.
Topics: Adult Stem Cells; Animals; ATP-Binding Cassette Transporters; Cell Survival; Cells, Cultured; Cerebe | 2014 |
Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage.
Topics: Acetylcholine; Animals; Animals, Outbred Strains; Astrocytes; Blood Glucose; Brain Ischemia; Choline | 2014 |
Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer's disease-like rat model: relevance for amyloid deposition and central neurotransmitter function.
Topics: Alzheimer Disease; Amyloid; Animals; Brain; Brain Chemistry; Cistanche; Disease Models, Animal; Done | 2014 |
Hippocampal P3-like auditory event-related potentials are disrupted in a rat model of cholinergic degeneration in Alzheimer's disease: reversal by donepezil treatment.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Auditory Perception; CA1 Region, Hippocampal; Ch | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal | 2014 |
Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Aza Co | 2014 |
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Brain; Cell Survival; Cogniti | 2015 |
Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
Topics: Acetylcholinesterase; Animals; Autistic Disorder; Behavior, Animal; Blotting, Western; Cells, Cultur | 2014 |
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cholinesterase Inhibitors; Chronic Disease; Diseas | 2014 |
Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Cholinergic Antagonists; Cholin | 2016 |
Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia.
Topics: Animals; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Dentate Gyrus; Disease Models, An | 2014 |
Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments.
Topics: 1-Butanol; Alpinia; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Avoidance | 2015 |
Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations.
Topics: Adipose Tissue; Alzheimer Disease; Animals; Cell Movement; Cells, Cultured; Cognition Disorders; Cyt | 2016 |
The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Brain; Disea | 2015 |
Donepezil rescues spatial learning and memory deficits following traumatic brain injury independent of its effects on neurogenesis.
Topics: Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Donepezil; Female; Ganciclovir; Inda | 2015 |
Donepezil attenuates Aβ-associated mitochondrial dysfunction and reduces mitochondrial Aβ accumulation in vivo and in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cholineste | 2015 |
Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.
Topics: Alzheimer Disease; Aminoquinolines; Amyloid beta-Protein Precursor; Animals; Animals, Genetically Mo | 2015 |
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model.
Topics: Aging; Alzheimer Disease; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, An | 2015 |
Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice.
Topics: Acetylcholinesterase; Animals; Anticholesteremic Agents; Antioxidants; Behavior, Animal; Biomarkers; | 2015 |
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments.
Topics: Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug S | 2016 |
Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil.
Topics: Aging; Alzheimer Disease; Animals; beta-Galactosidase; Cholinesterase Inhibitors; Cognition; Disease | 2015 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizo | 2016 |
Efficacy of Donepezil for Cognitive Impairments in Familial Hypercholesterolemia: Preclinical Proof of Concept.
Topics: Animals; Cholinesterase Inhibitors; Cognition Disorders; Discrimination, Psychological; Disease Mode | 2015 |
Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Cholinesterase Inhibitors; Cognitive Dysfunction; Depress | 2016 |
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cholinergic Antagonists; Cholinesterase Inhibi | 2016 |
Protective effect of transient receptor potential vanilloid subtype 1 (TRPV1) modulator, against behavioral, biochemical and structural damage in experimental models of Alzheimer's disease.
Topics: Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Benzaldehydes; Brain; Chlorides; | 2016 |
Neuroprotective effects of Danggui-Jakyak-San on rat stroke model through antioxidant/antiapoptotic pathway.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Biomarkers; Caspase 3; Cerebral Cortex; Cholines | 2016 |
Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Brain; Caspase 3; Coumaric Acids; Disease Models | 2016 |
Cholinesterase inhibitors, donepezil and rivastigmine, attenuate spatial memory and cognitive flexibility impairment induced by acute ethanol in the Barnes maze task in rats.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models | 2016 |
Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepez | 2016 |
PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain.
Topics: Animals; Antineoplastic Agents; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Donep | 2016 |
Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Disease Models, Animal; Donepe | 2016 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Glios | 2017 |
Cholinergic activation affects the acute and chronic antinociceptive effects of morphine.
