donepezil and Delirium of Mixed Origin studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Research Excerpts

Excerpt	Relevance	Reference
"To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair."	9.15	Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. ( Appleton, P; Davis, RB; Marcantonio, ER; Palihnich, K, 2011)
"This was a pilot, phase 2a study to assess methodological feasibility and the safety and efficacy of donepezil in preventing postoperative delirium after elective total hip replacement surgery in older people without pre-existing dementia."	9.12	A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. ( Blanchard, MR; Blizard, R; Bruce, A; Garlick, N; Ndhlovu, PN; Raven, PR; Ritchie, CW; Sampson, EL; Vallance, A; Watts, J, 2007)
"This pilot study was unable to demonstrate a benefit for donepezil in preventing or treating delirium in a relatively young and cognitively-intact group of elderly patients undergoing elective orthopedic surgery."	9.11	Donepezil in the prevention and treatment of post-surgical delirium. ( Fingeroth, R; Garb, JL; Krushell, R; Laki, A; Liptzin, B, 2005)
"We utilized the Medical Information Mart for Intensive Care III (MIMIC-III) database to determine whether pre-hospital donepezil use was associated with improved outcomes during critical illness in dementia patients."	8.31	Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium. ( Lee, S; Lieberman, OJ; Zabinski, J, 2023)
"A severe intractable delirium caused by the basal forebrain vascular lesion and its dramatic recovery after donepezil administration were reported."	7.72	Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil. ( Higashima, M; Kidani, T; Kobayashi, K; Koshino, Y; Mutou, K; Tachibana, O; Yamashita, J, 2004)
"When donepezil was re-prescribed, the delirium resolved and the patient's mental state stabilized."	5.38	Withdrawal syndrome after donepezil cessation in a patient with dementia. ( Bidzan, L; Bidzan, M, 2012)
"Delirium is a common complication of dementia and may produce considerable morbidity."	5.30	Donepezil improves symptoms of delirium in dementia: implications for future research. ( Burke, WJ; Roccaforte, WH; Wengel, SP, 1998)
"To determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair."	5.15	Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. ( Appleton, P; Davis, RB; Marcantonio, ER; Palihnich, K, 2011)
"This was a pilot, phase 2a study to assess methodological feasibility and the safety and efficacy of donepezil in preventing postoperative delirium after elective total hip replacement surgery in older people without pre-existing dementia."	5.12	A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. ( Blanchard, MR; Blizard, R; Bruce, A; Garlick, N; Ndhlovu, PN; Raven, PR; Ritchie, CW; Sampson, EL; Vallance, A; Watts, J, 2007)
"This pilot study was unable to demonstrate a benefit for donepezil in preventing or treating delirium in a relatively young and cognitively-intact group of elderly patients undergoing elective orthopedic surgery."	5.11	Donepezil in the prevention and treatment of post-surgical delirium. ( Fingeroth, R; Garb, JL; Krushell, R; Laki, A; Liptzin, B, 2005)
"There is currently no evidence from controlled trials that donepezil is effective in the treatment of delirium."	4.84	Cholinesterase inhibitors for delirium. ( Burns, A; Karim, S; Overshott, R, 2008)
"We utilized the Medical Information Mart for Intensive Care III (MIMIC-III) database to determine whether pre-hospital donepezil use was associated with improved outcomes during critical illness in dementia patients."	4.31	Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium. ( Lee, S; Lieberman, OJ; Zabinski, J, 2023)
"We present a case of delirium due to amitriptyline overdose, which resolved rapidly following initiation of the cholinesterase inhibitor donepezil."	3.72	Donepezil for anticholinergic drug intoxication: a case report. ( Aksu, H; Elbi, H; Noyan, MA, 2003)
"A severe intractable delirium caused by the basal forebrain vascular lesion and its dramatic recovery after donepezil administration were reported."	3.72	Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil. ( Higashima, M; Kidani, T; Kobayashi, K; Koshino, Y; Mutou, K; Tachibana, O; Yamashita, J, 2004)
"Delirium is very common in the elderly."	2.44	[Delirium]. ( Derouesné, C; Lacomblez, L, 2007)
"Delirium is a common mental disorder with serious adverse outcomes in hospitalised patients."	2.44	Interventions for preventing delirium in hospitalised patients. ( Britton, AM; Holmes, J; Siddiqi, N; Stockdale, R, 2007)
"When donepezil was re-prescribed, the delirium resolved and the patient's mental state stabilized."	1.38	Withdrawal syndrome after donepezil cessation in a patient with dementia. ( Bidzan, L; Bidzan, M, 2012)
"However, interictal delirium is uncommon in absence of risk factors."	1.38	Delayed onset and prolonged interictal delirium following electroconvulsive therapy. ( Praharaj, SK; Selvaraj, AG, 2012)
"Delirium is a common complication of dementia and may produce considerable morbidity."	1.30	Donepezil improves symptoms of delirium in dementia: implications for future research. ( Burke, WJ; Roccaforte, WH; Wengel, SP, 1998)

