donepezil has been researched along with Demyelinating Diseases in 2 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Donepezil is a drug that has been used to treat AD safely for many years; our findings suggest that it might be repurposed to treat CNS demyelinating diseases such as MS by promoting OPC to OL differentiation and remyelination." | 1.51 | Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination. ( Cui, X; Fang, JH; Guo, YE; Shi, CJ; Suo, N; Xie, X; Zhang, R, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kapoor, T | 1 |
| Mehan, S | 1 |
| Suri, M | 1 |
| Sharma, N | 1 |
| Kumar, N | 1 |
| Narula, AS | 1 |
| Alshammari, A | 1 |
| Alasmari, AF | 1 |
| Alharbi, M | 1 |
| Assiri, MA | 1 |
| Kalfin, R | 1 |
| Cui, X | 1 |
| Guo, YE | 1 |
| Fang, JH | 1 |
| Shi, CJ | 1 |
| Suo, N | 1 |
| Zhang, R | 1 |
| Xie, X | 1 |
2 other studies available for donepezil and Demyelinating Diseases
| Article | Year |
|---|---|
Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cytokines; Demyelinating Diseases; Donepezil; Ethidium; Fingo | 2022 |
Donepezil, a drug for Alzheimer's disease, promotes oligodendrocyte generation and remyelination.
Topics: Animals; Cell Differentiation; Corpus Callosum; Cuprizone; Demyelinating Diseases; Donepezil; Drug R | 2019 |