Topics: Acetylcholine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Cholinesterase I | 2017 |
Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Line, Tumor; Cholinestera | 2017 |
Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Disease Models, Animal | 2009 |
Cognitive performances of cholinergically depleted rats following chronic donepezil administration.
Topics: Acetylcholine; Analysis of Variance; Animals; Antibodies, Monoclonal; Behavior, Animal; Cholinestera | 2009 |
GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, D | 2009 |
Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Choli | 2009 |
Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Donepezil; Heart Failure; Indans; Male; Mice; Pi | 2009 |
Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.
Topics: Animals; Brain; Calcium Signaling; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Done | 2010 |
Microglia signaling as a target of donepezil.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cells, Cultured; Cocu | 2010 |
Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Donepezil; Humans; Indans; | 2010 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; D | 2012 |
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; | 2011 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |
Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).
Topics: Alzheimer Disease; Animals; Attention; Conditioning, Operant; Disease Models, Animal; Donepezil; Hum | 2011 |
[Effects of early intervention with Huannao Yicong formula effective components on behavior and cholinergic system of β-amyloid precursor protein transgenic mice].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinergic Agents; Di | 2011 |
Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice.
Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Cognition Disorders; Conditioning, Psycholo | 2011 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhi | 2011 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase | 2011 |
Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion.
Topics: Acetylcholine; Acoustic Stimulation; Analysis of Variance; Animals; Biogenic Monoamines; Brain Ische | 2011 |
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Behavi | 2011 |
Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses.
Topics: Animals; Animals, Outbred Strains; Cell Line, Tumor; Cerebral Cortex; Cholinesterase Inhibitors; Dis | 2011 |
Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition Disorders; | 2011 |
Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Butyrylcholinesterase; Cholinesterase Inhibito | 2011 |
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cognition D | 2012 |
Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Syner | 2012 |
Effects of Gossypium herbaceam extract administration on the learning and memory function in the naturally aged rats: neuronal niche improvement.
Topics: Aging; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotroph | 2012 |
Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Di | 2012 |
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2012 |
The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzylidene Compounds; Cholinest | 2013 |
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Donepezil; Drug | 2012 |
Administration of donepezil does not rescue galanin-induced spatial learning deficits.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Donepezil; Galanin; Indans; Learning Disabili | 2012 |
Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Biperiden; Cholinergic Neurons; Cholinesterase Inhibit | 2013 |
Expression of APP, BACE1, AChE and ChAT in an AD model in rats and the effect of donepezil hydrochloride treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein S | 2012 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Anima | 2013 |
Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; C | 2014 |
Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine.
Topics: Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cyclic AMP Response Element-Binding Pr | 2013 |
Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Cognition; Di | 2005 |
Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinesterase Inhibit | 2005 |
[Protective effect of Danzhi-xiaoyao San on rat brain energy or material metabolism (correction of matebolism) dealt with D-galactose].
Topics: Aldehyde Reductase; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, An | 2005 |
Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester.
Topics: Acetylcholine; Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Cognition Disorders | 2007 |
Effects of galantamine and donepezil on active and passive avoidance tests in rats with induced hypoxia.
Topics: Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Resp | 2006 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; C | 2007 |
Donepezil induces a cholinergic sprouting in basocortical degeneration.
Topics: Acetylcholine; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Cholinergic Fi | 2007 |
Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease.
Topics: Amyloid beta-Protein Precursor; Animals; Cognition; Disease Models, Animal; Donepezil; Dose-Response | 2008 |
Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cholines | 2008 |
Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil.
Topics: Acetylcholinesterase; Administration, Oral; Alzheimer Disease; Animals; Brain; Celecoxib; Disease Mo | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezi | 2008 |
Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Choice Behavior; Choline | 2008 |
Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury.
Topics: Animals; Brain; Brain Concussion; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; | 2008 |
Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Association Learning; Cognition; Disease Models, | 2008 |
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.
Topics: Alzheimer Disease; Animals; Brain Infarction; Brain Ischemia; Cell Death; Cholinesterase Inhibitors; | 2002 |