Research

Studies (21)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Change From Baseline and MDAS Scores Over Time

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (14.29)	18.2507
2000's	9 (42.86)	29.6817
2010's	8 (38.10)	24.3611
2020's	1 (4.76)	2.80

Authors	Studies
Lieberman, OJ	1
Lee, S	1
Zabinski, J	1
Tung, EE	1
Litin, SC	1
Bundrick, JB	1
Naharci, MI	1
Takamiya, A	1
Sawada, K	1
Hirano, J	1
Mimura, M	1
Kishimoto, T	1
Stocker, L	1
Jellestad, L	1
Jenewein, J	1
Boettger, S	1
Kinoshita, T	1
Hanabusa, H	1
Marcantonio, ER	1
Palihnich, K	1
Appleton, P	1
Davis, RB	1
Bidzan, L	1
Bidzan, M	1
Selvaraj, AG	1
Praharaj, SK	1
Noyan, MA	1
Elbi, H	1
Aksu, H	1
Kobayashi, K	1
Higashima, M	1
Mutou, K	1
Kidani, T	1
Tachibana, O	1
Yamashita, J	1
Koshino, Y	1
Liptzin, B	1
Laki, A	1
Garb, JL	1
Fingeroth, R	1
Krushell, R	1
Sampson, EL	1
Raven, PR	1
Ndhlovu, PN	1
Vallance, A	1
Garlick, N	1
Watts, J	1
Blanchard, MR	1
Bruce, A	1
Blizard, R	1
Ritchie, CW	1
Derouesné, C	1
Lacomblez, L	1
Logan, CJ	1
Stewart, JT	1
Siddiqi, N	1
Stockdale, R	1
Britton, AM	1
Holmes, J	1
Overshott, R	1
Karim, S	1
Burns, A	1
Kaufer, DI	1
Catt, KE	1
Lopez, OL	1
DeKosky, ST	1
Wengel, SP	2
Roccaforte, WH	2
Burke, WJ	2
Kawashima, T	1
Yamada, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period[NCT00586196]	Phase 2	16 participants (Actual)	Interventional	2007-01-31	Completed
Usefulness of Bright Light Therapy in the Prevention of Delirium in Patients Undergoing Hematopoietic Stem Cell Transplant (HSCT)[NCT01700816]		40 participants (Actual)	Interventional	2012-10-31	Terminated (stopped due to Low incidence of delirium.)
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 3-year Follow-up of a Randomized Controlled Trial[NCT02809937]	Phase 4	700 participants (Actual)	Interventional	2011-05-31	Completed
Pilot Study of a Multicomponent Nurse Intervention to Reduce the Incidence and Severity of Delirium in Hospitalized Older Adults: MID-Nurse-P[NCT02558777]		50 participants (Actual)	Interventional	2013-10-31	Completed
The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172]	Phase 2	60 participants (Actual)	Interventional	2014-12-31	Completed
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 5-year Follow-up of a Randomized Controlled Trial[NCT03436472]		700 participants (Actual)	Interventional	2017-06-01	Completed
Namenda as Prevention for Post-Operative Delirium[NCT00303433]	Phase 4	30 participants	Interventional	2006-03-31	Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Measures severity of 10 delirium symptoms items (0 not present, 1 mild, 2 moderate, 3 severe) yielding a total score of 0 to 30, with 30 most severe. (NCT00586196)
Timeframe: Baseline, hospital discharge, weeks 2, 4 and 6

Percentage of Participants With Delirium Using the CAM Over Time

Intervention	units on a scale (Mean)
	Baseline	Change at Hospital Discharge	Change at Week 2	Change at week 4	Change at week 6
Donepezil : 5 mg Each Day for 30 Days	6.3	1.3	-0.1	-1.2	-0.6
Placebo : Encapsulated Cornstarch	8.4	1.6	-2.2	-2.0	-2.0

Confusion Assessment Method (CAM)-Measure of the presence or absence of delirium. Requires 1) acute change with fluctuating course, 2) inattention, and either 3) disorganized thinking or 4) altered level of consciousness. (NCT00586196)
Timeframe: Baseline, hospital interviews, weeks 2, 4 and 6

Hematocrit (HCT)

Intervention	percentage of participants (Number)
	basline	hospital interviews	Week 2	week 4	week 6
Donepezil : 5 mg Each Day for 30 Days	14	64	43	17	50
Placebo : Encapsulated Cornstarch	44	64	43	43	50

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT. (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Hemoglobin (HGB)

Intervention	volume percentage (vol%) of red blood ce (Median)
Bright Light Therapy	28.20
Sham Light	26.70

Hospital Length of Stay

Intervention	g/dl (Median)
Bright Light Therapy	9.70
Sham Light	9.55

(NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Number of Participants Who Developed Delirium Based on Meeting Criteria on the Delirium Rating Scale and/or Memorial Delirium Assessment Scale

Intervention	days (Median)
Bright Light Therapy	18
Sham Light	18.5

Monday, Wednesday, and Friday assessments will begin after beginning light therapy and include the Delirium Rating Scale-Revised-98 (DRS-98)and Memorial Delirium Assessment Scale (MDAS) (NCT01700816)
Timeframe: From hospital admission until the date of first documented delirium, assessed up to 28 days post-transplant

Platelet Count

Intervention	Participants (Count of Participants)
Bright Light Therapy	1
Sham Light	0

Red Blood Cells (RBC)

Intervention	thousand cells/uL (Median)
Bright Light Therapy	39
Sham Light	33.5

Severity of Delirium Episodes: Memorial Delirium Assessment Scale (MDAS)

Intervention	M/uL (Median)
Bright Light Therapy	3.21
Sham Light	2.93

"Monday, Wednesday, and Friday assessments of the Memorial Delirium Assessment Scale (MDAS); Patients will receive assessments after beginning light therapy until day 28 post-transplant or discharge, whichever comes first.~10 item scale Items are rated on a four-point scale from 0 (none) to 3 (severe) depending on the level of impairment, rendering a maximum possible score of 30.~A score of 13 has been recommended as a cut-off for establishing the diagnosis of delirium" (NCT01700816)
Timeframe: From first documented episode of delirium until discharge from the hospital, assessed up to 28 days post-transplant

White Blood Cells (WBC)

Intervention	units on a scale (Number)
Bright Light Therapy	18

Serum Creatinine and Blood Urea Nitrogen (BUN)

Intervention	K/uL (Median)
Bright Light Therapy	2.30
Sham Light	4.75

Sodium (Na), Potassium (K), Chloride (Cl), and Carbon Dioxide (CO2)

Intervention	mg/dl (Median)
	Serum Creatinine	Blood Urea Nitrogen (BUN)
Bright Light Therapy	0.66	9
Sham Light	0.75	8.5

Lab values at latest available follow-up date per participant. These tests are performed as part of routine clinical care on patients undergoing HSCT (Hematopoietic Stem Cell Transplantation). (NCT01700816)
Timeframe: From admission to hospital to discharge, an expected average of 28 days post-transplant

Intervention	mmol/L (Median)
	Sodium (Na)	Potassium (K)	Chloride (Cl)	Carbon Dioxide (CO2)
Bright Light Therapy	139	3.6	105	24.9
Sham Light	138.0	3.80	103.0	25.10

Article	Year
Issues facing home-based medical support services. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2010, Volume: 10, Issue:2 Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Caregivers; Delirium; Dementia; Diagnosis, Differenti	2010
[Delirium]. Psychologie & neuropsychiatrie du vieillissement, 2007, Volume: 5, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Confusion; Delirium;	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Interventions for preventing delirium in hospitalised patients. The Cochrane database of systematic reviews, 2007, Apr-18, Issue:2 Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Ha	2007
Cholinesterase inhibitors for delirium. The Cochrane database of systematic reviews, 2008, Jan-23, Issue:1 Topics: Cholinesterase Inhibitors; Delirium; Donepezil; Humans; Indans; Piperidines	2008

Article	Year
Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. Journal of the American Geriatrics Society, 2011, Volume: 59 Suppl 2 Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delirium; Donepezil; Double-Blind Method; Female	2011
Donepezil in the prevention and treatment of post-surgical delirium. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2005, Volume: 13, Issue:12 Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delirium; Donepezil; Double-Blind Method; Female	2005
A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. International journal of geriatric psychiatry, 2007, Volume: 22, Issue:4 Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Delirium; Donepezil; Double-Blind Method; E	2007

Article	Year
Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023, Volume: 19, Issue:5 Topics: Cholinergic Agents; Critical Illness; Delirium; Dementia; Donepezil; Humans	2023
Clinical Pearls in Geriatrics. Disease-a-month : DM, 2017, Volume: 63, Issue:6 Topics: Acetaminophen; Aged; Aged, 80 and over; Automobile Driving; Cognition Disorders; Cognitive Dysfuncti	2017
Could delirium and anti-dementia drugs effect the treatment of agitated nursing home residents with Alzheimer dementia? Journal of the American Medical Directors Association, 2018, Volume: 19, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Delirium; Don	2018
Prolonged Post-Electroconvulsive Therapy Delirium Controlled With Donepezil. The journal of ECT, 2019, Volume: 35, Issue:3 Topics: Bipolar Disorder; Chronic Disease; Delirium; Donepezil; Electroconvulsive Therapy; Female; Humans; M	2019
Challenges in the management of delirium: a case of augmentation with donepezil following inadequate response and adverse effects with risperidone. Psychiatria Danubina, 2015, Volume: 27, Issue:1 Topics: Anticholinergic Syndrome; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Burns; Cholinestera	2015
Withdrawal syndrome after donepezil cessation in a patient with dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012, Volume: 33, Issue:6 Topics: Alzheimer Disease; Cholinesterase Inhibitors; Delirium; Dementia; Donepezil; Female; Humans; Indans;	2012
Delayed onset and prolonged interictal delirium following electroconvulsive therapy. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2012, Volume: 12, Issue:3 Topics: Cholinesterase Inhibitors; Delirium; Depressive Disorder; Donepezil; Electroconvulsive Therapy; Foll	2012
Donepezil for anticholinergic drug intoxication: a case report. Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:5 Topics: Amitriptyline; Cholinergic Antagonists; Delirium; Donepezil; Drug Overdose; Humans; Indans; Male; Mi	2003
Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil. Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:7 Topics: Aged; Basal Ganglia Cerebrovascular Disease; Basal Nucleus of Meynert; Craniopharyngioma; Delirium;	2004
Treatment of post-electroconvulsive therapy delirium and agitation with donepezil. The journal of ECT, 2007, Volume: 23, Issue:1 Topics: Aged; Cholinesterase Inhibitors; Delirium; Depressive Disorder, Major; Donepezil; Electroconvulsive	2007
Dementia with Lewy bodies: response of delirium-like features to donepezil. Neurology, 1998, Volume: 51, Issue:5 Topics: Aged; Brain; Delirium; Dementia; Donepezil; Humans; Indans; Lewy Bodies; Magnetic Resonance Imaging;	1998
Donepezil improves symptoms of delirium in dementia: implications for future research. Journal of geriatric psychiatry and neurology, 1998,Fall, Volume: 11, Issue:3 Topics: Aged; Alcohol Withdrawal Delirium; Cholinesterase Inhibitors; Cognition Disorders; Delirium; Dementi	1998
Donepezil for postoperative delirium associated with Alzheimer's disease. Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:3 Topics: Aged; Alzheimer Disease; Delirium; Donepezil; Geriatric Assessment; Humans; Indans; Male; Nootropic	1999
Delirium caused by donepezil: a case study. The Journal of clinical psychiatry, 2002, Volume: 63, Issue:3 Topics: Aged; Alzheimer Disease; Atrophy; Cerebral Cortex; Delirium; Donepezil; Humans; Indans; Male; Nootro	2002

donepezil and Delirium of Mixed Origin